Advances in canine distemper virus pathogenesis research: a wildlife perspective Free

Abstract

Canine distemper virus (CDV) has emerged as a significant disease of wildlife, which is highly contagious and readily transmitted between susceptible hosts. Initially described as an infectious disease of domestic dogs, it is now recognized as a global multi-host pathogen, infecting and causing mass mortalities in a wide range of carnivore species. The last decade has seen the effect of numerous CDV outbreaks in various wildlife populations. Prevention of CDV requires a clear understanding of the potential hosts in danger of infection as well as the dynamic pathways CDV uses to gain entry to its host cells and its ability to initiate viral shedding and disease transmission. We review recent research conducted on CDV infections in wildlife, including the latest findings on the causes of host specificity and cellular receptors involved in distemper pathogenesis.

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2017-03-01
2024-03-28
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References

  1. Goller KV, Fyumagwa RD, Nikolin V, East ML, Kilewo M et al. Fatal canine distemper infection in a pack of African wild dogs in the Serengeti ecosystem, Tanzania. Vet Microbiol 2010; 146:245–252 [View Article][PubMed]
    [Google Scholar]
  2. Smith KF, Sax DF, Lafferty KD. Evidence for the role of infectious disease in species extinction and endangerment. Conserv Biol 2006; 20:1349–1357 [View Article][PubMed]
    [Google Scholar]
  3. Daszak P, Cunningham AA, Hyatt AD. Anthropogenic environmental change and the emergence of infectious diseases in wildlife. Acta Trop 2001; 78:103–116 [View Article][PubMed]
    [Google Scholar]
  4. Munson L, Karesh W. Disease monitoring for the conservation of terrestrial animals. In Conservation Medicine, Ecological Health in Practice Oxford, UK: Oxford University Press; 200295–102
    [Google Scholar]
  5. Wobeser GA. Disease in Wild Animals: Investigation and Management Berlin: Springer-Verlag; 2007 [Crossref]
    [Google Scholar]
  6. Packer C, Altizer S, Appel M, Brown E, Martenson J et al. Viruses of the Serengeti: patterns of infection and mortality in African lions. J Anim Ecol 1999; 68:1161–1178 [View Article]
    [Google Scholar]
  7. Young TP. Natural die-offs of large mammals: implications for conservation. Conserv Biol 1994; 8:410–418 [View Article]
    [Google Scholar]
  8. Grenfell BT, Gulland FM. Introduction: ecological impact of parasitism on wildlife host populations. Parasitology 1995; 111:S3 [View Article][PubMed]
    [Google Scholar]
  9. Mccallum H, Dobson A. Detecting disease and parasite threats to endangered species and ecosystems. Trends Ecol Evol 1995; 10:190–194 [View Article][PubMed]
    [Google Scholar]
  10. Beineke A, Baumgärtner W, Wohlsein P. Cross-species transmission of canine distemper virus – an update. One Health 2015; 1:49–59 [View Article]
    [Google Scholar]
  11. Deem SL, Spelman LH, Yates RA, Montali RJ. Canine distemper in terrestrial carnivores: a review. J Zoo Wildl Med 2000; 31:441–451 [View Article][PubMed]
    [Google Scholar]
  12. Ripple WJ, Estes JA, Beschta RL, Wilmers CC, Ritchie EG et al. Status and ecological effects of the world's largest carnivores. Science 2014; 343:1241484 [View Article][PubMed]
    [Google Scholar]
  13. Viana M, Cleaveland S, Matthiopoulos J, Halliday J, Packer C et al. Dynamics of a morbillivirus at the domestic–wildlife interface: canine distemper virus in domestic dogs and lions. Proc Natl Acad Sci USA 2015; 112:1464–1469 [View Article][PubMed]
    [Google Scholar]
  14. Woodroffe R. Managing disease threats to wild mammals. Anim Conserv 1999; 2:185–193 [View Article]
    [Google Scholar]
  15. Barrett T. Morbillivirus infections, with special emphasis on morbilliviruses of carnivores. Vet Microbiol 1999; 69:3–13 [View Article][PubMed]
    [Google Scholar]
  16. Lamb RA, Kolakofsky D. Paramyxovirus: the virus and their replication. In Fields BN, Knipe DM. (editors) Fields Virology, 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 20011305–1340
    [Google Scholar]
  17. Osterhaus AD, Groen J, Spijkers HE, Broeders HW, Uytdehaag FG et al. Mass mortality in seals caused by a newly discovered virus-like morbillivirus. Vet Microbiol 1990; 23:343–350[PubMed] [Crossref]
    [Google Scholar]
  18. Pringle CR. Virus Taxonomy at the XIth International Congress of Virology, Sydney, Australia, 1999. Arch Virol 1999; 144:2065–2070 [View Article]
    [Google Scholar]
  19. Curran MD, O'Loan D, Kennedy S, Rima BK. Molecular characterization of phocine distemper virus: gene order and sequence of the gene encoding the attachment (H) protein. J Gen Virol 1992; 73:1189–1194 [View Article][PubMed]
    [Google Scholar]
  20. Diallo A. Morbillivirus group: genome organisation and proteins. Vet Microbiol 1990; 23:155–163 [View Article][PubMed]
    [Google Scholar]
  21. Martella V, Cirone F, Elia G, Lorusso E, Decaro N et al. Heterogeneity within the hemagglutinin genes of canine distemper virus (CDV) strains detected in Italy. Vet Microbiol 2006; 116:301–309 [View Article][PubMed]
    [Google Scholar]
  22. Barrett T, Shrimpton SB, Russell SE. Nucleotide sequence of the entire protein coding region of canine distemper virus polymerase-associated (P) protein mRNA. Virus Res 1985; 3:367–372 [View Article][PubMed]
    [Google Scholar]
  23. Bellini WJ, Englund G, Richardson CD, Rozenblatt S, Lazzarini RA. Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences, and deduced amino acid sequences. J Virol 1986; 58:408–416[PubMed]
    [Google Scholar]
  24. Lamb RA, Parks G. Paramyxoviridae: the viruses and their replication. In Knipe DM, Howley PM. (editors) Fields Virology, 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins, PA; 2013957–995
    [Google Scholar]
  25. Sidhu MS, Husar W, Cook SD, Dowling PC, Udem SA. Canine distemper terminal and intergenic non-protein coding nucleotide sequences: completion of the entire CDV genome sequence. Virology 1993; 193:66–72 [View Article][PubMed]
    [Google Scholar]
  26. Marcacci M, Ancora M, Mangone I, Teodori L, di Sabatino D et al. Whole genome sequence analysis of the arctic-lineage strain responsible for distemper in Italian wolves and dogs through a fast and robust next generation sequencing protocol. J Virol Methods 2014; 202:64–68 [View Article][PubMed]
    [Google Scholar]
  27. Harder TC, Osterhaus AD. Canine distemper virus – a morbillivirus in search of new hosts?. Trends Microbiol 1997; 5:120–124 [View Article][PubMed]
    [Google Scholar]
  28. Ke GM, Ho CH, Chiang MJ, Sanno-Duanda B, Chung CS et al. Phylodynamic analysis of the canine distemper virus hemagglutinin gene. BMC Vet Res 2015; 11:164 [View Article][PubMed]
    [Google Scholar]
  29. Martinez-Gutierrez M, Ruiz-Saenz J. Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Vet Res 2016; 12:78 [View Article][PubMed]
    [Google Scholar]
  30. Panzera Y, Sarute N, Iraola G, Hernández M, Pérez R. Molecular phylogeography of canine distemper virus: geographic origin and global spreading. Mol Phylogenet Evol 2015; 92:147–154 [View Article][PubMed]
    [Google Scholar]
  31. Budaszewski RF, Pinto LD, Weber MN, Caldart ET, Alves CD et al. Genotyping of canine distemper virus strains circulating in Brazil from 2008 to 2012. Virus Res 2014; 180:76–83 [View Article][PubMed]
    [Google Scholar]
  32. Haas L, Martens W, Greiser-Wilke I, Mamaev L, Butina T et al. Analysis of the haemagglutinin gene of current wild-type canine distemper virus isolates from Germany. Virus Res 1997; 48:165–171 [View Article][PubMed]
    [Google Scholar]
  33. Hashimoto M, Une Y, Mochizuki M. Hemagglutinin genotype profiles of canine distemper virus from domestic dogs in Japan. Arch Virol 2001; 146:149–155 [View Article][PubMed]
    [Google Scholar]
  34. Panzera Y, Sarute N, Iraola G, Hernández M, Pérez R. Molecular phylogeography of canine distemper virus: geographic origin and global spreading. Mol Phylogenet Evol 2015; 92:147–154 [View Article][PubMed]
    [Google Scholar]
  35. Mamaev LV, Denikina NN, Belikov SI, Volchkov VE, Visser IK et al. Characterisation of morbilliviruses isolated from Lake Baikal seals (Phoca sibirica). Vet Microbiol 1995; 44:251–259 [View Article][PubMed]
    [Google Scholar]
  36. Kennedy S, Kuiken T, Jepson PD, Deaville R, Forsyth M et al. Mass die-Off of Caspian seals caused by canine distemper virus. Emerg Infect Dis 2000; 6:637–639 [View Article][PubMed]
    [Google Scholar]
  37. Forsyth MA, Kennedy S, Wilson S, Eybatov T, Barrett T. Canine distemper virus in a Caspian seal. Vet Rec 1998; 143:662–664[PubMed]
    [Google Scholar]
  38. Qiu W, Zheng Y, Zhang S, Fan Q, Liu H et al. Canine distemper outbreak in rhesus monkeys, China. Emerg Infect Dis 2011; 17:1541–1543 [View Article][PubMed]
    [Google Scholar]
  39. Sun Z, Li A, Ye H, Shi Y, Hu Z et al. Natural infection with canine distemper virus in hand-feeding rhesus monkeys in China. Vet Microbiol 2010; 141:374–378 [View Article][PubMed]
    [Google Scholar]
  40. Cosby SL. Morbillivirus cross-species infection: is there a risk for humans?. Future Virol 2012; 7:1103–1113 [View Article]
    [Google Scholar]
  41. Appel MJ, Yates RA, Foley GL, Bernstein JJ, Santinelli S et al. Canine distemper epizootic in lions, tigers, and leopards in North America. J Vet Diagn Invest 1994; 6:277–288 [View Article][PubMed]
    [Google Scholar]
  42. Guiserix M, Bahi-Jaber N, Fouchet D, Sauvage F, Pontier D. The canine distemper epidemic in Serengeti: are lions victims of a new highly virulent canine distemper virus strain, or is pathogen circulation stochasticity to blame?. J R Soc Interface 2007; 4:1127–1134 [View Article][PubMed]
    [Google Scholar]
  43. Harder TC, Kenter M, Vos H, Siebelink K, Huisman W et al. Canine distemper virus from diseased large felids: biological properties and phylogenetic relationships. J Gen Virol 1996; 77:397–405 [View Article][PubMed]
    [Google Scholar]
  44. Roelke-Parker ME, Munson L, Packer C, Kock R, Cleaveland S et al. A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature 1996; 379:441–445 [View Article][PubMed]
    [Google Scholar]
  45. Seimon TA, Miquelle DG, Chang TY. Canine distemper virus: an emerging disease in wild endangered. MBio 2013; 4:e0041000413 [Crossref]
    [Google Scholar]
  46. Appel M, Sheffy BE, Percy DH, Gaskin JM. Canine distemper virus in domestic cats and pigs. Am J Vet Res 1974; 35:803–806
    [Google Scholar]
  47. Ikeda Y, Nakamura K, Miyazawa T, Chen M, Kuo T et al. Seroprevalence of canine distemper virus in cats. Clin Diagn Lab Immunol 2001; 8:641–644
    [Google Scholar]
  48. Munson L, Marker L, Dubovi E, Spencer JA, Evermann JF et al. Serosurvey of viral infections in free-ranging Namibian cheetahs (Acinonyx jubatus). J Wildl Dis 2004; 40:23–31 [View Article][PubMed]
    [Google Scholar]
  49. Thalwitzer S, Wachter B, Robert N, Wibbelt G, Müller T et al. Seroprevalences to viral pathogens in free-ranging and captive cheetahs (Acinonyx jubatus) on Namibian farmland. Clin Vaccine Immunol 2010; 17:232–238 [View Article][PubMed]
    [Google Scholar]
  50. Gordon CH, Banyard AC, Hussein A, Laurenson MK, Malcolm JR et al. Canine distemper in endangered Ethiopian wolves. Emerg Infect Dis 2015; 21:824–832 [View Article][PubMed]
    [Google Scholar]
  51. Feng N, Yu Y, Wang T, Wilker P, Wang J et al. Fatal canine distemper virus infection of giant pandas in China. Sci Rep 2016; 6:27518 [View Article]
    [Google Scholar]
  52. Hvistendahl M. Captive pandas succumb to killer virus. Science 2015; 347:700–701 [View Article]
    [Google Scholar]
  53. Greene CE, Appel MJG. Canine distemper. In: Greene C. (editor) Infectious Diseases in Dog and Cat Philadelphia, PA: W B Saunders; 1990 pp. 226–241
    [Google Scholar]
  54. Williams ES. Canine distemper. In: Williams E, Barker IK. (editors) Infectious Diseases of Wild Mammals Ames, IA: Lowa State University Press; 2001 pp. 50–59 [Crossref]
    [Google Scholar]
  55. Appel MJG. Canine distemper virus. In: Appel MJG. (editor) Virus Infections of Carnivores New York, NY: Elsevier Science Publishers; 1987133–159
    [Google Scholar]
  56. Kingsbury DW, Bratt MA, Choppin PW, Hanson RP, Hosaka Y et al. Paramyxovirdae. Intervirology 1978; 10:137–152 [View Article][PubMed]
    [Google Scholar]
  57. Greene CE, Appel MJG. Canine distemper. In: Greene C. (editor) Clinical Microbiology Infections of Dog and Cat Philadelphia, PA: W B Saunders; 1984 pp 386–405
    [Google Scholar]
  58. Alexander KA, Mcnutt JW, Briggs MB, Standers PE, Funston P et al. Multi-host pathogens and carnivore management in southern Africa. Comp Immunol Microbiol Infect Dis 2010; 33:249–265 [View Article][PubMed]
    [Google Scholar]
  59. Berentsen AR, Dunbar MR, Becker MS, M'Soka J, Droge E et al. Rabies, canine distemper, and canine parvovirus exposure in large carnivore communities from two Zambian ecosystems. Vector Borne Zoonotic Dis 2013; 13:643–649 [View Article][PubMed]
    [Google Scholar]
  60. Cleaveland S, Appel MG, Chalmers WS, Chillingworth C, Kaare M et al. Serological and demographic evidence for domestic dogs as a source of canine distemper virus infection for Serengeti wildlife. Vet Microbiol 2000; 72:217–227 [View Article][PubMed]
    [Google Scholar]
  61. Flacke G, Becker P, Cooper D, Szykman Gunther M, Robertson I et al. An infectious disease and mortality survey in a population of free-ranging African wild dogs and sympatric domestic dogs. Int J Biodivers 2013; 2013:1–9 [View Article]
    [Google Scholar]
  62. Laurenson K, van Heerden J, Stander P, van Vuuren MJ. Seroepidemiological survey of sympatric domestic and wild dogs (Lycaon pictus) in Tsumkwe district, north-eastern Namibia. Onderstepoort J Vet Res 1997; 64:313–316[PubMed]
    [Google Scholar]
  63. Butler JR, du Toit J, Bingham J. Free-ranging domestic dogs (Canis familiaris) as predators and prey in rural Zimbabwe: threats of competition and disease to large wild carnivores. Biol Conserv 2004; 115:369–378 [View Article]
    [Google Scholar]
  64. Appel MJ. Distemper pathogenesis in dogs. J Am Vet Med Assoc 1970; 156:1681–1684[PubMed]
    [Google Scholar]
  65. Schobesberger M, Summerfield A, Doherr MG, Zurbriggen A, Griot C. Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis. Vet Immunol Immunopathol 2005; 104:33–44 [View Article][PubMed]
    [Google Scholar]
  66. Bittegeko SB, Arnbjerg J, Nkya R, Tevik A. Multiple dental developmental abnormalities following canine distemper infection. J Am Anim Hosp Assoc 1995; 31:42–45 [View Article][PubMed]
    [Google Scholar]
  67. Dubielzig RR, Higgins RJ, Krakowka S. Lesions of the enamel organ of developing dog teeth following experimental inoculation of gnotobiotic puppies with canine distemper virus. Vet Pathol 1981; 18:684–689[PubMed] [Crossref]
    [Google Scholar]
  68. Baumgärtner W. [Viral Infectious Diseases in Puppies and Young Dogs, with Special Consideration of Distemper Virus Infections]. Prakt Tierarzt 1993; 74:26–32 (in German)
    [Google Scholar]
  69. Krakowka S, Axthelm M, Johnson GC. Canine distemper virus. In Olsen RG, Krakowka S, Blakeslee J. (editors) Comparative Pathobiology of Viral Diseases vol. 2 Boca Raton, FL: CRC Press; 1985137–164
    [Google Scholar]
  70. Appel MJ, Shek WR, Summers BA. Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus. Infect Immun 1982; 37:592–600[PubMed]
    [Google Scholar]
  71. Winters KA, Mathes LE, Krakowka S, Olsen RG. Immunoglobulin class response to canine distemper virus in gnotobiotic dogs. Vet Immunol Immunopathol 1983; 5:209–215 [View Article][PubMed]
    [Google Scholar]
  72. Appel MJ, Reggiardo C, Summers BA, Pearce-Kelling S, Maré CJ et al. Canine distemper virus infection and encephalitis in javelinas (collared peccaries). Arch Virol 1991; 119:147–152 [View Article][PubMed]
    [Google Scholar]
  73. Appel MJ, Mendelson SG, Hall WW. Macrophage Fc receptors control infectivity and neutralization of canine distemper virus–antibody complexes. J Virol 1984; 51:643–649[PubMed]
    [Google Scholar]
  74. Krakowka S, Cockerell G, Koestner A. Effects of canine distemper virus infection on lymphoid function in vitro and in vivo . Infect Immun 1975; 11:1069–1078[PubMed]
    [Google Scholar]
  75. Leisewitz AL, Carter A, van Vuuren M, van Blerk L. Canine distemper infections, with special reference to South Africa, with a review of the literature. J S Afr Vet Assoc 2001; 72:127–136 [View Article][PubMed]
    [Google Scholar]
  76. Hueffer K, Parker JS, Weichert WS, Geisel RE, Sgro JY et al. The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor. J Virol 2003; 77:1718–1726 [View Article][PubMed]
    [Google Scholar]
  77. Kaelber JT, Demogines A, Harbison CE, Allison AB, Goodman LB et al. Evolutionary reconstructions of the transferrin receptor of caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs. PLoS Pathog 2012; 8:e1002666-10 [View Article]
    [Google Scholar]
  78. Qu XX, Hao P, Song XJ, Jiang SM, Liu YX et al. Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy. J Biol Chem 2005; 280:29588–29595 [View Article][PubMed]
    [Google Scholar]
  79. Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med 2006; 84:712–725 [View Article][PubMed]
    [Google Scholar]
  80. Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM et al. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 20111–5 [View Article]
    [Google Scholar]
  81. Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H et al. Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence. J Virol 2012; 86:10207–10210 [View Article][PubMed]
    [Google Scholar]
  82. Tatsuo H, Ono N, Yanagi Y. Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. J Virol 2001; 75:5842–5850 [View Article][PubMed]
    [Google Scholar]
  83. Ono N, Tatsuo H, Tanaka K, Minagawa H, Yanagi Y. V domain of human SLAM (CDw150) is essential for its function as a measles virus receptor. J Virol 2001; 75:1594–1600 [View Article][PubMed]
    [Google Scholar]
  84. Seki F, Ono N, Yamaguchi R, Yanagi Y. Efficient isolation of wild strains of canine distemper virus in Vero cells expressing canine SLAM (CD150) and their adaptability to marmoset B95a cells. J Virol 2003; 77:9943–9950 [View Article][PubMed]
    [Google Scholar]
  85. Noyce RS, Delpeut S, Richardson CD. Dog nectin-4 is an epithelial cell receptor for canine distemper virus that facilitates virus entry and syncytia formation. Virology 2013; 436:210–220 [View Article][PubMed]
    [Google Scholar]
  86. Reymond N, Fabre S, Lecocq E, Adelaïde J, Dubreuil P et al. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem 2001; 276:43205–43215 [View Article][PubMed]
    [Google Scholar]
  87. Bolt G, Jensen TD, Gottschalck E, Arctander P, Appel MJ et al. Genetic diversity of the attachment (H) protein gene of current field isolates of canine distemper virus. J Gen Virol 1997; 78:367–372 [View Article][PubMed]
    [Google Scholar]
  88. Mccarthy AJ, Shaw MA, Goodman SJ. Pathogen evolution and disease emergence in carnivores. Proc Biol Sci 2007; 274:3165–3174 [View Article][PubMed]
    [Google Scholar]
  89. Nikolin VM, Osterrieder K, von Messling V, Hofer H, Anderson D et al. Antagonistic pleiotropy and fitness trade-offs reveal specialist and generalist traits in strains of canine distemper virus. PLoS One 2012; 7:e50955 [View Article][PubMed]
    [Google Scholar]
  90. Ohishi K, Suzuki R, Maeda T, Tsuda M, Abe E et al. Recent host range expansion of canine distemper virus and variation in its receptor, the signaling lymphocyte activation molecule, in carnivores. J Wildl Dis 2014; 50:596–606 [View Article][PubMed]
    [Google Scholar]
  91. von Messling V, Svitek N, Cattaneo R. Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus. J Virol 2006; 80:6084–6092 [View Article][PubMed]
    [Google Scholar]
  92. Zipperle L, Langedijk JP, Orvell C, Vandevelde M, Zurbriggen A et al. Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity. J Virol 2010; 84:9618–9624 [View Article][PubMed]
    [Google Scholar]
  93. Nikolin VM, Wibbelt G, Michler FU, Wolf P, East ML. Susceptibility of carnivore hosts to strains of canine distemper virus from distinct genetic lineages. Vet Microbiol 2012; 156:45–53 [View Article][PubMed]
    [Google Scholar]
  94. Ludlow M, Nguyen DT, Silin D, Lyubomska O, de Vries RD et al. Recombinant canine distemper virus strain Snyder Hill expressing green or red fluorescent proteins causes meningoencephalitis in the ferret. J Virol 2012; 86:7508–7519 [View Article][PubMed]
    [Google Scholar]
  95. von Messling V, Milosevic D, Cattaneo R. Tropism illuminated: lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system. Proc Natl Acad Sci USA 2004; 101:14216–14221 [View Article][PubMed]
    [Google Scholar]
  96. Delpeut S, Noyce RS, Richardson CD. The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread. Virology 2014; 454–455:109–117 [View Article][PubMed]
    [Google Scholar]
  97. Iwatsuki K, Okita M, Ochikubo F, Gemma T, Shin YS et al. Immunohistochemical analysis of the lymphoid organs of dogs naturally infected with canine distemper virus. J Comp Pathol 1995; 113:185–190 [View Article][PubMed]
    [Google Scholar]
  98. Beineke A, Puff C, Seehusen F, Baumgärtner W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol 2009; 127:1–18 [View Article][PubMed]
    [Google Scholar]
  99. Ludlow M, Rennick LJ, Nambulli S, de Swart RL, Duprex WP. Using the ferret model to study morbillivirus entry, spread, transmission and cross-species infection. Curr Opin Virol 2014; 4:15–23 [View Article][PubMed]
    [Google Scholar]
  100. Delpeut S, Noyce RS, Richardson CD. The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses. Viruses 2014; 6:2268–2286 [View Article][PubMed]
    [Google Scholar]
  101. Martella V, Elia G, Buonavoglia C. Canine distemper virus. Vet Clin North Am Small Anim Pract 2008; 38:787–797 [View Article][PubMed]
    [Google Scholar]
  102. Soma T, Uemura T, Nakamoto Y, Ozawa T, Bandai T et al. Canine distemper virus antibody test alone increases misdiagnosis of distemper encephalitis. Vet Rec 2013; 173:477 [View Article][PubMed]
    [Google Scholar]
  103. Castilho JG, Brandão PE, Carnieli P, Oliveira RN, Macedo CI et al. Molecular analysis of the N gene of canine distemper virus in dogs in Brazil. Arq Bras Med Vet e Zootec 2007; 59:654–659 [View Article]
    [Google Scholar]
  104. Frisk AL, König M, Moritz A, Baumgärtner W. Detection of canine distemper virus nucleoprotein RNA by reverse transcription-PCR using serum, whole blood, and cerebrospinal fluid from dogs with distemper. J Clin Microbiol 1999; 37:3634–3643[PubMed]
    [Google Scholar]
  105. Saito TB, Alfieri AA, Wosiacki SR, Negrão FJ, Morais HS et al. Detection of canine distemper virus by reverse transcriptase-polymerase chain reaction in the urine of dogs with clinical signs of distemper encephalitis. Res Vet Sci 2006; 80:116–119 [View Article][PubMed]
    [Google Scholar]
  106. Yi L, Cheng S, Xu H, Wang J, Cheng Y et al. Development of a combined canine distemper virus specific RT-PCR protocol for the differentiation of infected and vaccinated animals (DIVA) and genetic characterization of the hemagglutinin gene of seven Chinese strains demonstrated in dogs. J Virol Methods 2012; 179:281–287 [View Article][PubMed]
    [Google Scholar]
  107. Elia G, Decaro N, Martella V, Cirone F, Lucente MS et al. Detection of canine distemper virus in dogs by real-time RT-PCR. J Virol Methods 2006; 136:171–176 [View Article][PubMed]
    [Google Scholar]
  108. Scagliarini A, dal Pozzo F, Gallina L, Vaccari F, Morganti L. TaqMan based real time PCR for the quantification of canine distemper virus. Vet Res Commun 2007; 31:261–263 [View Article][PubMed]
    [Google Scholar]
  109. Wilkes RP, Sanchez E, Riley MC, Kennedy MA. Real-time reverse transcription polymerase chain reaction method for detection of canine distemper virus modified live vaccine shedding for differentiation from infection with wild-type strains. J Vet Diag Invest 2014; 26:27–34 [View Article]
    [Google Scholar]
  110. Shin YJ, Cho KO, Cho HS, Kang SK, Kim HJ et al. Comparison of one-step RT-PCR and a nested PCR for the detection of canine distemper virus in clinical samples. Aust Vet J 2004; 82:83–86 [View Article][PubMed]
    [Google Scholar]
  111. Alcalde R, Kogika MM, Fortunato VAB, Lopes LR, Paiva PB et al. [Canine distemper virus: detection of viral RNA by nested RT-PCR in dogs with clinical diagnosis]. Braz J Vet Res Anim Sci 2013; 50:74–76 (in Portuguese) [View Article]
    [Google Scholar]
  112. Fischer CD, Ikuta N, Canal CW, Makiejczuk A, Allgayer MC et al. Detection and differentiation of field and vaccine strains of canine distemper virus using reverse transcription followed by nested real time PCR (RT-nqPCR) and RFLP analysis. J Virol Methods 2013; 194:39–45 [View Article][PubMed]
    [Google Scholar]
  113. Blixenkrone-Moller M, Pedersen IR, Appel MJ, Griot C. Detection of IgM antibodies against canine distemper virus in dog and mink sera employing enzyme-linked immunosorbent assay (ELISA). J Vet diagnostic Investig 1991; 3:3–9 [View Article]
    [Google Scholar]
  114. Haas L, Liermann H, Harder TC, Barrett T, Löchelt M et al. Analysis of the H gene, the central untranslated region and the proximal coding part of the F gene of wild-type and vaccine canine distemper viruses. Vet Microbiol 1999; 69:15–18 [View Article][PubMed]
    [Google Scholar]
  115. Appel M, Robson DS. A microneutralization test for canine distemper virus. Am J Vet Res 1973; 34:1459–1463[PubMed]
    [Google Scholar]
  116. Prager KC, Mazet JA, Dubovi EJ, Frank LG, Munson L et al. Rabies virus and canine distemper virus in wild and domestic carnivores in northern Kenya: are domestic dogs the reservoir?. Ecohealth 2012; 9:483–498 [View Article][PubMed]
    [Google Scholar]
  117. Kapil S, Yeary TJ. Canine distemper spillover in domestic dogs from urban wildlife. Vet Clin Small Anim 2011; 41:1069–1086 [View Article]
    [Google Scholar]
  118. Kim YH, Cho KW, Youn HY, Yoo HS, Han HR. Detection of canine distemper virus (CDV) through one step RT-PCR combined with nested PCR. J Vet Sci (Suwon-si, Korea) 2001; 2:59–63
    [Google Scholar]
  119. Shin Y, Mori T, Okita M, Gemma T, Kai C et al. Detection of canine distemper virus nucleocapsid protein gene in canine peripheral blood mononuclear cells by RT-PCR. J Vet Med Sci 1995; 57:439–445 [View Article][PubMed]
    [Google Scholar]
  120. Appel MJG, Pearce-Kelling S, Summers BA. Dog lymphocyte cultures facilitate the isolation and growth of virulent canine distemper virus. J Vet Diagnostic Investig 1992; 4:258–263 [View Article]
    [Google Scholar]
  121. Whetstone CA, Bunn TO, Gourlay JA. Canine distemper virus titration in ferret peritoneal macrophages. Cornell Vet 1981; 71:144–148[PubMed]
    [Google Scholar]
  122. Woma TY, van Vuuren M. Isolation of canine distemper viruses from domestic dogs in South Africa using Vero.DogSLAM cells and its application to diagnosis. African J Microbiol Res 2009; 3:111–118
    [Google Scholar]
  123. Jóźwik A, Frymus T. Comparison of the immunofluorescence assay with RT-PCR and nested PCR in the diagnosis of canine distemper. Vet Res Commun 2005; 29:347–359 [View Article][PubMed]
    [Google Scholar]
  124. Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T et al. Orally available small-molecule polymerase inhibitor cures a lethal morbillivirus infection. Sci Transl Med 2014; 6:232ra52 [Crossref]
    [Google Scholar]
  125. Trejo-Avila LM, Morales-Martínez ME, Ricque-Marie D, Cruz-Suarez LE, Zapata-Benavides P et al. In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus . Virus Dis 2014; 25:474–480 [View Article]
    [Google Scholar]
  126. Carvalho OV, Botelho CV, Ferreira CG, Ferreira HC, Santos MR et al. In vitro inhibition of canine distemper virus by flavonoids and phenolic acids: implications of structural differences for antiviral design. Res Vet Sci 2013; 95:717–724 [View Article][PubMed]
    [Google Scholar]
  127. Pinheiro AO, Cardoso MT, Vidane AS, Casals JB, Passarelli D et al. Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease. Genet Mol Res 2016; 15:1–14 [Crossref]
    [Google Scholar]
  128. Bogdanchikova N, Muñoz RV, Saquero AH, Jasso AP, Uzcanga GA et al. Silver nanoparticles composition for treatment of distemper in dogs. Int J Nanotechnol 2016; 13:227–237 [View Article]
    [Google Scholar]
  129. Haig DA. Canine distemper-immunization with avianised virus. Onderstepoort J Vet Res 1956; 27:19–53
    [Google Scholar]
  130. Rockborn G. An attenuated strain of canine distemper virus in tissue culture. Nature 1959; 184:822 [View Article][PubMed]
    [Google Scholar]
  131. Hartley WJ. A post-vaccinal inclusion body encephalitis in dogs. Vet Pathol Online 1974; 11:301–312 [Crossref]
    [Google Scholar]
  132. Carpenter JW, Appel MJ, Erickson RC, Novilla MN. Fatal vaccine-induced canine distemper virus infection in black-footed ferrets. J Am Vet Med Assoc 1976; 169:961–964[PubMed]
    [Google Scholar]
  133. Sutherland-Smith MR, Rideout BA, Mikolon AB, Appel MJ, Morris PJ et al. Vaccine-induced canine distemper in European mink, Mustela lutreola . J Zoo Wildl Med 1997; 28:312–318[PubMed]
    [Google Scholar]
  134. Halbrooks RD, Swango LJ, Schnurrenberger PR, Mitchell FE, Hill EP. Response of gray foxes to modified live-virus canine distemper vaccines. J Am Vet Med Assoc 1981; 179:1170–1174[PubMed]
    [Google Scholar]
  135. Thomas-Baker B. Vaccination-induced distemper in maned wolves, vaccination-induced corneal opacity in a maned wolf. Proc Am Assoc Zoo Vet 1985; 53:192–197
    [Google Scholar]
  136. Buczkowski H, Muniraju M, Parida S, Banyard AC. Morbillivirus vaccines: recent successes and future hopes. Vaccine 2014; 32:3155–3161 [View Article][PubMed]
    [Google Scholar]
  137. Paoletti E, Taylor J, Meignier B, Meric C, Tartaglia J. Highly attenuated poxvirus vectors: NYVAC, ALVAC and TROVAC. Dev Biol Stand 1995; 84:159–163[PubMed]
    [Google Scholar]
  138. Taylor J, Pincus S, Tartaglia J, Richardson C, Alkhatib G et al. Vaccinia virus recombinants expressing either the measles virus fusion or hemagglutinin glycoprotein protect dogs against canine distemper virus challenge. J Virol 1991; 65:4263–4274[PubMed]
    [Google Scholar]
  139. Taylor J, Tartaglia J, Rivière M, Duret C, Languet B et al. Applications of canarypox (ALVAC) vectors in human and veterinary vaccination. Dev Biol Stand 1994; 82:131–135[PubMed]
    [Google Scholar]
  140. Wimsatt J, Biggins D, Innes K, Taylor B, Garell D. Evaluation of oral and subcutaneous delivery of an experimental canarypox recombinant canine distemper vaccine in the Siberian polecat (Mustela eversmanni). J Zoo Wildl Med 2003; 34:25–35 [View Article][PubMed]
    [Google Scholar]
  141. Bronson E, Deem SL, Sanchez C, Murray S. Serologic response to a canarypox-vectored canine distemper virus vaccine in the giant panda (Ailuropoda melanoleuca). J Zoo Wildl Med 2007; 38:363–366 [View Article][PubMed]
    [Google Scholar]
  142. Coke RL, Backues KA, Hoover JP, Saliki JT, Ritchey JW et al. Serologic responses after vaccination of fennec foxes (Vulpes zerda) and meerkats (Suricata suricatta) with a live, canarypox-vectored canine distemper virus vaccine. J Zoo Wildl Med 2005; 36:326–330 [View Article][PubMed]
    [Google Scholar]
  143. Stephensen CB, Welter J, Thaker SR, Taylor J, Tartaglia J et al. Canine distemper virus (CDV) infection of ferrets as a model for testing Morbillivirus vaccine strategies: NYVAC- and ALVAC-based CDV recombinants protect against symptomatic infection. J Virol 1997; 71:1506–1513[PubMed]
    [Google Scholar]
  144. Sadler RA, Ramsay E, Mcaloose D, Rush R, Wilkes RP. Evaluation of two canine distemper virus vaccines in captive tigers (Panthera tigris). J Zoo Wildl Med 2016; 47:558–563 [View Article][PubMed]
    [Google Scholar]
  145. Rikula U, Nuotio L, Sihvonen L. Vaccine coverage, herd immunity and occurrence of canine distemper from 1990–1996 in Finland. Vaccine 2007; 25:7994–7998 [View Article][PubMed]
    [Google Scholar]
  146. Cleaveland S, Kaare M, Knobel D, Laurenson MK. Canine vaccination – providing broader benefits for disease control. Vet Microbiol 2006; 117:43–50 [View Article][PubMed]
    [Google Scholar]
  147. Montali RJ, Bartz CR, Teare JA, Allen JT, Appel MJ et al. Clinical trials with canine distemper vaccines in exotic carnivores. J Am Vet Med Assoc 1983; 183:1163–1167[PubMed]
    [Google Scholar]
  148. Sato H, Yoneda M, Honda T, Kai C. Morbillivirus receptors and tropism: multiple pathways for infection. Front Microbiol 2012; 3: [View Article]
    [Google Scholar]
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