@article{mbs:/content/journal/jgv/10.1099/jgv.0.000582, author = "Jin, Miao and Zhou, Yong-kang and Xie, Hua-ping and Fu, Jian-guang and He, Ya-qing and Zhang, Shuang and Jing, Hong-bo and Kong, Xiang-yu and Sun, Xiao-man and Li, Hui-ying and Zhang, Qing and Li, Kai and Zhang, Ying-jun and Zhou, De-qian and Xing, Wei-jia and Liao, Qiao-hong and Liu, Na and Yu, Hong-jie and Jiang, Xi and Tan, Ming and Duan, Zhao-jun", title = "Characterization of the new GII.17 norovirus variant that emerged recently as the predominant strain in China", journal= "Journal of General Virology", year = "2016", volume = "97", number = "10", pages = "2620-2632", doi = "https://doi.org/10.1099/jgv.0.000582", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000582", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "Noroviruses", keywords = "gastroenteritis epidemics", keywords = "histo-blood group antigens", abstract = "Human noroviruses are the most important viral pathogens causing epidemic acute gastroenteritis, in which the GII.4 viruses have been predominant worldwide for the past decades. During 2014–2015 winter season, a new GII.17 variant emerged as the predominant virus in China surpassing the GII.4 virus in causing significantly increased acute gastroenteritis outbreaks. Genome sequences of the new GII.17 variant was determined and compared with other GII.17 noroviruses, revealing residue substitutions at specific locations, including the histo-blood group antigen-binding site and the putative antigenic epitopes. Further study of GII.17 outbreaks focusing on host susceptibility showed that the new GII.17 variant infected secretor individuals of A, B, O and Lewis types. Accordingly, the P particles of the new GII.17 variant bound secretor saliva samples of A, B, O and Lewis types with significantly higher binding signals than those of the P particles of the previous GII.17 variants. In addition, human sera collected from the outbreaks exhibited stronger blockade against the binding of the new GII.17 P particles to saliva samples than those against the binding between the P particles of previous GII.17 variants and saliva samples. Taken together, our data strongly suggested that the new GII.17 variant gained new histo-blood group antigen-binding ability and antigenic features, which may contribute to its predominance in causing human norovirus epidemics.", }