1887

Abstract

There have been many outbreaks of hydropericardium syndrome (HPS), which is characterized by pericardial effusion and hepatitis, in Chinese chicken farms since June 2015. HPS was mainly found in miscellaneous meat-type chickens, Ma chickens, layer chicks and Three-yellow chickens, while it was occasionally found in white broilers. To determine the specific causative pathogen and pathogenicity of HPS in chickens, we collected 25 suspected cases and performed clinical pathology and aetiology analyses. The results showed that the 25 cases exhibited multifocal hepatitis with intra-nuclear inclusion bodies and 70 nm-latticed viral particles in the cell nuclei. All samples were positive for fowl adenovirus (FAdV), and sequencing results showed that the hexon gene shared the highest nucleotide similarities with the hexon gene of group 1 serotype 4 (FAdV-4). FAdV-4 was highly pathogenic to embryos and specific pathogen-free chickens, causing 100 and 70 % mortality rates, respectively. Thus, FAdV-4 is associated with HPS outbreaks in China.

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2016-10-13
2021-07-28
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References

  1. Adair B. M., Curran W. L., McFerran J. B. 1979; Ultrastructural studies of the replication of fowl adenoviruses in primary cell cultures. Avian Pathol 8:133–144 [View Article][PubMed]
    [Google Scholar]
  2. Anjum A. D., Sabri M. A., Iqbal Z. 1989; Hydropericarditis syndrome in broiler chickens in Pakistan. Vet Rec 124:247–248 [View Article][PubMed]
    [Google Scholar]
  3. Balamurugan V., Kataria J. M. 2004; The hydropericardium syndrome in poultry—a current scenario. Vet Res Commun 28:127–148[PubMed] [CrossRef]
    [Google Scholar]
  4. Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M. 1996; The complete DNA sequence and genomic organization of the avian adenovirus CELO. J Virol 70:2939–2949[PubMed]
    [Google Scholar]
  5. Choi K. S., Kye S. J., Kim J. Y., Jeon W. J., Lee E. K., Park K. Y., Sung H. W. 2012; Epidemiological investigation of outbreaks of fowl adenovirus infection in commercial chickens in Korea. Poult Sci 91:2502–2506 [View Article][PubMed]
    [Google Scholar]
  6. Dahiya S., Srivastava R. N., Hess M., Gulati B. R. 2002; Fowl adenovirus serotype 4 associated with outbreaks of infectious hydropericardium in Haryana, India. Avian Dis 46:230–233 [View Article][PubMed]
    [Google Scholar]
  7. Hess M. 2000; Detection and differentiation of avian adenoviruses: a review. Avian Pathol 29:195–206 [View Article][PubMed]
    [Google Scholar]
  8. Jadhao S. J., Kataria J. M., Verma K. C., Shah R. L. 1997; Serotyping of Indian isolates of fowl adenovirus recovered from inclusion body hepatitis-hydropericardium syndrome (Litchi disease) in chickens. Indian J Comp Microbiol Immunol Infect Dis 18:33–37
    [Google Scholar]
  9. Ji R. L., Liu Y. L., Qin A. J., Ding J. B., Jin W. J., Zhao W. M., Cui Z. Z., Duan S. H., Gao H. P., Han F. W. 2001; Co-infection detection of the chicken infectious anemia virus and reticuloendotheliosis virus in the immunodepression flock. Chin J Vet Drug 35:1–3 (in Chinese)
    [Google Scholar]
  10. Kaján G. L., Kecskeméti S., Harrach B., Benkő M. 2013; Molecular typing of fowl adenoviruses, isolated in Hungary recently, reveals high diversity. Vet Microbiol 167:357–363 [View Article][PubMed]
    [Google Scholar]
  11. Kim J. N., Byun S. H., Kim M. J., Kim J., Sung H. W., Mo I. P. 2008; Outbreaks of hydropericardium syndrome and molecular characterization of Korean fowl adenoviral isolates. Avian Dis 52:526–530 [View Article][PubMed]
    [Google Scholar]
  12. Liu D., Zhang X. B., Yan Z. Q., Chen F., Ji J., Qin J. P., Li H. Y., Lu J. P., Xue Y. et al. 2013; Molecular characterization and phylogenetic analysis of infectious bursal disease viruses isolated from chicken in South China in 2011. Trop Anim Health Prod 45:1107–1112 [View Article][PubMed]
    [Google Scholar]
  13. Liu L. T., Qu Y. J., Wang T. T., Wang G. W., Wang F. K., Liu S. 2014; Skin involvement in lymphomas caused by Marek's disease virus infection in Silkie chickens. J Vet Diagn Invest 26:302–307 [View Article][PubMed]
    [Google Scholar]
  14. Mase M., Mitake H., Inoue T., Imada T. 2009; Identification of group I-III avian adenovirus by PCR coupled with direct sequencing of the hexon gene. J Vet Med Sci 71:1239–1242 [View Article][PubMed]
    [Google Scholar]
  15. Mase M., Nakamura K., Minami F. 2012; Fowl adenoviruses isolated from chickens with inclusion body hepatitis in Japan, 2009–2010. J Vet Med Sci 74:1087–1089 [View Article][PubMed]
    [Google Scholar]
  16. Mazaheri A., Prusas C., Voss M., Hess M. 1998; Some strains of serotype 4 fowl adenoviruses cause inclusion body hepatitis and hydropericardium syndrome in chickens. Avian Pathol 27:269–276 [View Article][PubMed]
    [Google Scholar]
  17. Mittal D., Jindal N., Tiwari A. K., Khokhar R. S. 2014; Characterization of fowl adenoviruses associated with hydropericardium syndrome and inclusion body hepatitis in broiler chickens. Virusdisease 25:114–119 [View Article][PubMed]
    [Google Scholar]
  18. Nakamura K., Mase M., Yamaguchi S., Shibahara T., Yuasa N. 1999; Pathologic study of specific-pathogen-free chicks and hens inoculated with adenovirus isolated from hydropericardium syndrome. Avian Dis 43:414–423 [View Article][PubMed]
    [Google Scholar]
  19. Nakamura K., Tanaka H., Mase M., Imada T., Yamada M. 2002; Pancreatic necrosis and ventricular erosion in adenovirus-associated hydropericardium syndrome of broilers. Vet Pathol 39:403–406 [View Article]
    [Google Scholar]
  20. Ojkic D., Martin E., Swinton J., Vaillancourt J. P., Boulianne M., Gomis S. 2008; Genotyping of Canadian isolates of fowl adenoviruses. Avian Pathol 37:95–100 [View Article][PubMed]
    [Google Scholar]
  21. Ono M., Okuda Y., Shibata I., Sato S., Okada K. 2007; Reproduction of adenoviral gizzard erosion by the horizontal transmission of fowl adenovirus serotype 1. J Vet Med Sci 69:1005–1008 [View Article][PubMed]
    [Google Scholar]
  22. Schachner A., Marek A., Jaskulska B., Bilic I., Hess M. 2014; Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS). Vaccine 32:1086–1092 [View Article][PubMed]
    [Google Scholar]
  23. Schonewille E., Singh A., Göbel T. W., Gerner W., Saalmüller A., Hess M. 2008; Fowl adenovirus (FAdV) serotype 4 causes depletion of B and T cells in lymphoid organs in specific pathogen-free chickens following experimental infection. Vet Immunol Immunopathol 121:130–139 [View Article][PubMed]
    [Google Scholar]
  24. Shahzad A. K. M., Gulzar A., Tarique H., Sarfaraz A. F., Ijaz A., Farhan A. K. 1999; In vivo pathogenicity of hydropericardium-hepatitis syndrome (angara disease) and efficacy of vaccines. Pak Vet J 10:13664–13671
    [Google Scholar]
  25. Smith L. M., Brown S. R., Howes K., McLeod S., Arshad S. S., Barron G. S., Venugopal K., McKay J. C., Payne L. N. 1998; Development and application of polymerase chain reaction (PCR) tests for the detection of subgroup J avian leukosis virus. Virus Res 54:87–98 [View Article][PubMed]
    [Google Scholar]
  26. Steer P. A., Sandy J. R., O'Rourke D., Scott P. C., Browning G. F., Noormohammadi A. H. 2015; Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens. Avian Pathol 44:106–113 [View Article][PubMed]
    [Google Scholar]
  27. Zhao J., Zhong Q., Zhao Y., Hu Y. X., Zhang G. Z. 2015; Pathogenicity and complete genome characterization of fowl Adenoviruses isolated from chickens associated with inclusion body hepatitis and hydropericardium syndrome in China. PLoS One 10:e0133073 [View Article][PubMed]
    [Google Scholar]
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