RT Journal Article SR Electronic(1) A1 Mirabelli, Carmen A1 Pelletier, Isabelle A1 Téoulé, François A1 Vidalain, Pierre-Olivier A1 Brisac, Cynthia A1 Tangy, Frédéric A1 Delpeyroux, Francis A1 Blondel, BrunoYR 2016 T1 The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus JF Journal of General Virology, VO 97 IS 9 SP 2194 OP 2200 DO https://doi.org/10.1099/jgv.0.000544 PB Microbiology Society, SN 1465-2099, AB Poliovirus (PV)-induced apoptosis seems to play a major role in central nervous system (CNS) tissue injury, a crucial feature of the pathogenesis of poliomyelitis. We have previously shown that calcium (Ca2+) flux from the endoplasmic reticulum (ER) to the cytosol during PV infection is involved in apoptosis induction in human neuroblastoma cells. We show here that PV infection is associated with a transient upregulation of Herp (homocysteine-induced ER protein), a protein known to promote the degradation of ER-resident Ca2+ channels. Herp gene transcription is controlled by the transcription factor CREB3 (cAMP response element-binding protein 3). We found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in PV infection. This may reduce the extent of PV-induced damage to the CNS during poliomyelitis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000544