1887

Journal of General Virology

Volume 97, Issue 9

The B-cell response to foot-and-mouth-disease virus in cattle following vaccination and live-virus challenge Open Access

Abstract

Antibodies play a pivotal role against viral infection, and maintenance of protection is dependent on plasma and memory B-cells. Understanding antigen-specific B-cell responses in cattle is essential to inform future vaccine design. We have previously defined T-cell-dependent and -independent B-cell responses in cattle, as a prelude to investigating foot-and-mouth-disease-virus (FMDV)-specific B-cell responses. In this study, we have used an FMDV O-serotype vaccination (O-Manisa or O SKR) and live-virus challenge (FMDV O SKR) to investigate the homologous and heterologous B-cell response in cattle following both vaccination and live-virus challenge. The FMDV O-serotype vaccines were able to induce a cross-reactive plasma-cell response, specific for both O-Manisa and O SKR, post-vaccination. Post-FMDV O SKR live-virus challenge, the heterologous O-Manisa vaccination provided cross-protection against O SKR challenge and cross-reactive O SKR-specific plasma cells were induced. However, vaccination and live-virus challenge were not able to induce a detectable FMDV O-serotype-specific memory B-cell response in any of the cattle. The aim of new FMDV vaccines should be to induce memory responses and increased duration of immunity in cattle.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): B cell , FMDV , T cell , T-independent and viral immunology
© 2016 The Authors
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2016-09-01
2019-10-15
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The B-cell response to foot-and-mouth-disease virus in cattle following vaccination and live-virus challenge
J. Gen. Virol. 97, 2201 (2016); https://doi.org/10.1099/jgv.0.000517
/content/journal/jgv/10.1099/jgv.0.000517
/content/journal/jgv/10.1099/jgv.0.000517
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