RT Journal Article SR Electronic(1) A1 Flipse, Jacky A1 Torres, Silvia A1 Diosa-Toro, Mayra A1 van der Ende-Metselaar, Heidi A1 Herrera-Rodriguez, José A1 Urcuqui-Inchima, Silvio A1 Huckriede, Anke A1 Rodenhuis-Zybert, Izabela A. A1 Smit, Jolanda M.YR 2016 T1 Dengue tropism for macrophages and dendritic cells: the host cell effect JF Journal of General Virology, VO 97 IS 7 SP 1531 OP 1536 DO https://doi.org/10.1099/jgv.0.000474 PB Microbiology Society, SN 1465-2099, AB Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC-derived virus. Taken together, our results highlight the importance of macrophages in dengue infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000474