1887

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Volume 97, Issue 6

A single amino acid change in the hypervariable region 1 of hepatitis C virus genotype 4a aids humoral immune escape Free

Abstract

Longitudinal analysis of chronic hepatitis C virus (HCV) infection has shown that the virus has several adaptive strategies that maintain persistence and infectivity over time. We examined four serum samples from the same chronically infected HCV genotype 4a patient for the presence of IgG antibody-associated virus. RNA was isolated from antibody-associated and antibody-free virions. Subsequent to sequence analysis, 27 aa hypervariable region 1 (HVR1) peptides were used to test the humoral immune escape. We demonstrated that differential peptide binding of Fab was associated with a single amino acid change. We provide direct evidence of natural humoral immune escape by HCV within HVR1.

  • Received:
  • Accepted:
  • Published Online:
© 2016 The Authors
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/content/journal/jgv/10.1099/jgv.0.000447
2016-06-01
2024-04-25
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A single amino acid change in the hypervariable region 1 of hepatitis C virus genotype 4a aids humoral immune escape
J. Gen. Virol. 97, 1345 (2016); https://doi.org/10.1099/jgv.0.000447
/content/journal/jgv/10.1099/jgv.0.000447
/content/journal/jgv/10.1099/jgv.0.000447
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