RT Journal Article SR Electronic(1) A1 Carson, Steven D. A1 Tracy, Steven A1 Kaczmarek, Zac G. A1 Alhazmi, Abdulaziz A1 Chapman, Nora M.YR 2016 T1 Three capsid amino acids notably influence coxsackie B3 virus stability JF Journal of General Virology, VO 97 IS 1 SP 60 OP 68 DO https://doi.org/10.1099/jgv.0.000319 PB Microbiology Society, SN 1465-2099, AB Coxsackievirus B3 strain 28 (CVB3/28) is less stable at 37 °C than eight other CVB3 strains with which it has been compared, including four in this study. In a variant CVB3/28 population selected for increased stability at 37 °C, the capsid proteins of the stable variant differed from the parental CVB3/28 by two mutations in Vp1 and one mutation in Vp3, each of which resulted in altered protein sequences. Each of the amino acid changes was individually associated with a more stable virus. Competition between CVB3/28 and a more stable derivative of the strain showed that propagation of the less stable virus was favoured in receptor-rich HeLa cells., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000319