ORF2 protein of porcine circovirus type 2 promotes phagocytic activity of porcine macrophages by inhibiting proteasomal degradation of complement component 1, q subcomponent binding protein (C1QBP) through physical interaction

References

1. Allan G.M., Ellis J.A. 2000; Porcine circoviruses: a review. J Vet Diagn Invest 12:3–14 [View Article][PubMed]
   [Google Scholar]
2. Allan G.M., Kennedy S., McNeilly F., Foster J.C., Ellis J.A., Krakowka S.J., Meehan B.M., Adair B.M. 1999; Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J Comp Pathol 121:1–11 [View Article][PubMed]
   [Google Scholar]
3. Bierne H., Gouin E., Roux P., Caroni P., Yin H.L., Cossart P. 2001; A role for cofilin and LIM kinase in Listeria-induced phagocytosis. J Cell Biol 155:101–112 [View Article][PubMed]
   [Google Scholar]
4. Bobak D.A., Gaither T.A., Frank M.M., Tenner A.J. 1987; Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J Immunol 138:1150–1156[PubMed]
   [Google Scholar]
5. Bobak D.A., Frank M.M., Tenner A.J. 1988; C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. Eur J Immunol 18:2001–2007 [View Article][PubMed]
   [Google Scholar]
6. Darwich L., Pié S., Rovira A., Segalés J., Domingo M., Oswald I.P., Mateu E. 2003; Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome. J Gen Virol 84:2117–2125 [View Article][PubMed]
   [Google Scholar]
7. Dvorak C.M.T., Puvanendiran S., Murtaugh M.P. 2013; Cellular pathogenesis of porcine circovirus type 2 infection. Virus Res 174:60–68 [View Article][PubMed]
   [Google Scholar]
8. Finsterbusch T., Steinfeldt T., Doberstein K., Rödner C., Mankertz A. 2009; Interaction of the replication proteins and the capsid protein of porcine circovirus type 1 and 2 with host proteins. Virology 386:122–131 [View Article][PubMed]
   [Google Scholar]
9. Ghebrehiwet B., Kew R.R., Gruber B.L., Marchese M.J., Peerschke E.I., Reid K.B. 1995; Murine mast cells express two types of C1q receptors that are involved in the induction of chemotaxis and chemokinesis. J Immunol 155:2614–2619[PubMed]
   [Google Scholar]
10. Ghebrehiwet B., Lim B.L., Kumar R., Feng X., Peerschke E.I. 2001; gC1q-R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection. Immunol Rev 180:65–77 [View Article][PubMed]
    [Google Scholar]
11. Goodman E.B., Tenner A.J. 1992; Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways. J Immunol 148:3920–3928[PubMed]
    [Google Scholar]
12. Guan E.N., Burgess W.H., Robinson S.L., Goodman E.B., McTigue K.J., Tenner A.J. 1991; Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosis. J Biol Chem 266:20345–20355[PubMed]
    [Google Scholar]
13. He J., Cao J., Zhou N., Jin Y., Wu J., Zhou J. 2013; Identification and functional analysis of the novel ORF4 protein encoded by porcine circovirus type 2. J Virol 87:1420–1429 [View Article][PubMed]
    [Google Scholar]
14. Liu J., Chen I., Kwang J. 2005; Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. J Virol 79:8262–8274 [View Article][PubMed]
    [Google Scholar]
15. Liu J., Chen I., Du Q., Chua H., Kwang J. 2006; The ORF3 protein of porcine circovirus type 2 is involved in viral pathogenesis in vivo. J Virol 80:5065–5073 [View Article][PubMed]
    [Google Scholar]
16. Liu J., Zhu Y., Chen I., Lau J., He F., Lau A., Wang Z., Karuppannan A.K., Kwang J. 2007; The ORF3 protein of porcine circovirus type 2 interacts with porcine ubiquitin E3 ligase Pirh2 and facilitates p53 expression in viral infection. J Virol 81:9560–9567 [View Article][PubMed]
    [Google Scholar]
17. Mankertz A., Mankertz J., Wolf K., Buhk H.-J. 1998; Identification of a protein essential for replication of porcine circovirus. J Gen Virol 79:381–384 [View Article][PubMed]
    [Google Scholar]
18. Nawagitgul P., Morozov I., Bolin S.R., Harms P.A., Sorden S.D., Paul P.S. 2000; Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. J Gen Virol 81:2281–2287 [View Article][PubMed]
    [Google Scholar]
19. Opriessnig T., Meng X.J., Halbur P.G. 2007; Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagn Invest 19:591–615 [View Article][PubMed]
    [Google Scholar]
20. Peerschke E.I., Reid K.B., Ghebrehiwet B. 1993; Platelet activation by C1q results in the induction of (IIb/(3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J Exp Med 178:579–587 [View Article][PubMed]
    [Google Scholar]
21. Segalés J., Allan G.M., Domingo M. 2005; Porcine circovirus diseases. Anim Health Res Rev 6:119–142 [View Article][PubMed]
    [Google Scholar]
22. Segalés J., Kekarainen T., Cortey M. 2013; The natural history of porcine circovirus type 2: from an inoffensive virus to a devastating swine disease?. Vet Microbiol 165:13–20 [View Article][PubMed]
    [Google Scholar]
23. Shen Y., Naujokas M., Park M., Ireton K. 2000; InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Cell 103:501–510 [View Article][PubMed]
    [Google Scholar]
24. Tischer I., Bode L., Peters D., Pociuli S., Germann B. 1995; Distribution of antibodies to porcine circovirus in swine populations of different breeding farms. Arch Virol 140:737–743 [View Article][PubMed]
    [Google Scholar]