1887

Abstract

Marine molluscs, like all living organisms, are constantly exposed to viruses and have evolved efficient antiviral defences. We review here recent developments in molluscan antiviral immunity against viruses belonging to the order . Emerging results suggest an interferon-like response and autophagy are involved in the antiviral defence of bivalves to viral infection. Multi-functional plasma proteins from gastropods and bivalves have been identified to have broad-spectrum antiviral activity against mammalian viruses. The antiviral defences present in molluscs can be enhanced by genetic selection, as shown by the presence of oyster strains specifically resistant to ostreid herpesvirus type 1. Whether varying amounts or different isoforms of these antiviral plasma proteins contributes to genetic resistance is worthy of further research. Other evolutionarily conserved antiviral mechanisms, such as RNA interference and apoptosis, still need further characterization.

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2015-09-01
2019-10-20
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References

  1. Arzul I. , Nicolas J.-L. , Davison A.J. , Renault T. . ( 2001a;). French scallops: a new host for ostreid herpesvirus-1. Virology 290: 342–349 [CrossRef] [PubMed].
    [Google Scholar]
  2. Arzul I. , Renault T. , Lipart C. , Davison A.J. . ( 2001b;). Evidence for interspecies transmission of oyster herpesvirus in marine bivalves. J Gen Virol 82: 865–870 [PubMed] [CrossRef]
    [Google Scholar]
  3. Bachère E. , Mialhe E. , Noel D. , Boulo V. , Morvan A. , Rodriguez J. . ( 1995;). Knowledge and research prospects in marine mollusc and crustacean immunology. Aquaculture 132: 17–32 [CrossRef].
    [Google Scholar]
  4. Bachère E. , Rosa R.D. , Schmitt P. , Poirier A.C. , Merou N. , Charrière G.M. , Destoumieux-Garzón D. . ( 2015;). The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view. Fish Shellfish Immunol 46: 50–64. [CrossRef] [PubMed]
    [Google Scholar]
  5. Biron C.A. , Sen G.C. . ( 2001;). Interferons and other cytokines. . In Fields Virology , 4th edn., pp. 321–351. Edited by Knipe D. M. , Howley P. M. , Griffin D. E. , Lamb R. A. , Martin M. A. , Roizman B. , Straus S. E. . Philadelphia, PA: Lippincott Williams & Wilkins;.
    [Google Scholar]
  6. Blair C.D. . ( 2011;). Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission. Future Microbiol 6: 265–277 [CrossRef] [PubMed].
    [Google Scholar]
  7. Breener M. , Fraser D. , van Nieuwenhove K. , O'Beirn F. , Buck B.H. , Mazurie J. , Thoraninsottir G. , Dolmer P. , Sanchez-Mata A. , other authors . ( 2014;). Bivalve aquaculture transfers in Atlantic Europe. Part B: Environmental impacts of transfer activities. Ocean Coast Manage 89: 139–146 [CrossRef].
    [Google Scholar]
  8. Burge C.A. , Griffin F.J. , Friedman C.S. . ( 2006;). Mortality and herpesvirus infections of the Pacific oyster Crassostrea gigas in Tomales Bay, California, USA. Dis Aquat Organ 72: 31–43 [CrossRef] [PubMed].
    [Google Scholar]
  9. Canesi L. , Betti M. , Ciacci C. , Citterio B. , Pruzzo C. , Gallo G. . ( 2003;). Tyrosine kinase-mediated cell signalling in the activation of Mytilus hemocytes: possible role of STAT-like proteins. Biol Cell 95: 603–613 [CrossRef] [PubMed].
    [Google Scholar]
  10. Carriel-Gomes M.C. , Kratz J.M. , Muller V.D.M. , Barardi C.R.M. , Simoes C.M.O. . ( 2006;). Evaluation of antiviral activity in the hemolymph from oysters Crassostrea rhizophorae Crassostreea gigas . Aquat Living Resour 19: 189–193 [CrossRef].
    [Google Scholar]
  11. Chaney M.L. , Gracey A.Y. . ( 2011;). Mass mortality in Pacific oysters is associated with a specific gene expression signature. Mol Ecol 20: 2942–2954 [CrossRef] [PubMed].
    [Google Scholar]
  12. Chang P.H. , Kuo S.T. , Lai S.H. , Yang H.S. , Ting Y.Y. , Hsu C.L. , Chen H.C. . ( 2005;). Herpes-like virus infection causing mortality of cultured abalone Haliotis diversicolor supertexta in Taiwan. Dis Aquat Organ 65: 23–27 [CrossRef] [PubMed].
    [Google Scholar]
  13. Chen G. , Zhang C. , Li C. , Wang C. , Xu Z. , Yan P. . ( 2011;). Haemocyte protein expression profiling of scallop Chlamys farreri response to acute viral necrosis virus (AVNV) infection. Dev Comp Immunol 35: 1135–1145 [CrossRef] [PubMed].
    [Google Scholar]
  14. Chen G. , Wang C. , Zhang C. , Wang Y. , Xu Z. , Wang C. . ( 2013;). A preliminary study of differentially expressed genes of the scallop Chlamys farreri against acute viral necrobiotic virus (AVNV). Fish Shellfish Immunol 34: 1619–1627 [CrossRef] [PubMed].
    [Google Scholar]
  15. Chen G. , Zhang C. , Jiang F. , Wang Y. , Xu Z. , Wang C. . ( 2014;). Bioinformatics analysis of hemocyte miRNAs of scallop Chlamys farreri against acute viral necrobiotic virus (AVNV). Fish Shellfish Immunol 37: 75–86 [CrossRef] [PubMed].
    [Google Scholar]
  16. Coates C.J. , Nairn J. . ( 2014;). Diverse immune functions of hemocyanins. Dev Comp Immunol 45: 43–55 [CrossRef] [PubMed].
    [Google Scholar]
  17. Corporeau C. , Tamayo D. , Pernet F. , Quere C. , Madec S. . ( 2014;). Proteomic signatures of the oyster metabolic response to herpesvirus OsHV-1 μvar infection. J Proteomics 109: 176–187 [CrossRef].
    [Google Scholar]
  18. Crane M.S.J. , Corbeil S. , Williams L.M. , McColl K.A. , Gannon V. . ( 2013;). Evaluation of abalone viral ganglioneuritis resistance among wild abalone populations along the Victorian coast of Australia. J Shellfish Res 32: 67–72 [CrossRef].
    [Google Scholar]
  19. Cullen B.R. . ( 2011;). Viruses and microRNAs: RISCy interactions with serious consequences. Genes Dev 25: 1881–1894 [CrossRef] [PubMed].
    [Google Scholar]
  20. Dang V.T. , Benkendorff K. , Speck P. . ( 2011;). In vitro antiviral activity against herpes simplex virus in the abalone Haliotis laevigata . J Gen Virol 92: 627–637 [CrossRef] [PubMed].
    [Google Scholar]
  21. Dang V.T. , Speck P. , Benkendorff K. . ( 2012;). Influence of elevated temperatures on the immune response of abalone, Haliotis rubra . Fish Shellfish Immunol 32: 732–740 [CrossRef] [PubMed].
    [Google Scholar]
  22. Dang V.T. , Benkendorff K. , Corbeil S. , Williams L.M. , Hoad J. , Crane M.S.J. , Speck P. . ( 2013;). Immunological changes in response to herpesvirus infection in abalone Haliotis laevigata Haliotis rubra hybrids. Fish Shellfish Immunol 34: 688–691 [CrossRef] [PubMed].
    [Google Scholar]
  23. Davison A.J. , Trus B.L. , Cheng N. , Steven A.C. , Watson M.S. , Cunningham C. , Le Deuff R.-M. , Renault T. . ( 2005;). A novel class of herpesvirus with bivalve hosts. J Gen Virol 86: 41–53 [CrossRef] [PubMed].
    [Google Scholar]
  24. Davison A.J. , Eberle R. , Ehlers B. , Hayward G.S. , McGeoch D.J. , Minson A.C. , Pellett P.E. , Roizman B. , Studdert M.J. , Thiry E. . ( 2009;). The order Herpesvirales . Arch Virol 154: 171–177 [CrossRef] [PubMed].
    [Google Scholar]
  25. de Jong D. , Eitel M. , Jakob W. , Osigus H.-J. , Hadrys H. , Desalle R. , Schierwater B. . ( 2009;). Multiple dicer genes in the early-diverging metazoa. Mol Biol Evol 26: 1333–1340 [CrossRef] [PubMed].
    [Google Scholar]
  26. Deddouche S. , Matt N. , Budd A. , Mueller S. , Kemp C. , Galiana-Arnoux D. , Dostert C. , Antoniewski C. , Hoffmann J.A. , Imler J.-L. . ( 2008;). The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nat Immunol 9: 1425–1432 [CrossRef] [PubMed].
    [Google Scholar]
  27. Defer D. , Bourgougnon N. , Fleury Y. . ( 2009;). Screen for antibacterial and antiviral activities in three bivalve and two gastropod marine molluscs. Aquaculture 293: 1–7 [CrossRef].
    [Google Scholar]
  28. Dégremont L. . ( 2011;). Evidence of herpesvirus (OsHV-1) resistance in juvenile Crassostrea gigas selected for high resistance to the summer mortality phenomenon. Aquaculture 317: 94–98 [CrossRef].
    [Google Scholar]
  29. Dégremont L. . ( 2013;). Size and genotype affect resistance to mortality caused by OsHV-1 in Crassostrea gigas . Aquaculture 416: 129–134 [CrossRef].
    [Google Scholar]
  30. Degterev A. , Yuan J. . ( 2008;). Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 9: 378–390 [CrossRef] [PubMed].
    [Google Scholar]
  31. Dostert C. , Jouanguy E. , Irving P. , Troxler L. , Galiana-Arnoux D. , Hetru C. , Hoffmann J.A. , Imler J.-L. . ( 2005;). The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila. Nat Immunol 6: 946–953 [CrossRef] [PubMed].
    [Google Scholar]
  32. Du Y. , Zhang L. , Huang B. , Guan X. , Li L. , Zhang G. . ( 2013;). Molecular cloning, characterization, and expression of two myeloid differentiation factor 88 (MyD88) in Pacific oyster, Crassostrea gigas . J World Aquacult Soc 44: 759–774 [CrossRef].
    [Google Scholar]
  33. Farley C.A. , Banfield W.G. , Kasnic G. Jr , Foster W.S. . ( 1972;). Oyster herpes-type virus. Science 178: 759–760 [CrossRef] [PubMed].
    [Google Scholar]
  34. Fleury E. , Huvet A. . ( 2012;). Microarray analysis highlights immune response of pacific oysters as a determinant of resistance to summer mortality. Mar Biotechnol (NY) 14: 203–217 [CrossRef] [PubMed].
    [Google Scholar]
  35. Fu C. , Song W. , Li Y. . ( 2005;). Monoclonal antibodies developed for detection of an epizootic virus associated with mass mortalities of cultured scallop Chlamys farreri . Dis Aquat Organ 65: 17–22 [CrossRef] [PubMed].
    [Google Scholar]
  36. Garcia C. , Thébault A. , Dégremont L. , Arzul I. , Miossec L. , Robert M. , Chollet B. , François C. , Joly J.-P. , other authors . ( 2011;). Ostreid herpesvirus 1 detection and relationship with Crassostrea gigas spat mortality in France between 1998 and 2006. Vet Res 42: 73–84 [CrossRef] [PubMed].
    [Google Scholar]
  37. Gonzalez M. , Romestand B. , Fievet J. , Huvet A. , Lebart M.C. , Gueguen Y. , Bachère E. . ( 2005;). Evidence in oyster of a plasma extracellular superoxide dismutase which binds LPS. Biochem Biophys Res Commun 338: 1089–1097 [CrossRef] [PubMed].
    [Google Scholar]
  38. Green T.J. , Montagnani C. . ( 2013;). Poly I:C induces a protective antiviral immune response in the Pacific oyster (Crassostrea gigas) against subsequent challenge with Ostreid herpesvirus (OsHV-1 μvar). Fish Shellfish Immunol 35: 382–388 [CrossRef] [PubMed].
    [Google Scholar]
  39. Green T.J. , Benkendorff K. , Robinson N. , Raftos D. , Speck P. . ( 2014a;). Anti-viral gene induction is absent upon secondary challenge with double-stranded RNA in the Pacific oyster, Crassostrea gigas . Fish Shellfish Immunol 39: 492–497 [CrossRef] [PubMed].
    [Google Scholar]
  40. Green T.J. , Montagnani C. , Benkendorff K. , Robinson N. , Speck P. . ( 2014b;). Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas . Fish Shellfish Immunol 36: 151–157 [CrossRef] [PubMed].
    [Google Scholar]
  41. Green T.J. , Robinson N. , Chataway T. , Benkendorff K. , O'Connor W. , Speck P. . ( 2014c;). Evidence that the major hemolymph protein of the Pacific oyster, Crassostrea gigas, has antiviral activity against herpesviruses. Antiviral Res 110: 168–174 [CrossRef] [PubMed].
    [Google Scholar]
  42. He C. , Klionsky D.J. . ( 2009;). Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67–93 [CrossRef] [PubMed].
    [Google Scholar]
  43. He Y. , Jouaux A. , Ford S.E. , Lelong C. , Sourdaine P. , Mathieu M. , Guo X. . ( 2015;). Transcriptome analysis reveals strong and complex antiviral response in a mollusc. Fish Shellfish Immunol 46: 131–144 [CrossRef] [PubMed].
    [Google Scholar]
  44. Hine P.M. , Wesney B. , Hay B.E. . ( 1992;). Herpesvirus associated with mortalities among hatchery-reared larval Pacific oysters Crassostrea gigas . Dis Aquat Organ 12: 135–142 [CrossRef].
    [Google Scholar]
  45. Hooper C. , Hardy-Smith P. , Handlinger J. . ( 2007;). Ganglioneuritis causing high mortalities in farmed Australian abalone (Haliotis laevigata Haliotis rubra). Aust Vet J 85: 188–193 [CrossRef] [PubMed].
    [Google Scholar]
  46. Itoh N. , Xue Q.-G. , Schey K.L. , Li Y. , Cooper R.K. , La Peyre J.F. . ( 2011;). Characterization of the major plasma protein of the eastern oyster, Crassostrea virginica, and a proposed role in host defense. Comp Biochem Physiol B Biochem Mol Biol 158: 9–22 [CrossRef] [PubMed].
    [Google Scholar]
  47. Jeang K.-T. . ( 2012;). RNAi in the regulation of mammalian viral infections. BMC Biol 10: 58–63 [CrossRef] [PubMed].
    [Google Scholar]
  48. Jenkins C. , Hick P. , Gabor M. , Spiers Z. , Fell S.A. , Gu X. , Read A. , Go J. , Dove M. , other authors . ( 2013;). Identification and characterisation of an ostreid herpesvirus-1 microvariant (OsHV-1 μvar) in Crassostrea gigas (Pacific oysters) in Australia. Dis Aquat Organ 105: 109–126 [CrossRef].
    [Google Scholar]
  49. Jouaux A. , Lafont M. , Blin J.-L. , Houssin M. , Mathieu M. , Lelong C. . ( 2013;). Physiological change under OsHV-1 contamination in Pacific oyster Crassostrea gigas through massive mortality events on fields. BMC Genomics 14: 590 [CrossRef] [PubMed].
    [Google Scholar]
  50. Keeling S.E. , Brosnahan C.L. , Williams R. , Gias E. , Hannah M. , Bueno R. , McDonald W.L. , Johnston C. . ( 2014;). New Zealand juvenile oyster mortality associated with ostreid herpesvirus 1 – an opportunistic longitudinal study. Dis Aquat Organ 109: 231–239 [CrossRef] [PubMed].
    [Google Scholar]
  51. Kemp C. , Imler J.-L. . ( 2009;). Antiviral immunity in drosophila. Curr Opin Immunol 21: 3–9 [CrossRef] [PubMed].
    [Google Scholar]
  52. Kemp C. , Mueller S. , Goto A. , Barbier V. , Paro S. , Bonnay F. , Dostert C. , Troxler L. , Hetru C. , other authors . ( 2013;). Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila . J Immunol 190: 650–658 [CrossRef] [PubMed].
    [Google Scholar]
  53. Kingsolver M.B. , Huang Z. , Hardy R.W. . ( 2013;). Insect antiviral innate immunity: pathways, effectors, and connections. J Mol Biol 425: 4921–4936 [CrossRef] [PubMed].
    [Google Scholar]
  54. Kuusksalu A. , Subbi J. , Pehk T. , Reintamm T. , Müller W.E.G. , Kelve M. . ( 1998;). Identification of the reaction products of (2′-5′) oligoadenylate synthetase in the marine sponge. Eur J Biochem 257: 420–426 [CrossRef] [PubMed].
    [Google Scholar]
  55. Lamiable O. , Imler J.-L. . ( 2014;). Induced antiviral innate immunity in Drosophila . Curr Opin Microbiol 20: 62–68 [CrossRef] [PubMed].
    [Google Scholar]
  56. Le Deuff R.-M. , Renault T. . ( 1999;). Purification and partial genome characterization of a herpes-like virus infecting the Japanese oyster, Crassostrea gigas . J Gen Virol 80: 1317–1322 [PubMed] [CrossRef]
    [Google Scholar]
  57. Lieb B. , Todt C. . ( 2008;). Hemocyanin in mollusks – a molecular survey and new data on hemocyanin genes in Solenogastres and Caudofoveata. Mol Phylogenet Evol 49: 382–385 [CrossRef] [PubMed].
    [Google Scholar]
  58. Loker E.S. , Adema C.M. , Zhang S.-M. , Kepler T.B. . ( 2004;). Invertebrate immune systems – not homogeneous, not simple, not well understood. Immunol Rev 198: 10–24 [CrossRef] [PubMed].
    [Google Scholar]
  59. Martenot C. , Oden E. , Travaillé E. , Malas J.P. , Houssin M. . ( 2011;). Detection of different variants of Ostreid Herpesvirus 1 in the Pacific oyster, Crassostrea gigas between 2008 and 2010. Virus Res 160: 25–31 [CrossRef] [PubMed].
    [Google Scholar]
  60. Martín-Gómez L. , Villalba A. , Carballal M.J. , Abollo E. . ( 2014a;). Cloning and characterization of neoplasia-related genes in flat oyster Ostrea edulis . Infect Genet Evol 23: 138–149 [CrossRef] [PubMed].
    [Google Scholar]
  61. Martín-Gómez L. , Villalba A. , Carballal M.J. , Abollo E. . ( 2014b;). Molecular characterisation of TNF, AIF, dermatopontin and VAMP genes of the flat oyster Ostrea edulis and analysis of their modulation by diseases. Gene 533: 208–217 [CrossRef] [PubMed].
    [Google Scholar]
  62. McFarlane S. , Aitken J. , Sutherland J.S. , Nicholl M.J. , Preston V.G. , Preston C.M. . ( 2011;). Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. J Virol 85: 4212–4221 [CrossRef] [PubMed].
    [Google Scholar]
  63. Meister G. , Tuschl T. . ( 2004;). Mechanisms of gene silencing by double-stranded RNA. Nature 431: 343–349 [CrossRef] [PubMed].
    [Google Scholar]
  64. Mineur F. , Provan J. , Arnott G. . ( 2015;). Phylogeographical analyses of shellfish viruses: inferring a geographical origin for ostreid herpesviruses OsHV-1 (Malacoherpesviridae). Mar Biol 162: 181–192.[CrossRef]
    [Google Scholar]
  65. Miyazaki T. , Nozawa N. , Kobayashi T. . ( 2000;). Clinical trial results on the use of a recombinant feline interferon-omega to protect Japanese pearl oysters Pinctada fucata martensii from akoya-virus infection. Dis Aquat Organ 43: 15–26 [CrossRef] [PubMed].
    [Google Scholar]
  66. Moreau P. , Moreau K. , Segarra A. , Tourbiez D. , Travers M.-A. , Rubinsztein D.C. , Renault T. . ( 2015;). Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections. Autophagy 11: 516–526 [CrossRef] [PubMed].
    [Google Scholar]
  67. Nakamoto M. , Moy R.H. , Xu J. , Bambina S. , Yasunaga A. , Shelly S.S. , Gold B. , Cherry S. . ( 2012;). Virus recognition by Toll-7 activates antiviral autophagy in Drosophila . Immunity 36: 658–667 [CrossRef] [PubMed].
    [Google Scholar]
  68. Nakatsugawa T. , Nagai T. , Hiya K. , Nishizawa T. , Muroga K. . ( 1999;). A virus isolated from juvenile Japansese black abalone Nordotis discus discus affected with amyotrophia. Dis Aquat Organ 36: 159–161 [CrossRef].
    [Google Scholar]
  69. Nesterova N.V. , Zagorodnya S.D. , Moshtanska V. , Dolashka P. , Baranova G.V. , Golovan A.V. , Kurova A.O. . ( 2011;). Antiviral activity of hemocyanin isolated from marine snail Rapana venosa . Antiviral Res 90: A38 [CrossRef].
    [Google Scholar]
  70. Normand J. , Li R. , Quillien V. , Nicolas J.-L. , Boudry P. , Pernet F. , Huvet A. . ( 2014;). Contrasted survival under field or controlled conditions displays associations between mRNA levels of candidate genes and response to OsHV-1 infection in the Pacific oyster Crassostrea gigas . Mar Genomics 15: 95–102 [CrossRef] [PubMed].
    [Google Scholar]
  71. Oden E. , Martenot C. , Berthaux M. , Travaille E. , Malas J.P. , Houssin M. . ( 2011;). Quantification of ostreid herpesvirus 1 (OsHV-1) in Crassostrea gigas by real-time PCR: determination of a viral load threshold to prevent summer mortalities. Aquaculture 317: 27–31 [CrossRef].
    [Google Scholar]
  72. Olicard C. , Didier Y. , Marty C. , Bourgougnon N. , Renault T. . ( 2005a;). In vitro research of anti-HSV-1 activity in different extracts from Pacific oysters Crassostrea gigas . Dis Aquat Organ 67: 141–147 [CrossRef] [PubMed].
    [Google Scholar]
  73. Olicard C. , Renault T. , Torhy C. , Benmansour A. , Bourgougnon N. . ( 2005b;). Putative antiviral activity in hemolymph from adult Pacific oysters, Crassostrea gigas . Antiviral Res 66: 147–152 [CrossRef] [PubMed].
    [Google Scholar]
  74. Otsu R. , Sasaki K. . ( 1997;). Virus-like particles detected from juvenile abalones (Nordotis discus discus) reared with an epizootic fatal wasting disease. J Invertebr Pathol 70: 167–168 [CrossRef] [PubMed].
    [Google Scholar]
  75. Owens L. , Malham S. . ( 2015;). Review of the RNA interference pathway in molluscs including some possibilites for use in bivalve aquaculture. J Mar Sci Eng 3: 87–99 [CrossRef].
    [Google Scholar]
  76. Paradkar P.N. , Trinidad L. , Voysey R. , Duchemin J.-B. , Walker P.J. . ( 2012;). Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. Proc Natl Acad Sci U S A 109: 18915–18920 [CrossRef] [PubMed].
    [Google Scholar]
  77. Paradkar P.N. , Duchemin J.-B. , Voysey R. , Walker P.J. . ( 2014;). Dicer-2-dependent activation of Culex Vago occurs via the TRAF-Rel2 signaling pathway. PLoS Negl Trop Dis 8: e2823 [CrossRef] [PubMed].
    [Google Scholar]
  78. Paul-Pont I. , Dhand N.K. , Whittington R.J. . ( 2013;). Influence of husbandry practices on OsHV-1 associated mortality of Pacific oysters Crassostrea gigas . Aquaculture 412-413: 202–214 [CrossRef].
    [Google Scholar]
  79. Paul-Pont I. , Evans O. , Dhand N.K. , Rubio A. , Coad P. , Whittington R. . ( 2014;). Descriptive epidemiology of mass mortality due to Ostreid herpesvirus-1 (OsHV-1) in commercially farmed Pacific oysters (Crassostrea gigas) in the Hawkesbury River estuary. Aust Aquacult 422-423: 146–159 [CrossRef].
    [Google Scholar]
  80. Pauley K.M. , Chan E.K.L. . ( 2008;). MicroRNAs and their emerging roles in immunology. Ann N Y Acad Sci 1143: 226–239 [CrossRef] [PubMed].
    [Google Scholar]
  81. Peeler E.J. , Reese R.A. , Cheslett D.L. , Geoghegan F. , Power A. , Thrush M.A. . ( 2012;). Investigation of mortality in Pacific oysters associated with Ostreid herpesvirus-1 μVar in the Republic of Ireland in 2009. Prev Vet Med 105: 136–143 [CrossRef] [PubMed].
    [Google Scholar]
  82. Pernet F. , Barret J. , Le Gall P. , Corporeau C. , Dégremont L. , Lagarde F. , Pépin J.F. , Keck N. . ( 2012;). Mass mortalities of Pacific oysters Crassostrea gigas reflect infectious diseases and vary with farming practices in the Mediterranean Thau lagoon, France. Aquacult Environ Interact 2: 215–237 [CrossRef].
    [Google Scholar]
  83. Petton B. , Pernet F. , Robert R. , Boudry P. . ( 2013;). Temperature influence on pathogen transmission and subsequent mortalities in juvenile Pacific oysters Crassostrea gigas . Aquacult Environ Interact 3: 257–273 [CrossRef].
    [Google Scholar]
  84. Philipp E.E.R. , Abele D. . ( 2010;). Masters of longevity: lessons from long-lived bivalves – a mini-review. Gerontology 56: 55–65 [CrossRef] [PubMed].
    [Google Scholar]
  85. Quinlan M.P. . ( 1999;). Apoptosis and virus infection. . In Encyclopedia of Virology, pp. 68–76. Edited by Granoff A. , Webster R. G. . Webster Madison, WI: Academic Press; [CrossRef].
    [Google Scholar]
  86. Randall R.E. , Goodbourn S. . ( 2008;). Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89: 1–47 [PubMed].[CrossRef]
    [Google Scholar]
  87. Ren W. , Chen H. , Renault T. , Cai Y. , Bai C. , Wang C. , Huang J. . ( 2013;). Complete genome sequence of acute viral necrosis virus associated with massive mortality outbreaks in the Chinese scallop, Chlamys farreri . Virol J 10: 110 [CrossRef] [PubMed].
    [Google Scholar]
  88. Renault T. , Novoa B. . ( 2004;). Viruses infecting bivalve molluscs. Aquat Living Resour 17: 397–409 [CrossRef].
    [Google Scholar]
  89. Renault T. , Cochennec N. , Le Deuff R.-M. , Chollet B. . ( 1994;). Herpes-like virus infecting Japanese oyster (Crassostrea gigas) spat. Bull Eur Assn Fish Pathol 14: 64–66.
    [Google Scholar]
  90. Renault T. , Lipart C. , Arzul I. . ( 2001;). A herpes-like virus infects a non-ostreid bivalve species: virus replication in Ruditapes philippinarum larvae. Dis Aquat Organ 45: 1–7 [CrossRef] [PubMed].
    [Google Scholar]
  91. Renault T. , Faury N. , Barbosa-Solomieu V. , Moreau K. . ( 2011;). Suppression substractive hybridisation (SSH) and real time PCR reveal differential gene expression in the Pacific cupped oyster, Crassostrea gigas, challenged with Ostreid herpesvirus 1. Dev Comp Immunol 35: 725–735 [CrossRef] [PubMed].
    [Google Scholar]
  92. Renault T. , Moreau P. , Faury N. , Pepin J.-F. , Segarra A. , Webb S. . ( 2012;). Analysis of clinical ostreid herpesvirus 1 (Malacoherpesviridae) specimens by sequencing amplified fragments from three virus genome areas. J Virol 86: 5942–5947 [CrossRef] [PubMed].
    [Google Scholar]
  93. Richetta C. , Faure M. . ( 2013;). Autophagy in antiviral innate immunity. Cell Microbiol 15: 368–376 [CrossRef] [PubMed].
    [Google Scholar]
  94. Robalino J. , Browdy C.L. , Prior S. , Metz A. , Parnell P. , Gross P. , Warr G. . ( 2004;). Induction of antiviral immunity by double-stranded RNA in a marine invertebrate. J Virol 78: 10442–10448 [CrossRef] [PubMed].
    [Google Scholar]
  95. Robertsen B. . ( 2006;). The interferon system of teleost fish. Fish Shellfish Immunol 20: 172–191 [CrossRef] [PubMed].
    [Google Scholar]
  96. Robertsen B. . ( 2008;). Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination. Fish Shellfish Immunol 25: 351–357 [CrossRef] [PubMed].
    [Google Scholar]
  97. Rosani U. , Varotto L. , Domeneghetti S. , Arcangeli G. , Pallavicini A. , Venier P. . ( 2015;). Dual analysis of host and pathogen transcriptomes in ostreid herpesvirus 1-positive Crassostrea gigas . Environ Microbiol. [CrossRef]
    [Google Scholar]
  98. Sauvage C. , Boudry P. , de Koning D.-J. , Haley C.S. , Heurtebise S. , Lapègue S. . ( 2010;). QTL for resistance to summer mortality and OsHV-1 load in the Pacific oyster (Crassostrea gigas). Anim Genet 41: 390–399 [PubMed].
    [Google Scholar]
  99. Savin K.W. , Cocks B.G. , Wong F. , Sawbridge T. , Cogan N. , Savage D. , Warner S. . ( 2010;). A neurotropic herpesvirus infecting the gastropod, abalone, shares ancestry with oyster herpesvirus and a herpesvirus associated with the amphioxus genome. Virol J 7: 308 [CrossRef] [PubMed].
    [Google Scholar]
  100. Schmitt P. , Gueguen Y. , Desmarais E. , Bachère E. , de Lorgeril J. . ( 2010;). Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas . BMC Evol Biol 10: 23 [CrossRef] [PubMed].
    [Google Scholar]
  101. Schoggins J.W. , Rice C.M. . ( 2011;). Interferon-stimulated genes and their antiviral effector functions. Curr Opin Virol 1: 519–525 [CrossRef] [PubMed].
    [Google Scholar]
  102. Segarra A. , Pépin J.F. , Arzul I. , Morga B. , Faury N. , Renault T. . ( 2010;). Detection and description of a particular Ostreid herpesvirus 1 genotype associated with massive mortality outbreaks of Pacific oysters, Crassostrea gigas, in France in 2008. Virus Res 153: 92–99 [CrossRef] [PubMed].
    [Google Scholar]
  103. Segarra A. , Baillon L. , Tourbiez D. , Benabdelmouna A. , Faury N. , Bourgougnon N. , Renault T. . ( 2014a;). Ostreid herpesvirus type 1 replication and host response in adult Pacific oysters, Crassostrea gigas . Vet Res 45: 103 [CrossRef] [PubMed].
    [Google Scholar]
  104. Segarra A. , Faury N. , Pépin J.-F. , Renault T. . ( 2014b;). Transcriptomic study of 39 ostreid herpesvirus 1 genes during an experimental infection. J Invertebr Pathol 119: 5–11 [CrossRef] [PubMed].
    [Google Scholar]
  105. Segarra A. , Mauduit F. , Faury N. , Trancart S. , Dégremont L. , Tourbiez D. , Haffner P. , Barbosa-Solomieu V. , Pépin J.-F. , other authors . ( 2014c;). Dual transcriptomics of virus–host interactions: comparing two Pacific oyster families presenting contrasted susceptibility to ostreid herpesvirus 1. BMC Genomics 15: 580–592 [CrossRef] [PubMed].
    [Google Scholar]
  106. Sumpter R. Jr , Levine B. . ( 2010;). Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol 21: 699–711 [CrossRef] [PubMed].
    [Google Scholar]
  107. Suttle C.A. . ( 2007;). Marine viruses – major players in the global ecosystem. Nat Rev Microbiol 5: 801–812 [CrossRef] [PubMed].
    [Google Scholar]
  108. Tallóczy Z. , Virgin H.W. IV , Levine B. . ( 2006;). PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy 2: 24–29 [CrossRef] [PubMed].
    [Google Scholar]
  109. Tamayo D. , Corporeau C. , Petton B. , Quere C. , Pernet F. . ( 2014;). Physiological changes in Pacific oyster Crassostrea gigas exposed to the herpesvirus OsHV-1 μvar. Aquaculture 432: 304–310 [CrossRef].
    [Google Scholar]
  110. Tamura K. , Peterson D. , Peterson N. , Stecher G. , Nei M. , Kumar S. . ( 2011;). mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28: 2731–2739 [CrossRef] [PubMed].
    [Google Scholar]
  111. Tang B. , Liu B. , Wang X. , Yue X. , Xiang J. . ( 2010;). Physiological and immune responses of Zhikong scallop Chlamys farreri to the acute viral necrobiotic virus infection. Fish Shellfish Immunol 29: 42–48 [CrossRef] [PubMed].
    [Google Scholar]
  112. Wang X.-B. , Wu Q. , Ito T. , Cillo F. , Li W.-X. , Chen X. , Yu J.-L. , Ding S.-W. . ( 2010;). RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana . Proc Natl Acad Sci U S A 107: 484–489 [CrossRef] [PubMed].
    [Google Scholar]
  113. Xing J. , Lin T. , Zhan W. . ( 2008;). Variations of enzyme activities in the haemocytes of scallop Chlamys farreri after infection with the acute virus necrobiotic virus (AVNV). Fish Shellfish Immunol 25: 847–852 [CrossRef] [PubMed].
    [Google Scholar]
  114. Yordy B. , Iwasaki A. . ( 2013;). Cell type-dependent requirement of autophagy in HSV-1 antiviral defense. Autophagy 9: 236–238 [CrossRef] [PubMed].
    [Google Scholar]
  115. Yoshino T.P. , Bickham U. , Bayne C.J. . ( 2013;). Molluscan cells in culture: primary cell cultures and cell lines. Can J Zool 91: 391–404 [CrossRef] [PubMed].
    [Google Scholar]
  116. Zagorodnya S.D. , Dolashka P. , Baranova G.V. , Golovan A.V. , Nesterova N.V. . ( 2011;). Anti-EBV activity of hemocyanin isolated from Helix lucorum . Antiviral Res 90: A66.
    [Google Scholar]
  117. Zanjani N.T. , Sairi F. , Marshall G. , Saksena M.M. , Valtchev P. , Gomes V.G. , Cunningham A.L. , Dehghani F. . ( 2014;). Formulation of abalone hemocyanin with high antiviral activity and stability. Eur J Pharm Sci 53: 77–85 [CrossRef] [PubMed].
    [Google Scholar]
  118. Zeng M. , Cui W. , Zhao Y. , Liu Z. , Dong S. , Guo Y. . ( 2008;). Antiviral active peptide from oyster. Chin J Oceanology Limnol 26: 307–312 [CrossRef].
    [Google Scholar]
  119. Zhang L. , Li L. , Zhang G. . ( 2011;). Gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system. Dev Comp Immunol 35: 603–610 [CrossRef] [PubMed].
    [Google Scholar]
  120. Zhang G. , Fang X. , Guo X. , Li L. , Luo R. , Xu F. , Yang P. , Zhang L. , Wang X. , other authors . ( 2012;). The oyster genome reveals stress adaptation and complexity of shell formation. Nature 490: 49–54 [CrossRef] [PubMed].
    [Google Scholar]
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