1887

Abstract

SUMMARY

Antiserum was prepared in rabbits against purified haemagglutinin obtained from A0/ virus. The antiserum had potent virus-neutralizing and haemagglutination-inhibiting activity, but was free of antibody to A0/ neuraminidase or to influenza A type-specific ribonucleoprotein. In immunodiffusion tests, the anti-haemagglutinin serum gave precipitin reactions with all A0 and A1 virus strains tested but did not react with human A2 viruses or avian or porcine influenza A viruses. The studies suggested a close immunological relationship between the haemagglutinins of A0 and A1 influenza viruses which was not revealed by haemagglutination-inhibition tests.

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1970-12-01
2024-12-14
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References

  1. Biddle F. 1968; The action of protease on influenza A2 virus. Journal of General Virology 2:19
    [Google Scholar]
  2. Crowle A. J. 1958; A simplified micro double diffusion agar precipitin technique. Journal of Laboratory and Clinical Medicine 52:784
    [Google Scholar]
  3. Davenport F. M., Hennessy A. V., Francis T. J. 1953; Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus. Journal of Experimental Medicine 98:641
    [Google Scholar]
  4. Easterday B., Laver W. G., Pereira H. G., Schild G. C. 1969; Antigenic composition of recombinant virus strains produced from human and avian influenza A viruses. Journal of General Virology 5:83
    [Google Scholar]
  5. Haukenes G., Harboe A., Mortensson-Egnund K. 1966; A uronic and sialic acid free chick allantoic mucopolysaccharide sulphate which combines with influenza virus H 1-antibody to host material. Acta pathologica et microbiologica scandinavica 66:510
    [Google Scholar]
  6. Jensen K. E., Davenport F. M., Hennessy A. V., Francis T. Jun. 1956; Characterization of influenza antibodies by serum absorption. Journal of Experimental Medicine 104:199
    [Google Scholar]
  7. Laver W. G. 1963; The structure of influenza viruses. III. Disruption of virus particle and separation of neuraminidase activity. Virology 20:251
    [Google Scholar]
  8. Laver W. G. 1964; Structural studies on the protein subunits from three strains of influenza virus. Journal of Molecular Biology 9:109
    [Google Scholar]
  9. Laver W. G., Kilbourne E. D. 1966; Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology 30:493
    [Google Scholar]
  10. Laver W. G., Valentine R. C. 1969; Morphology of the isolated haemagglutinin and neuraminidase subunits of influenza. Virology 38:105
    [Google Scholar]
  11. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 193:265
    [Google Scholar]
  12. Paniker C. K. J. 1968; Serological relationships between the neuraminidases of influenza viruses. Journal of General Virology 2:385
    [Google Scholar]
  13. Seto J. T., Drzeniek R., Rott R. 1966; Isolation of a low molecular weight sialidase (neuraminidase) from influenza virus. Biochemica et biophysica Acta 113:402
    [Google Scholar]
  14. Schild G. C., Newman R. W. 1969; Immunological relationships between the neuraminidases of human and animal influenza viruses. Bulletin of the World Health Organisation 41:437
    [Google Scholar]
  15. Schild G. C., Mccahon D. 1970; Immunological and structural studies on a recombinant between human A0 and A2 influenza virus. In Symposium on Large RNA Viruses New York and London: Academic Press; (In the Press)
    [Google Scholar]
  16. Schild G. C., Pereira H. G. 1969; Characterization of the ribonucleoprotein and neuraminidase of influenza viruses by immunodiffusion. Journal of General Virology 4:355
    [Google Scholar]
  17. Schild G. C., Stuart-Harris C. H. 1965; Serological epidemiology of influenza A viruses. Journal of Hygiene 63:479
    [Google Scholar]
  18. Schulman J. L., Kilbourne E. D. 1965; Induction of partial specific heterotypic immunity in mice by a single infection with influenza A virus. Journal of Bacteriology 89:170
    [Google Scholar]
  19. Warren L. 1959; The thiobarbituric acid assay of sialic acids. Journal of Biological Chemistry 234:1971
    [Google Scholar]
  20. Webster R. G. 1968; The immune response of influenza virus. III. Changes in the avidity and specificity of early IgM and IgG antibodies. Immunology 14:39
    [Google Scholar]
  21. Webster R. G., Laver W. G. 1967; Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. Journal of Immunology 99:49
    [Google Scholar]
  22. Webster R. G., Pereira H. G. 1968; A common surface antigen in influenza viruses from human and avian sources. Journal of General Virology 3:201
    [Google Scholar]
  23. W.H.O. expert committee on influenza 1953 Technical Report Series of World Health Organisation no 64
    [Google Scholar]
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