1887

Abstract

Virus ribonucleic acid molecules are known to induce formation of interferon. Previous reports have demonstrated the inducing activity of the double-stranded RNA extracted from reovirus (Tytell, 1967), or of double-stranded RNA formed within cells infected with RNA or DNA viruses (Field, 1967; Skehel & Burke, 1968; Falcoff & Falcoff, 1969; Colby & Duesberg, 1969). Gandhi & Burke (1970), using u.v.-irradiated fowl plague or Newcastle disease viruses, showed that interferon production occurred in the absence of any detectable RNA synthesis, and the authors suggested that the single-stranded RNA of the virus was the inducer of interferon formation. Lomniczi & Burke (1970) arrived at a similar conclusion using Semliki Forest virus as an inducer. However, Huppert, Hillova & Gresland (1969) reported that u.v.-irradiated Newcastle disease virus which was totally unable to produce infectious virus was still able to synthesize virus RNA in infected cells, as detected by a hybridization method.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-9-1-97
1970-10-01
2019-11-18
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-9-1-97
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error