1887

Abstract

The incidence of testicular germ cell cancer, which is the most common cancer among young male adults, is increasing. The aetiology remains unknown, although a virus has been proposed. A previous study has shown a high prevalence of human parvovirus B19 (B19) DNA in the testes of patients with testicular germ cell tumours (85%) and suggested that B19 may play a role in tumour development. To address this question of causality, seroreactivity to B19 was studied among cases (=80) and controls (=241) using serum samples drawn before the onset of disease, in addition to an elucidation of the frequency of virus DNA in a retrospectively collected 2-year testicular carcinoma series. No association was found between B19 seropositivity and the risk of testicular cancer (odds ratio=1·03; 95% confidence interval=0·60–1·77) nor was there any dose-response relation ( for trend=0·53). This study did, however, confirm the observation that B19 DNA can be detected in testicular carcinoma tissue, as 4 of 24 cases were found to be positive, while no B19 DNA could be detected in the control cases. It is speculated that this finding may be due to susceptibility of the carcinoma cells to B19 virus owing to high-level expression of the viral receptor glycosphingolipid (Gb4) and possible other putative cellular factors resulting in a localized persistence initiated after the development of cancer.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-83-9-2321
2002-09-01
2020-01-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/83/9/0832321a.html?itemId=/content/journal/jgv/10.1099/0022-1317-83-9-2321&mimeType=html&fmt=ahah

References

  1. Adami, H. O., Bergstrom, R., Mohner, M., Zatonski, W., Storm, H., Ekbom, A., Tretli, S., Teppo, L., Ziegler, H., Rahu, M. and others ( 1994; ). Testicular cancer in nine northern European countries. International Journal of Cancer 59, 33–38.[CrossRef]
    [Google Scholar]
  2. Akre, O., Lipworth, L., Tretli, S., Linde, A., Engstrand, L., Adami, H. O., Melbye, M., Andersen, A. & Ekbom, A. ( 1999; ). Epstein–Barr virus and cytomegalovirus in relation to testicular-cancer risk: a nested case-control study. International Journal of Cancer 82, 1-5.[CrossRef]
    [Google Scholar]
  3. Anderson, M. J., Lewis, E., Kidd, I. M., Hall, S. M. & Cohen, B. J. ( 1984; ). An outbreak of erythema infectiosum associated with human parvovirus infection. Journal of Hygiene 93, 85-93.[CrossRef]
    [Google Scholar]
  4. Broliden, K., Tolfvenstam, T., Ohlsson, S. & Henter, J. I. ( 1998; ). Persistent B19 parvovirus infection in pediatric malignancies. Medical and Pediatric Oncology 31, 66-72.[CrossRef]
    [Google Scholar]
  5. Brown, K. E., Anderson, S. M. & Young, N. S. ( 1993; ). Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262, 114-117.[CrossRef]
    [Google Scholar]
  6. Cohen, B. J. & Buckley, M. M. ( 1988; ). The prevalence of antibody to human parvovirus B19 in England and Wales. Journal of Medical Microbiology 25, 151-153.[CrossRef]
    [Google Scholar]
  7. Cooling, L. L., Koerner, T. A. & Naides, S. J. ( 1995; ). Multiple glycosphingolipids determine the tissue tropism of parvovirus B19. Journal of Infectious Diseases 172, 1198-1205.[CrossRef]
    [Google Scholar]
  8. Diss, T. C., Pan, L. X., Du, M. Q., Peng, H. Z. & Kerr, J. R. ( 1999; ). Parvovirus B19 is associated with benign testes as well as testicular germ cell tumours. Molecular Pathology 52, 349-352.[CrossRef]
    [Google Scholar]
  9. Ehrlich, H. & Bugawan, T. ( 1989; ). HLA class II gene polymorphism: DNA typing, evolution and relationship to disease susceptibility. In PCR Technology: Principles and Applications for DNA amplification , pp. 193-208. Edited by H. A. Ehrlich. Oxford: Oxford University Press.
  10. Gray, A., Guillou, L., Zufferey, J., Rey, F., Kurt, A. M., Jichlinski, P., Leisinger, H. J. & Benhattar, J. ( 1998; ). Persistence of parvovirus B19 DNA in testis of patients with testicular germ cell tumours. Journal of General Virology 79, 573-579.
    [Google Scholar]
  11. Jellum, E., Andersen, A., Lund-Larsen, P., Theodorsen, L. & Orjasaeter, H. ( 1995; ). Experiences of the Janus Serum Bank in Norway. Environmental Health Perspectives 103 (Suppl. 3), 85–88.
    [Google Scholar]
  12. Kurtzman, G. J., Ozawa, K., Cohen, B., Hanson, G., Oseas, R. & Young, N. S. ( 1987; ). Chronic bone marrow failure due to persistent B19 parvovirus infection. New England Journal of Medicine 317, 287-294.[CrossRef]
    [Google Scholar]
  13. Lundqvist, A., Tolfvenstam, T., Bostic, J., Soderlund, M. & Broliden, K. ( 1999; ). Clinical and laboratory findings in immunocompetent patients with persistent parvovirus B19 DNA in bone marrow. Scandinavian Journal of Infectious Diseases 31, 11-16.[CrossRef]
    [Google Scholar]
  14. Morey, A. L., Keeling, J. W., Porter, H. J. & Fleming, K. A. ( 1992; ). Clinical and histopathological features of parvovirus B19 infection in the human fetus. British Journal of Obstetrics and Gynaecology 99, 566-574.[CrossRef]
    [Google Scholar]
  15. Newell, G. R., Mills, P. K. & Johnson, D. E. ( 1984; ). Epidemiologic comparison of cancer of the testis and Hodgkin′s disease among young males. Cancer 54, 1117-1123.[CrossRef]
    [Google Scholar]
  16. Ohyama, C., Fukushi, Y., Satoh, M., Saitoh, S., Orikasa, S., Nudelman, E., Straud, M. & Hakomori, S. ( 1990; ). Changes in glycolipid expression in human testicular tumor. International Journal of Cancer 45, 1040-1044.[CrossRef]
    [Google Scholar]
  17. Olie, R. A., Fenderson, B., Daley, K., Oosterhuis, J. W., Murphy, J. & Looijenga, L. H. ( 1996; ). Glycolipids of human primary testicular germ cell tumours. British Journal of Cancer 74, 133-140.[CrossRef]
    [Google Scholar]
  18. Pallier, C., Greco, A., Le Junter, J., Saib, A., Vassias, I. & Morinet, F. ( 1997; ). The 3′ untranslated region of the B19 parvovirus capsid protein mRNAs inhibits its own mRNA translation in nonpermissive cells. Journal of Virology 71, 9482-9489.
    [Google Scholar]
  19. Tolfvenstam, T., Papadogiannakis, N., Norbeck, O., Petersson, K. & Broliden, K. ( 2001; ). Frequency of human parvovirus B19 infection in intrauterine fetal death. Lancet 357, 1494-1497.[CrossRef]
    [Google Scholar]
  20. Weigel-Kelley, K. A., Yoder, M. C. & Srivastava, A. ( 2001; ). Recombinant human parvovirus B19 vectors: erythrocyte P antigen is necessary but not sufficient for successful transduction of human hematopoietic cells. Journal of Virology 75, 4110-4116.[CrossRef]
    [Google Scholar]
  21. Wenk, J., Andrews, P. W., Casper, J., Hata, J., Pera, M. F., von Keitz, A., Damjanov, I. & Fenderson, B. A. ( 1994; ). Glycolipids of germ cell tumors: extended globo-series glycolipids are a hallmark of human embryonal carcinoma cells. International Journal of Cancer 58, 108-115.[CrossRef]
    [Google Scholar]
  22. Young, N. ( 1988; ). Hematologic and hematopoietic consequences of B19 parvovirus infection. Seminars in Hematology 25, 159-172.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-83-9-2321
Loading
/content/journal/jgv/10.1099/0022-1317-83-9-2321
Loading

Data & Media loading...

Most cited articles

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error