1887

Abstract

The maedi–visna lentivirus (MVV) induces encephalitis, interstitial pneumonia, arthritis and mastitis in sheep. While some MVV strains can enter cells of ruminant species only, others can enter cells from many species, including human, but not Chinese hamster cells. However, the identity of the receptor(s) used by MVV for entry is unknown. The MVV-K1514 receptor gene was localized in sheep and human chromosomes using hamster×sheep and hamster×human hybrid cell lines. Based on entry by a vector pseudotyped with the MVV-K1514 envelope, the MVV-K1514 receptor gene was mapped to sheep chromosome 3p and to a region of human chromosome 2 (2p25>q13), which has conserved synteny with sheep chromosome 3p. These regions do not include any known lentivirus receptor or coreceptor gene, indicating that MVV-K1514 uses a new lentivirus receptor to infect human cells.

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2002-07-01
2019-10-22
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References

  1. Andresson, O. S., Elser, J. E., Tobin, G. J., Greenwood, J. D., Gonda, M. A., Georgsson, G., Andrésdóttir, V., Benediktsdóttir, E., Carlsdóttir, H. M., Mäntylä, E. O., Rafnar, B., Pálsson, P. A., Casey, J. W. & Pétursson, G. ( 1993; ). Nucleotide sequence and biological properties of a pathogenic proviral molecular clone of neurovirulent visna virus. Virology 193, 89-105.[CrossRef]
    [Google Scholar]
  2. Band, M. R., Larson, J. H., Rebeiz, M., Green, C. A., Heyen, D. W., Donovan, J., Windish, R., Steining, C., Mahyuddin, P., Womack, J. E. & Lewin, H. A. ( 2000; ). An ordered comparative map of the cattle and human genomes. Genome Research 10, 1359-1368.[CrossRef]
    [Google Scholar]
  3. Barber, S. A., Bruett, L. & Clements, J. E. ( 2000; ). Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus. Virology 274, 321-330.[CrossRef]
    [Google Scholar]
  4. Broad, T. E., Burkin, D. J., Jones, C., Lewis, P. E., Ansari, H. A. & Pearce, P. D. ( 1993; ). Mapping of MYF5, C1R, MYHL, TPI1, IAPP, A2MR and RNR onto sheep chromosome 3q. Animal Genetics 24, 415-419.
    [Google Scholar]
  5. Broad, T. E., Burkin, D. J., Cambridge, L. M., Jones, C., Lewis, P. E., Morse, H. G., Geyer, D., Pearce, P. D., Ansari, H. A. & Maher, D. W. ( 1995; ). Six loci mapped on to human chromosome 2p are assigned to sheep chromosome 3p. Animal Genetics 26, 85-90.
    [Google Scholar]
  6. Brodie, S. J., Pearson, L. D., Zink, M. C., Bickle, H. M., Anderson, B. C., Marcom, K. A. & DeMartini, J. C. ( 1995; ). Ovine lentivirus expression and disease. Virus replication, but not entry, is restricted to macrophages of specific tissues. American Journal of Pathology 146, 250-263.
    [Google Scholar]
  7. Bruett, L. & Clements, J. E. ( 2001; ). Functional murine leukemia virus vectors pseudotyped with the visna envelope show expanded visna virus cell tropism. Journal of Virology 75, 11464-11473.[CrossRef]
    [Google Scholar]
  8. Bruett, L., Barber, S. A. & Clements, J. E. ( 2000; ). Characterization of a membrane-associated protein implicated in visna virus binding and infection. Virology 271, 132-141.[CrossRef]
    [Google Scholar]
  9. Burkin, D. J., Broad, T. E., Lambeth, M. R., Burkin, H. R. & Jones, C. ( 1998; ). New gene assignments using a complete, characterized sheep–hamster somatic cell hybrid panel. Animal Genetics 29, 48-54.[CrossRef]
    [Google Scholar]
  10. Crane, S. E., Buzy, J. & Clements, J. E. ( 1991; ). Identification of cell membrane proteins that bind visna virus. Journal of Virology 65, 6137-6143.
    [Google Scholar]
  11. Gendelman, H. E., Narayan, O., Molineaux, S., Clements, J. E. & Ghotbi, Z. ( 1985; ). Slow, persistent replication of lentiviruses: role of tissue macrophages precursors in bone marrow. Proceedings of the National Academy of Sciences, USA 82, 7086-7090.[CrossRef]
    [Google Scholar]
  12. Gendelman, H. E., Narayan, O., Kennedy-Stoskopf, S., Kennedy, P. G. E., Ghotbi, Z., Clements, J. E., Stanley, J. & Pezeshkpour, G. ( 1986; ). Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. Journal of Virology 58, 67-74.
    [Google Scholar]
  13. Georgsson, G., Houwers, D. J., Pálsson, P. A. & Pétursson, G. ( 1989; ). Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimental visna induced by virus strains of increased neurovirulence. Acta Neuropathologica 77, 299-306.[CrossRef]
    [Google Scholar]
  14. Gorrell, M. D., Brandon, M. R., Sheffer, D., Adams, R. J. & Narayan, O. ( 1992; ). Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes. Journal of Virology 66, 2679-2688.
    [Google Scholar]
  15. Hötzel, I. & Cheevers, W. P. ( 2001; ). Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis–encephalitis virus pseudotype system. Journal of Virology 75, 7384-7391.[CrossRef]
    [Google Scholar]
  16. Lopez-Corrales, N. L., Sonstegard, T. S. & Smith, T. P. ( 1998; ). Comparative gene mapping: cytogenetic localization of PROC, EN1, ALPI, TNP1, and IL1B in cattle and sheep reveals a conserved rearrangement relative to the human genome. Cytogenetics and Cell Genetics 83, 35-38.[CrossRef]
    [Google Scholar]
  17. Lopez-Corrales, N. L., Sonstegard, T. S. & Smith, T. P. ( 1999; ). Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8. Cytogenetics and Cell Genetics 84, 179-181.[CrossRef]
    [Google Scholar]
  18. Lyall, J. W., Solansky, N. & Tiley, L. S. ( 2000; ). Restricted species tropism of maedi–visna virus strain EV-1 is not due to limited receptor distribution. Journal of General Virology 81, 2919-2927.
    [Google Scholar]
  19. MacIntyre, E. H., Wintersgill, C. J. & Thormar, H. ( 1972; ). Morphological transformation of human astrocytes by visna virus with complete virus production. Nature New Biology 237, 111-113.[CrossRef]
    [Google Scholar]
  20. Marin, M., Tailor, C. S., Nouri, A. & Kabat, D. ( 2000; ). Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. Journal of Virology 74, 8085-8093.[CrossRef]
    [Google Scholar]
  21. Narayan, O., Zink, M., Gorrell, M., Crane, S., Huso, D., Jolly, P., Saltarelli, M., Adams, R. & Clements, J. ( 1993; ). The lentiviruses of sheep and goats. In The Retroviridae , pp. 229-256. Edited by J. A. Levy. New York:Plenum.
  22. Peden, K. W. C. & Farber, J. M. ( 2000; ). Coreceptors for human immunodeficiency virus and simian immunodeficiency virus. Advances in Pharmacology 48, 409-478.
    [Google Scholar]
  23. Ryan, S., Tiley, L., McConnell, I. & Blacklaws, B. ( 2000; ). Infection of dendritic cells by the maedi–visna lentivirus. Journal of Virology 74, 10096-10103.[CrossRef]
    [Google Scholar]
  24. Sommerfelt, M. A. ( 1999; ). Retrovirus receptors. Journal of General Virology 80, 3049-3064.
    [Google Scholar]
  25. Willett, B. J., Hosie, M. J., Neil, J. C., Turner, J. D. & Hoxie, J. A. ( 1997a; ). Common mechanism of infection by lentiviruses. Nature 385, 587.
    [Google Scholar]
  26. Willett, B. J., Picard, L., Hosie, M. J., Turner, J. D., Adema, K. & Clapham, P. R. ( 1997b; ). Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. Journal of Virology 71, 6407-6415.
    [Google Scholar]
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