RT Journal Article SR Electronic(1) A1 Stevenson, P. G. A1 Austyn, J. M. A1 Hawke, S.YR 2002 T1 Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma JF Journal of General Virology, VO 83 IS 7 SP 1735 OP 1743 DO https://doi.org/10.1099/0022-1317-83-7-1735 PB Microbiology Society, SN 1465-2099, AB Non-neuroadapted influenza virus confined to the brain parenchyma does not induce antigen-specific immunity. Nevertheless, infection in this site upregulated major histocompatibility complex (MHC) class I and MHC class II expression and recruited lymphocytes to a perivascular compartment. T cells recovered from the brain had an activated/memory phenotype but did not respond to viral antigens. In contrast, T cells recovered from the brain after infection in a lateral cerebral ventricle, which is immunogenic, showed virus-specific responses. As with infectious virus, influenza virus-infected dendritic cells elicited virus-specific immunity when inoculated into the cerebrospinal fluid but not when inoculated into the brain parenchyma. Thus, inflammation and dendritic cell function were both uncoupled from immune priming in the microenvironment of the brain parenchyma and neither was sufficient to overcome immunological privilege., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-83-7-1735