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Journal of General Virology header logo Journal of General Virology

Volume 83, Issue 7

Mixed patterns of transmission of human herpesvirus-8 (Kaposi’s sarcoma-associated herpesvirus) in Malawian families No Access

Abstract

To study transmission patterns of human herpesvirus-8 (HHV-8) (Kaposi’s sarcoma-associated herpesvirus) in families in Malawi, nucleotide sequences derived from two hypervariable loci of the HHV-8 genome, the V1 and V2 regions of open reading frame K1 (K1/V1 and K1/V2, respectively), were amplified from blood and mouth rinse samples of 22 patients with treated and untreated Kaposi’s sarcoma (KS) and their first-degree relatives (=67). In patients with KS, vincristine therapy was significantly associated with non-detectability of circulating, but not oral, K1/V1 DNA. Intra-familial K1/V1 phylogenetic comparisons of eight families were possible. Both identical and non-identical sequences were observed between family members, suggesting transmission of HHV-8 along both intra- and extra-familial transmission routes.

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© Microbiology Society
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2002-07-01
2025-05-14
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/content/journal/jgv/10.1099/0022-1317-83-7-1613
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Mixed patterns of transmission of human herpesvirus-8 (Kaposi’s sarcoma-associated herpesvirus) in Malawian families
J. Gen. Virol. 83, 1613 (2002); https://doi.org/10.1099/0022-1317-83-7-1613
/content/journal/jgv/10.1099/0022-1317-83-7-1613
/content/journal/jgv/10.1099/0022-1317-83-7-1613
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