1887

Abstract

A survey of poliovirus in river and sewage water was conducted from October 1993 to September 1995 in Toyama Prefecture, Japan. In this study, 25 isolates differentiated as type 2 vaccine-derived polioviruses (VDPVs) were characterized using mutant analysis by PCR and restriction-enzyme cleavage (MAPREC) to estimate the ratio of 481-G revertants correlated to neurovirulence in a virus population. Of these isolates, 23 (92%) comprised between 44 and 96% 481-G revertants by MAPREC. The other two isolates had revertant percentages close to the 0·6% of the attenuated reference strain. It was presumed that these 23 isolates would be variant with potential neurovirulence by MAPREC analysis. Of the 23 isolates, three were isolated from river water. Moreover, our results by MAPREC showed that type 2 poliovirus was phenotypically more variable than type 1 (69%) or type 3 (55%), as determined in previous studies. The prevalence of virulent-type VDPVs in river and sewage water suggested that the oral poliovaccine itself had led to wide environmental pollution in nature. To terminate the cycle of virus transmission in nature, the ecology of VDPVs should be studied further. A hygiene programme, inactivated poliovirus vaccine immunization and well-maintained herd immunity may play key roles in reducing the potential risk of infection by virulent VDPVs.

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2002-05-01
2019-10-13
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References

  1. Abraham, R., Minor, P., Dunn, G., Modlin, J. F. & Ogra, P. L. ( 1993; ). Shedding of virulent poliovirus revertants during immunization with oral poliovirus vaccine after prior immunization with inactivated polio vaccine. Journal of Infectious Diseases 168, 1105-1109.[CrossRef]
    [Google Scholar]
  2. Benyesh-Melnick, M., Melnick, J. L., Rawls, W. E., Wimberly, I., Oro, J. B., Ben-Porath, E. & Rennick, V. ( 1967; ). Studies of the immunogenicity, communicability and genetic stability of oral poliovaccine administration during the winter. American Journal of Epidemiology 86, 112-136.
    [Google Scholar]
  3. Brancroft, P. M., Engelhard, W. E. & Evans, C. A. ( 1957; ). Poliomyelitis in Huskerville (Lincoln) Nebraska. Studies indicating a relationship between clinically severe infection and proximate fecal pollution of water. Journal of the American Medical Association 164, 836-847.[CrossRef]
    [Google Scholar]
  4. Centers for Disease Control & Prevention ( 2000; ). Outbreak of poliomyelitis – Dominican Republic and Haiti, 2000. Morbidity and Mortality Weekly Report 49, 1094, 1103.
    [Google Scholar]
  5. Centers for Disease Control & Prevention ( 2001; ). Circulation of a type 2 vaccine-derived poliovirus – Egypt, 1982–1993. Morbidity and Mortality Weekly Report 50, 41–42, 51.
    [Google Scholar]
  6. Chumakov, K. M. ( 1999; ). Molecular consistency monitoring of oral poliovirus vaccine and other live viral vaccines. Developments in Biological Standardization 100, 67-74.
    [Google Scholar]
  7. Chumakov, K. M., Powers, L. B., Noonan, K. E., Roninson, I. B. & Levenbook, I. S. ( 1991; ). Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. Proceedings of the National Academy of Sciences, USA 88, 199-203.[CrossRef]
    [Google Scholar]
  8. Chumakov, K. M., Dragunsky, E. M., Norwood, L. P., Douthitt, M. P., Ran, Y., Taffs, R. E., Ridge, J. & Levenbook, I. S. ( 1994; ). Consistent selection of mutations in the 5′-untranslated region of oral poliovirus vaccine upon passaging in vitro. Journal of Medical Virology 42, 79-85.[CrossRef]
    [Google Scholar]
  9. Divizia, M., Palombi, L., Buonomo, E., Donia, D., Ruscio, V., Equestre, M., Leno, L., Pana, A. & Degener, A. M. ( 1999; ). Genomic characterization of human and environmental polioviruses isolated in Albania. Applied and Environmental Microbiology 65, 3534-3539.
    [Google Scholar]
  10. Dunn, G., Begg, N. T., Cammack, N. & Minor, P. D. ( 1990; ). Virus excretion and mutation by infants following primary vaccination with live oral poliovaccine from two sources. Journal of Medical Virology 32, 92-95.[CrossRef]
    [Google Scholar]
  11. Evans, D. M., Dunn, G., Minor, P. D., Schild, G. C., Cann, A. J., Stanway, G., Almond, J. W., Currey, K. & Maizel, J. V.Jr ( 1985; ). Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314, 548-550.[CrossRef]
    [Google Scholar]
  12. Goyal, S. M., Gerba, C. P. & Melnick, J. L. ( 1979; ). Human enteroviruses in oysters and their overlying waters. Applied and Environmental Microbiology 37, 572-581.
    [Google Scholar]
  13. Guillot, S., Otelea, D., Delpeyroux, F. & Crainic, R. ( 1994; ). Point mutations involved in the attenuation/neurovirulence alternation in type 1 and 2 oral polio vaccine strains detected by site-specific polymerase chain reaction. Vaccine 12, 503-507.[CrossRef]
    [Google Scholar]
  14. Haas, C. N. ( 1983; ). Estimation of risk due to low doses of microorganisms: a comparison of alternative methodologies. American Journal of Epidemiology 118, 573-582.
    [Google Scholar]
  15. Haas, C. N. & Heller, B. ( 1988; ). Test of the validity of the Poisson assumption for analysis of most-probable-number results. Applied and Environmental Microbiology 54, 2996-3002.
    [Google Scholar]
  16. Haas, C. N., Rose, J. B., Gerba, C. & Regli, S. ( 1993; ). Risk assessment of virus in drinking water. Risk Analysis 13, 545-552.[CrossRef]
    [Google Scholar]
  17. Horie, H., Yoshida, H., Matsuura, K., Miyazawa, M., Ota, Y., Nakayama, T., Doi, Y. & Hashizume, S. ( 2002; ). Neurovirulence of type 1 polioviruses isolated from sewage in Japan. Applied and Environmental Microbiology 68, 138-142.[CrossRef]
    [Google Scholar]
  18. Japan Live Poliovaccine Research Commission ( 1967; ). Evaluation of Sabin live poliovirus vaccine in Japan. IV. Marker tests on poliovirus strains recovered from vaccinees and their contacts. Marker Test Subcommittee. Japanese Journal of Medical Science and Biology 20, 167–173.[CrossRef]
    [Google Scholar]
  19. Jaykus, L. A. ( 1997; ). Epidemiology and detection as options for control of viral and parasitic foodborne disease. Emerging Infectious Diseases 3, 529-539.[CrossRef]
    [Google Scholar]
  20. Kawamura, N., Kohara, M., Abe, S., Komatsu, T., Tago, K., Arita, M. & Nomoto, A. ( 1989; ). Determinants in the 5′ noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype. Journal of Virology 63, 1302-1309.
    [Google Scholar]
  21. Matsuura, K., Hasegawa, S., Nakayama, T., Morita, O. & Uetake, H. ( 1984; ). Viral pollution of the rivers in Toyama City. Microbiology and Immunology 28, 575-588.[CrossRef]
    [Google Scholar]
  22. Matsuura, K., Ishikura, M., Yoshida, H., Nakayama, T., Hasegawa, S., Ando, S., Horie, H., Miyamura, T. & Kitamura, T. ( 2000; ). Assessment of poliovirus eradication in Japan: genomic analysis of polioviruses isolated from river water and sewage in Toyama Prefecture. Applied and Environmental Microbiology 66, 5087-5091.[CrossRef]
    [Google Scholar]
  23. Matyasova, I. & Koza, J. ( 1982; ). Properties of poliovirus strains isolated over the period 1969–1978 from the main municipal sewerage system of the city of Prague. Journal of Hygiene Epidemiology Microbiology and Immunology 26, 162-175.
    [Google Scholar]
  24. Matyasova, I. & Koza, J. ( 1985; ). Properties of poliovirus strains isolated from waste waters of nurseries in Prague in 1969–1982. Journal of Hygiene Epidemiology Microbiology and Immunology 29, 387-398.
    [Google Scholar]
  25. Metcalf, T. G., Mullin, B., Eckerson, D., Moulton, E. & Larkin, E. P. ( 1979; ). Bioaccumulation and depuration of enteroviruses by the soft-shelled clam, Mya arenaria. Applied and Environmental Microbiology 38, 275-282.
    [Google Scholar]
  26. Metcalf, T. G., Melnick, J. L. & Estes, M. K. ( 1995; ). Environmental virology: from detection of virus in sewage and water by isolation to identification by molecular biology – a trip of over 50 years. Annual Review of Microbiology 49, 461-487.[CrossRef]
    [Google Scholar]
  27. Pollard, S. R., Dunn, G., Cammack, N., Minor, P. D. & Almond, J. W. ( 1989; ). Nucleotide sequence of a neurovirulent variant of the type 2 oral poliovirus vaccine. Journal of Virology 63, 4949-4951.
    [Google Scholar]
  28. Pöyry, T., Stenvik, M. & Hovi, T. ( 1988; ). Viruses in sewage waters during and after a poliomyelitis outbreak and subsequent nationwide oral poliovirus vaccination campaign in Finland. Applied and Environmental Microbiology 54, 371-374.
    [Google Scholar]
  29. Rezapkin, G. V., Chumakov, K. M., Lu, Z., Ran, Y., Dragunsky, E. M. & Levenbook, I. S. ( 1994; ). Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine. Virology 202, 370-378.[CrossRef]
    [Google Scholar]
  30. Rezapkin, G. V., Fan, L., Asher, D. M., Fibi, M. R., Dragunsky, E. M. & Chumakov, K. M. ( 1999; ). Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype. Virology 258, 152-160.[CrossRef]
    [Google Scholar]
  31. Richards, G. P. ( 1999; ). Limitations of molecular biological techniques for assessing the virological safety of foods. Journal of Food Protection 62, 691-697.
    [Google Scholar]
  32. Shulman, L. M., Handsher, R., Yang, C. F., Yang, S. J., Manor, J., Vonsover, A., Grossman, Z., Pallansch, M., Mendelson, E. & Kew, O. M. ( 2000; ). Resolution of the pathways of poliovirus type 1 transmission during an outbreak. Journal of Clinical Microbiology 38, 945-952.
    [Google Scholar]
  33. Slater, P. E., Orenstein, W. A., Morag, A., Avni, A., Handsher, R., Green, M. S., Costin, C., Yarrow, A., Rishpon, S., Havkin, O., Ben-Zvi, T., Kew, O. M., Rey, M., Epstein, I., Swartz, T. A. & Melnick, J. L. ( 1990; ). Poliomyelitis outbreak in Israel in 1988: a report with two commentaries. Lancet 335, 1192-1195.[CrossRef]
    [Google Scholar]
  34. Taffs, R. E., Chumakov, K. M., Rezapkin, G. V., Lu, Z., Douthitt, M., Dragunsky, E. M. & Levenbook, I. S. ( 1995; ). Genetic stability and mutant selection in Sabin 2 strain of oral poliovirus vaccine grown under different cell culture conditions. Virology 209, 366-373.[CrossRef]
    [Google Scholar]
  35. Tambini, G., Andrus, J. K., Marques, E., Boshell, J., Pallansch, M., de Quadros, C. A. & Kew, O. ( 1993; ). Direct detection of wild poliovirus circulation by stool surveys of healthy children and analysis of community wastewater. Journal of Infectious Diseases 168, 1510-1514.[CrossRef]
    [Google Scholar]
  36. van der Avoort, H. G., Reimerink, J. H., Ras, A., Mulders, M. N. & van Loon, A. M. ( 1995; ). Isolation of epidemic poliovirus from sewage during the 1992–3 type 3 outbreak in The Netherlands. Epidemiology and Infection 114, 481-491.[CrossRef]
    [Google Scholar]
  37. Wood, D. J. & Macadam, A. J. ( 1997; ). Laboratory tests for live attenuated poliovirus vaccines. Biologicals 25, 3-15.[CrossRef]
    [Google Scholar]
  38. Yoshida, H., Li, J., Yoneyama, T., Yoshii, K., Shimizu, H., Nguyen, T. H., Toda, K., Nguyen, T. L., Phan, V. T., Miyamura, T. & Hagiwara, A. ( 1997; ). Two major strains of type 1 wild poliovirus circulating in Indochina. Journal of Infectious Diseases 175, 1233-1237.[CrossRef]
    [Google Scholar]
  39. Yoshida, H., Horie, H., Matsuura, K. & Miyamura, T. ( 2000; ). Characterization of vaccine-derived polioviruses isolated from sewage and river water in Japan. Lancet 356, 1461-1463.[CrossRef]
    [Google Scholar]
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