1887

Abstract

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-83-4-801
2002-04-01
2019-10-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/83/4/0830801a.html?itemId=/content/journal/jgv/10.1099/0022-1317-83-4-801&mimeType=html&fmt=ahah

References

  1. Borman, A. M., Quillent, C., Charneau, P., Kean, C. M. & Clavel, F. ( 1995; ). A highly defective HIV group O provirus: evidence for the role of local sequence determinants in hypermutation during negative strand DNA synthesis. Virology 208, 601-609.[CrossRef]
    [Google Scholar]
  2. Brown, T. C. & Jiricny, J. ( 1987; ). A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell 50, 945-950.[CrossRef]
    [Google Scholar]
  3. Charneau, P., Borman, A. M., Quillent, C., Guetard, D., Chamaret, S., Cohen, J., Remy, G., Montagnier, L. & Clavel, F. ( 1994; ). Isolation and envelope sequence of a highly divergent HIV-1 isolate: definition of a new HIV-1 group. Virology 205, 247-253.[CrossRef]
    [Google Scholar]
  4. Felsenstein, J. ( 1989; ). phylip: Phylogeny Inference Package (version 3.2). Cladistics 5, 164-166.
    [Google Scholar]
  5. Fitzgibbon, J. E., Mazar, S. & Dubin, D. T. ( 1993; ). A new type of G→A hypermutation affecting human immunodeficiency virus. AIDS Research and Human Retroviruses 9, 833-838.[CrossRef]
    [Google Scholar]
  6. Gojobori, T. & Yokoyama, S. ( 1987; ). Molecular evolutionary rates of oncogenes. Journal of Molecular Evolution 26, 148-156.[CrossRef]
    [Google Scholar]
  7. Günther, S., Sommer, G., Plikat, U., Wain-Hobson, S., Will, H. & Meyerhans, A. ( 1997; ). Naturally occurring hepatitis B virus subgenomes bearing the hallmarks of retroviral G→A hypermutation. Virology 235, 104-108.[CrossRef]
    [Google Scholar]
  8. Gürtler, L. G., Hauser, P. H., Eberle, J., von Brunn, A., Knapp, S., Zekeng, L., Tsague, J. M. & Kaptue, L. ( 1994; ). A new subtype of human immunodeficiency virus type 1 (MVP-5180) from Cameroon. Journal of Virology 68, 1581-1585.
    [Google Scholar]
  9. Janini, M., Rogers, M., Birx, D. R. & McCutchan, F. E. ( 2001; ). Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4+ T cells. Journal of Virology 75, 7973-7986.[CrossRef]
    [Google Scholar]
  10. Krawczak, M., Smith-Sorensen, B., Schmidtke, J., Kakkar, V. V., Cooper, D. N. & Hovig, E. ( 1995; ). Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and selection. Human Mutation 5, 48-57.[CrossRef]
    [Google Scholar]
  11. McCutchan, F. E., Artenstein, A. W., Sanders-Buell, E., Salminen, M. O., Carr, J. K., Mascola, J. R., Yu, X. F., Nelson, K. E., Khamboonruang, C., Schmitt, D., Kieny, M. P., McNeil, J. G. & Burke, D. S. ( 1996; ). Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E from Asia and Africa. Journal of Virology 6, 3331-3338.
    [Google Scholar]
  12. Martinez, M. A., Vartanian, J. P. & Wain-Hobson, S. ( 1994; ). Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations. Proceedings of the National Academy of Sciences, USA 91, 11787-11791.[CrossRef]
    [Google Scholar]
  13. Page, R. D. M. ( 1996; ). Treeview: an application to display phylogenetic trees on personal computers. Computer Applications in the Biosciences 12, 357-358.
    [Google Scholar]
  14. Richetti, M. & Buc, H. ( 1990; ). Reverse transcriptases and genomic variability: the accurancy of DNA replication is enzyme specific and sequence dependent. EMBO Journal 9, 1583-1593.
    [Google Scholar]
  15. Sala, M., Wain-Hobson, S. & Schaeffer, F. ( 1995; ). HIV-1 reverse transcriptase tG:T mispair formation on RNA and DNA templates with mismatched primers: a kinetic and thermodynamic study. EMBO Journal 14, 4622-4627.
    [Google Scholar]
  16. Thompson, J., Higgins, D. & Gibson, T. ( 1994; ). clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Research 22, 4673-4680.[CrossRef]
    [Google Scholar]
  17. Vanden Haesevelde, M., Decourt, J. L., De Leys, R. J., Vanderborght, B., van der Groen, G., van Heuverswijn, H. & Saman, E. ( 1994; ). Genomic cloning and complete sequence analysis of a highly divergent African human immunodeficiency virus isolate. Journal of Virology 68, 1586-1596.
    [Google Scholar]
  18. Vartanian, J. P., Meyerhans, A., Asjo, B. & Wain-Hobson, S. ( 1991; ). Selection, recombination, and G→A hypermutation of human immunodeficiency virus type 1 genomes. Journal of Virology 65, 1779-1788.
    [Google Scholar]
  19. Vartanian, J. P., Meyerhans, A., Sala, M. & Wain-Hobson, S. ( 1994; ). G→A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription. Proceedings of the National Academy of Sciences, USA 91, 3092-3096.[CrossRef]
    [Google Scholar]
  20. Vartanian, J. P., Plikat, U., Maheux, R., Guillemot, L., Meyerhans, A. & Wain-Hobson, S. ( 1997; ). HIV genetic variability is directed and restricted by DNA precursor availability. Journal of Molecular Biology 270, 139-151.[CrossRef]
    [Google Scholar]
  21. Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. ( 1985; ). Nucleotide sequence of the AIDS virus, LAV. Cell 40, 9-17.[CrossRef]
    [Google Scholar]
  22. Wain-Hobson, S., Sonigo, P., Guyader, M., Gazit, A. & Henry, M. ( 1995; ). Erratic G→A hypermutation within a complete caprine arthritis–encephalitis virus (CAEV) provirus. Virology 209, 297-303.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-83-4-801
Loading
/content/journal/jgv/10.1099/0022-1317-83-4-801
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error