1887

Abstract

The HLA DR13 allele has been associated with a self-limited course of hepatitis B virus infection, possibly through the induction of a more vigorous hepatitis B core antigen (HBcAg) and/or hepatitis B e antigen-specific CD4 T cell response. HBcAg-specific CD4 T cell responses were investigated in three HLA DR13-positive subjects with self-limited, acute hepatitis B. HBcAg-specific, short-term T cell lines derived from these three subjects showed a dominant recognition of HBcAg peptides spanning aa 1–20 (P1), 11–30 (P2), 41–60 (P5), 111–131 (P12) and 141–160 (P15). In order to characterize these epitopes in more detail, CD4 T cell clones and cell lines were generated using HBcAg. Surprisingly, 11 of 12 T cell clones examined recognized P15; one recognized P10 (aa 91–111). Of four T cell lines, two recognized P15 and two recognized P5. By peptide mapping, the minimal epitope of P15 was located to residues TVVRRRGRSP.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-83-12-3023
2002-12-01
2021-07-31
Loading full text...

Full text loading...

/deliver/fulltext/jgv/83/12/0833023a.html?itemId=/content/journal/jgv/10.1099/0022-1317-83-12-3023&mimeType=html&fmt=ahah

References

  1. Ahn S. H., Han K. H., Park J. Y., Lee C. K., Kang S. W., Chon C. Y., Kim Y. S., Park K., Kim D. K., Moon Y. M. 2000; Association between hepatitis B virus infection and HLA-DR type in Korea. Hepatology 31:1371–1373
    [Google Scholar]
  2. Almarri A., Batchelor J. R. 1994; HLA and hepatitis B infection. Lancet 344:1194–1195
    [Google Scholar]
  3. Black F. L., Pandey J. P., Capper R. A. 1986; Hepatitis B epidemiology and its relation to immunogenetic traits in South American Indians. American Journal of Epidemiology 123:336–343
    [Google Scholar]
  4. Cao T., Meuleman P., Desombere I., Sallberg M., Leroux-Roels G. 2001; In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4+ Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model. Journal of Virology 75:11449–11456
    [Google Scholar]
  5. Chen Y., Winchester R., Korber B., Gagliano J., Bryson Y., Hutto C., Martin N., McSherry G., Petru A., Wara D., Ammann A. 1997; Influence of HLA alleles on the rate of progression of vertically transmitted HIV infection in children: association of several HLA-DR13 alleles with long-term survivorship and the potential association of HLA-A*2301 with rapid progression to AIDS. Long-Term Survivor Study. Human Immunology 55:154–162
    [Google Scholar]
  6. Chisari F. V., Ferrari C. 1995; Hepatitis B virus immunopathogenesis. Annual Review of Immunology 13:29–60
    [Google Scholar]
  7. Couillin I., Pol S., Mancini M., Driss F., Brechot C., Tiollais P., Michel M. L. 1999; Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. Journal of Infectious Diseases 180:15–26
    [Google Scholar]
  8. Diepolder H. M., Jung M. C., Keller E., Schraut W., Gerlach J. T., Gruner N., Zachoval R., Hoffmann R. M., Schirren C. A., Scholz S., Pape G. R. 1998; A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B. Clinical and Experimental Immunology 113:244–251
    [Google Scholar]
  9. Ferrari C., Bertoletti A., Penna A., Cavalli A., Valli A., Missale G., Pilli M., Fowler P., Giuberti T., Chisari F. V., Fiaccadori F. 1991; Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. Journal of Clinical Investigation 88:214–222
    [Google Scholar]
  10. Forzani B., Actis G. C., Verme G., Amoroso A., Borelli L., Curtoni E. S., Rumi M. G., Picciotto A., Marinucci G., Freni M. A., Rizetto M. 1984; HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection. Hepatology 4:1107–1110
    [Google Scholar]
  11. Germain R. N. 1994; MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287–299
    [Google Scholar]
  12. Germain R. N., Margulies D. H. 1993; The biochemistry and cell biology of antigen processing and presentation. Annual Review of Immunology 11:403–450
    [Google Scholar]
  13. Guidotti L. G., Chisari F. V. 2001; Noncytolytic control of viral infections by the innate and adaptive immune response. Annual Review of Immunology 19:65–91
    [Google Scholar]
  14. Hill A. V., Allsopp C. E., Kwiatkowski D., Anstey N. M., Twumasi P., Rowe P. A., Bennett S., Brewster D., McMichael A. J., Greenwood B. M. 1991; Common west African HLA antigens are associated with protection from severe malaria. Nature 352:595–600
    [Google Scholar]
  15. Hohler T., Gerken G., Notghi A., Lubjuhn R., Taheri H., Protzer U., Lohr H. F., Schneider P. M., Meyer zum Buschenfelde K. H., Rittner C. 1997; HLA-DRB1*1301 and *1302 protect against chronic hepatitis B. Journal of Hepatology 26:503–507
    [Google Scholar]
  16. Ilan Y., Nagler A., Adler R., Tur-Kaspa R., Slavin S., Shouval D. 1993; Ablation of persistent hepatitis B by bone marrow transplantation from a hepatitis B-immune donor. Gastroenterology 104:1818–1821
    [Google Scholar]
  17. Jung M. C., Spengler U., Schraut W., Hoffmann R. M., Zachoval R., Eisenburg J., Eichenlaub D., Riethmüller G., Paumgartner G., Ziegler-Heitbrock H. W. and others 1992; Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B. Journal of Hepatology 13:310–317
    [Google Scholar]
  18. Jung M. C., Diepolder H. M., Spengler U., Wierenga E. A., Zachoval R., Hoffmann R. M., Eichenlaub D., Frosner G., Will H., Pape G. R. 1995; Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. Journal of Virology 69:3358–3368
    [Google Scholar]
  19. Kuzushita N., Hayashi N., Katayama K., Hiramatsu N., Yasumaru M., Murata H., Shimizu Y., Yamazaki T., Fushimi H., Kotoh K., Kasahara A., Fusamoto H., Kamada T. 1996; Increased frequency of HLA DR13 in hepatitis C virus carriers with persistently normal ALT levels. Journal of Medical Virology 48:1–7
    [Google Scholar]
  20. Kuzushita N., Hayashi N., Moribe T., Katayama K., Kanto T., Nakatani S., Kaneshige T., Tatsumi T., Ito A., Mochizuki K., Sasaki Y., Kasahara A., Hori M. 1998; Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus. Hepatology 27:240–244
    [Google Scholar]
  21. Lau G. K. K., Lok A. S., Liang R. H., Lai C. L., Chiu E. K., Lau Y. L., Lam S. K. 1997; Clearance of hepatitis B surface antigen after bone marrow transplantation: role of adoptive immunity transfer. Hepatology 25:1497–1501
    [Google Scholar]
  22. Lau G. K. K., Suri D., Liang R., Rigopoulou E. I., Thomas M. G., Mullerova I., Nanji A., Yuen S. T., Williams R., Naoumov N. V. 2002; Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen. Gastroenterology 122:614–624
    [Google Scholar]
  23. Lohr H. F., Weber W., Schlaak J., Goergen B., Meyer zum Buschenfelde K. H., Gerken G. 1995; Proliferative response of CD4+ T cells and hepatitis B virus clearance in chronic hepatitis with or without hepatitis B e-minus hepatitis B virus mutants. Hepatology 22:61–68
    [Google Scholar]
  24. Marinos G., Torre F., Chokshi S., Hussain M., Clarke B. E., Rowlands D. J., Eddleston A. L., Naoumov N. V., Williams R. 1995; Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. Hepatology 22:1040–1049
    [Google Scholar]
  25. Milich D. R. 1997; Immune response to the hepatitis B virus: infection, animal models, vaccination. Viral Hepatitis Reviews 3:63–103
    [Google Scholar]
  26. Penna A., Artini M., Cavalli A., Levrero M., Bertoletti A., Pilli M., Chisari F. V., Rehermann B., Del Prete G., Fiaccadori F., Ferrari C. 1996; Long-lasting memory T cell responses following self-limited acute hepatitis B. Journal of Clinical Investigation 98:1185–1194
    [Google Scholar]
  27. Penna A., Del Prete G., Cavalli A., Bertoletti A., D’Elios M. M., Sorrentino R., D’Amato M., Boni C., Pilli M., Fiaccadori F., Ferrari C. 1997; Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 25:1022–1027
    [Google Scholar]
  28. Pol S., Nalpas B., Driss F., Michel M. L., Tiollais P., Denis J., Brecho C. Multicenter study group. 2001; Efficacy and limitations of a specific immunotherapy in chronic hepatitis B. Journal of Hepatology 34:917–921
    [Google Scholar]
  29. Shouval D., Ilan Y. 1995; Transplantation of hepatitis B immune lymphocytes as means for adoptive transfer of immunity to hepatitis B virus. Journal of Hepatology 23:98–101
    [Google Scholar]
  30. Shouval D., Adler R., Ilan Y. 1993; Adoptive transfer of immunity to hepatitis B virus in mice by bone marrow transplantation from immune donors. Hepatology 17:955–959
    [Google Scholar]
  31. Thursz M. R., Kwiatkowski D., Allsopp C. E., Greenwood B. M., Thomas H. C., Hill A. V. 1995; Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. New England Journal of Medicine 332:1065–1069
    [Google Scholar]
  32. Zavaglia C., Bortolon C., Ferrioli G., Rho A., Mondazzi L., Bottelli R., Ghessi A., Gelosa F., Iamoni G., Ideo A. 1996; HLA typing in chronic type B, D and C hepatitis. Journal of Hepatology 24:658–665
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-83-12-3023
Loading
/content/journal/jgv/10.1099/0022-1317-83-12-3023
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error