@article{mbs:/content/journal/jgv/10.1099/0022-1317-83-11-2709, author = "Markine-Goriaynoff, Dominique and Hulhoven, Xavier and Cambiaso, César L. and Monteyne, Philippe and Briet, Thérèse and Gonzalez, Maria-Dolores and Coulie, Pierre and Coutelier, Jean-Paul", title = "Natural killer cell activation after infection with lactate dehydrogenase-elevating virus", journal= "Journal of General Virology", year = "2002", volume = "83", number = "11", pages = "2709-2716", doi = "https://doi.org/10.1099/0022-1317-83-11-2709", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-83-11-2709", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-γ), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced IFN-γ message expression and cytolysis, was observed. LDV triggered a large increase in serum IFN-γ levels. Because NK cells and IFN-γ may participate in the defence against virus infection, we analysed their possible role in the control of LDV titres with a new agglutination assay. Our results indicate that neither the activation of NK cells nor the IFN-γ secretion affect the early and rapid virus replication that follows LDV inoculation.", }