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Journal of General Virology header logo Journal of General Virology

Volume 83, Issue 11

Natural killer cell activation after infection with lactate dehydrogenase-elevating virus No Access

Abstract

Early after infection, lactate dehydrogenase-elevating virus (LDV) alters the immune system by polyclonally activating B lymphocytes, which leads to IgG2a-restricted hypergammaglobulinaemia, and by suppressing the secretion of Th2 cytokines. Considering that these alterations may involve cells of the innate immune system and cytokines such as interferon-gamma (IFN-γ), we analysed the effect of LDV on natural killer (NK) cells. Within a few days of infection, a strong and transient NK cell activation, characterized by enhanced γ message expression and cytolysis, was observed. LDV triggered a large increase in serum IFN-γ levels. Because NK cells and IFN-γ may participate in the defence against virus infection, we analysed their possible role in the control of LDV titres with a new agglutination assay. Our results indicate that neither the activation of NK cells nor the IFN-γ secretion affect the early and rapid virus replication that follows LDV inoculation.

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© Microbiology Society
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2002-11-01
2025-01-19
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Natural killer cell activation after infection with lactate dehydrogenase-elevating virus
J. Gen. Virol. 83, 2709 (2002); https://doi.org/10.1099/0022-1317-83-11-2709
/content/journal/jgv/10.1099/0022-1317-83-11-2709
/content/journal/jgv/10.1099/0022-1317-83-11-2709
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