@article{mbs:/content/journal/jgv/10.1099/0022-1317-83-10-2403, author = "Farkas, Szilvia L. and Benkő, Mária and Élő, Péter and Ursu, Krisztina and Dán, Ádám and Ahne, Winfried and Harrach, Balázs", title = "Genomic and phylogenetic analyses of an adenovirus isolated from a corn snake (Elaphe guttata) imply a common origin with members of the proposed new genus Atadenovirus", journal= "Journal of General Virology", year = "2002", volume = "83", number = "10", pages = "2403-2410", doi = "https://doi.org/10.1099/0022-1317-83-10-2403", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-83-10-2403", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Approximately 60% of the genome of an adenovirus isolated from a corn snake (Elaphe guttata) was cloned and sequenced. The results of homology searches showed that the genes of the corn snake adenovirus (SnAdV-1) were closest to their counterparts in members of the recently proposed new genus Atadenovirus. In phylogenetic analyses of the complete hexon and protease genes, SnAdV-1 indeed clustered together with the atadenoviruses. The characteristic features in the genome organization of SnAdV-1 included the presence of a gene homologous to that for protein p32K, the lack of structural proteins V and IX and the absence of homologues of the E1A and E3 regions. These characteristics are in accordance with the genus-defining markers of atadenoviruses. Comparison of the cleavage sites of the viral protease in core protein pVII also confirmed SnAdV-1 as a candidate member of the genus Atadenovirus. Thus, the hypothesis on the possible reptilian origin of atadenoviruses (Harrach, Acta Veterinaria Hungarica 48, 484–490, 2000) seems to be supported. However, the base composition of DNA sequence (>18 kb) determined from the SnAdV-1 genome showed an equilibrated GC content of 51%, which is unusual for an atadenovirus.", }