1887

Abstract

Genetic variation is the main evolutionary strategy adopted by RNA viruses and retroviruses. Evolution operates through competition between different individuals in the same environment, resulting in the imposition of the fittest variant. The process of competition could be affected by various factors, including the frequency of the different competing individuals. In order to investigate this aspect, individual virus populations derived from a human immunodeficiency virus type 1 isolate were studied at different competing proportions. The dynamics of variant imposition in each competition experiment permitted the detection of frequency-dependent selection (FDS); i.e. the imposition of variants is related to their biological fitness, which is also affected by the proportions at which they compete. The existence of FDS in different viruses with RNA genomes would indicate a general mechanism favouring genetic heterogeneity.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-83-1-103
2002-01-01
2019-10-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/83/1/0830103a.html?itemId=/content/journal/jgv/10.1099/0022-1317-83-1-103&mimeType=html&fmt=ahah

References

  1. Ayala, F. J. ( 1971; ). Competition between species: frequency dependence. Science 171, 820-824.[CrossRef]
    [Google Scholar]
  2. Ayala, F. J. & Campbell, C. A. ( 1974; ). Frequency-dependent selection. Annual Review of Ecology and Systematics 5, 115-138.[CrossRef]
    [Google Scholar]
  3. Coffin, J. M. ( 1995; ). HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.[CrossRef]
    [Google Scholar]
  4. de la Torre, J. C. & Holland, J. J. ( 1990; ). RNA virus quasispecies populations can suppress vastly superior mutant progeny. Journal of Virology 64, 6278-6281.
    [Google Scholar]
  5. Delwart, E. L., Sheppard, H. W., Walker, B. D., Goudsmit, J. & Mullins, J. I. ( 1994; ). Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays. Journal of Virology 68, 6672-6683.
    [Google Scholar]
  6. Domingo, E. & Holland, J. J. ( 1997; ). RNA virus mutations and fitness for survival. Annual Review of Microbiology 51, 151-178.[CrossRef]
    [Google Scholar]
  7. Domingo, E., Martı́nez-Salas, E., Sobrino, F., de la Torre, J. C., Portela, A., Ortin, J., López-Galı́ndez, C., Perez-Breña, P., Villanueva, N., Nájera, R., VandePol, S., Steinhauer, D., DePolo, N. & Holland, J. J. ( 1985; ). The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance – a review. Gene 40, 1-8.
    [Google Scholar]
  8. Domingo, E., Escarmis, C., Sevilla, N., Moya, A., Elena, S. F., Quer, J., Novella, I. S. & Holland, J. J. ( 1996; ). Basic concepts in RNA virus evolution. FASEB Journal 10, 859-864.
    [Google Scholar]
  9. Elena, S. F., Miralles, R. & Moya, A. ( 1997; ). Frequency-dependent selection in a mammalian RNA virus. Evolution 51, 984-987.[CrossRef]
    [Google Scholar]
  10. Goudsmit, J., de Ronde, A., de Rooij, E. & de Boer, R. ( 1997; ). Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215. Journal of Virology 71, 4479-4484.
    [Google Scholar]
  11. Harada, S., Koyanagi, Y. & Yamamoto, N. ( 1985; ). Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 229, 563-566.[CrossRef]
    [Google Scholar]
  12. Harrigan, P. R., Bloor, S. & Larder, B. A. ( 1998; ). Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro. Journal of Virology 72, 3773-3778.
    [Google Scholar]
  13. Holland, J. J., de la Torre, J. C., Clarke, D. K. & Duarte, E. ( 1991; ). Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses. Journal of Virology 65, 2960-2967.
    [Google Scholar]
  14. Holmes, E. C., Zhang, L. Q., Simmonds, P., Ludlam, C. A. & Leigh Brown, A. J. ( 1992; ). Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient. Proceedings of the National Academy of Sciences, USA 89, 4835-4839.[CrossRef]
    [Google Scholar]
  15. Moya, A., Elena, S. F., Bracho, A., Miralles, R. & Barrio, E. ( 2000; ). The evolution of RNA viruses: a population genetics view. Proceedings of the National Academy of Sciences, USA 97, 6967-6973.[CrossRef]
    [Google Scholar]
  16. Sanchez-Palomino, S., Rojas, J. M., Martinez, M. A., Fenyo, E. M., Najera, R., Domingo, E. & Lopez-Galindez, C. ( 1993; ). Dilute passage promotes expression of genetic and phenotypic variants of human immunodeficiency virus type 1 in cell culture. Journal of Virology 67, 2938-2943.
    [Google Scholar]
  17. Yuste, E., Sanchez-Palomino, S., Casado, C., Domingo, E. & Lopez-Galindez, C. ( 1999; ). Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events. Journal of Virology 73, 2745-2751.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-83-1-103
Loading
/content/journal/jgv/10.1099/0022-1317-83-1-103
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error