Evidence of Borna disease virus genome detection in French domestic animals and in foxes () Free

Abstract

Borna disease virus (BDV) is an enveloped, non-segmented negative-stranded RNA virus which belongs to the family. BDV is an aetiological agent of encephalitis in horses, sheep and several other vertebrate species. In order to extend our knowledge about the presence of BDV in France, a study based on BDV RNA detection by RT–nested-PCR was done with 196 animal tissues: 171 brain samples collected from different animal species (75 horses, 59 foxes, 31 cattle, 4 dogs, 1 sheep, 1 roe deer) and 25 horse blood samples. An RNA internal standard molecule was constructed and was co-amplified with the test template. This study reports the first detection of BDV RNA in France in 10 brain samples collected from horses, foxes and cattle, and from 14 horse blood samples. Detection of the BDV genome in the brains of six red foxes is the first evidence of BDV infection in this species.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-82-9-2199
2001-09-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/82/9/0822199a.html?itemId=/content/journal/jgv/10.1099/0022-1317-82-9-2199&mimeType=html&fmt=ahah

References

  1. Bahmani M. K., Nowrouzian I., Nakaya T., Nakamura Y., Hagiwara K., Takahashi H., Rad M. A., Ikuta K. 1996; Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. Virus Research 45:1–13
    [Google Scholar]
  2. Ballagi-Pordany A., Belak S. 1996; The use of mimics as internal standards to avoid false negatives in diagnostic PCR. Molecular and Cellular Probes 10:159–167
    [Google Scholar]
  3. Belak S., Ballagi-Pordany A. 1993; Experiences on the application of the polymerase chain reaction in a diagnostic laboratory. Molecular and Cellular Probes 7:241–248
    [Google Scholar]
  4. Berg A. L., Dorries R., Berg M. 1999; Borna disease virus infection in racing horses with behavioral and movement disorders. Archives of Virology 144:547–559
    [Google Scholar]
  5. Binz T., Lebelt J., Niemann H., Hagenau K. 1994; Sequence analysis of the p24 gene of Borna disease virus in naturally infected horse, donkey and sheep. Virus Research 34:281–289
    [Google Scholar]
  6. Bode L., Dürrwald R., Ludwig H. 1994; Borna virus infections in cattle associated with fatal neurological disease. Veterinary Record 135:283–284
    [Google Scholar]
  7. Boucher J. M., Barbillon E., Cliquet F. 1999; Borna disease: a possible emerging zoonosis. Veterinary Research 30:549–557
    [Google Scholar]
  8. Briese T., Schneemann A., Lewis A. J., Park Y. S., Kim S., Ludwig H., Lipkin W. I. 1994; Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, USA 91:4362–4366
    [Google Scholar]
  9. Caplazi P., Waldvogel A., Stitz L., Braun U., Ehrensperger F. 1994; Borna disease in naturally infected cattle. Journal of Comparative Pathology 111:65–72
    [Google Scholar]
  10. Cubitt B., de la Torre J. C. 1994; Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. Journal of Virology 68:1371–1381
    [Google Scholar]
  11. Degiorgis M.-P., Berg A.-L., Hard C., Segerstad A. F., Morner T., Johansson M., Berg M. 2000; Borna disease in a free ranging lynx ( Lynx lynx ). Journal of Clinical Microbiology 38:3087–3091
    [Google Scholar]
  12. de la Torre J. C. 1994; Molecular biology of Borna disease virus: prototype of a new group of animal viruses. Journal of Virology 68:7669–7675
    [Google Scholar]
  13. de la Torre J. C., Gonzalez-Dunia D., Cubitt B., Mallory M., Mueller-Lantzsch N., Grasser F. A., Hansen L. A., Masliah E. 1996; Detection of Borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. Virology 223:272–282
    [Google Scholar]
  14. Dürrwald R., Ludwig H. 1997; Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. Journal of Veterinary Medicine 44:147–184
    [Google Scholar]
  15. Galabru J., Saron M. F., Berg M., Berg A. L., Herzog S., Labie J., Zientara S. 2000; Borna disease virus antibodies in French horses. Veterinary Record 147:721–722
    [Google Scholar]
  16. Gonzalez-Dunia D. 1997; Borna disease virus and the brain. Brain Research Bulletin 44:647–664
    [Google Scholar]
  17. Hagiwara K., Nakaya T., Nakamura Y., Asahi S., Takahashi H., Ishihara C., Ikuta K. 1996; Borna disease virus RNA in peripheral blood mononuclear cells obtained from healthy dairy cattle. Medical Microbiology and Immunology 185:145–151
    [Google Scholar]
  18. Hagiwara K., Momiyama N., Taniyama H., Nakaya T., Tsunoda N., Ishihara C., Ikuta K. 1997; Demonstration of Borna disease virus (BDV) in specific regions of the brain from horses positive for serum antibodies to BDV but negative for BDV RNA in the blood and internal organs. Medical Microbiology and Immunology 186:19–24
    [Google Scholar]
  19. Hagiwara K., Kamitani W., Takamura S., Taniyama H., Nakaya T., Tanaka H., Kirisawa R., Iwai H., Ikuta K. 2000; Detection of Borna disease virus in a pregnant mare and her fetus. Veterinary Microbiology 72:207–216
    [Google Scholar]
  20. Herzog S., Pfeuffer I., Haberzettl K., Feldmann H., Frese K., Bechter K., Richt J. A. 1997; Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders. Archives of Virology 13:183–190
    [Google Scholar]
  21. Iwata Y., Takahashi K., Peng X., Fukuda K., Ohno K., Ogawa T., Gonda K., Mori N., Niwa S.-I., Shigeta S. 1998; Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. Journal of Virology 132:241–244
    [Google Scholar]
  22. Kao M., Hamir A. N., Rupprecht C. E., Fu Z. F., Shankar V., Koprowski H., Dietzschold B. 1993; Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Veterinary Record 132:241–244
    [Google Scholar]
  23. Legay V., Sailleau C., Dauphin G., Zientara S. 2000; Construction of an internal standard used in RT nested PCR for Borna disease virus RNA detection in biological samples. Veterinary Research 31:565–572
    [Google Scholar]
  24. Lipkin W. I., Travis G. H., Carbone K. M., Wilson M. C. 1990; Isolation and characterization of Borna disease agent cDNA clones. Proceedings of the National Academy of Sciences, USA 87:4184–4188
    [Google Scholar]
  25. Ludwig H., Bode L. 2000; Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Revue Scientifique et Technique Office International des Epizooties 19:259–288
    [Google Scholar]
  26. Ludwig H., Bode L., Gosztonyi G. 1988; Borna disease: a persistent virus infection of the central nervous system. Progress in Medical Virology 35:107–151
    [Google Scholar]
  27. Lundgren A.-L., Zimmermann W., Bode L., Czech G., Gosztonyi G., Lindberg R., Ludwig H. 1995; Staggering disease in cats: isolation and characterization of the feline Borna disease virus. Journal of General Virology 76:2215–2222
    [Google Scholar]
  28. Malkinson M., Weisman Y., Perl S., Ashash E. 1995; A Borna-like disease of ostriches in Israel. Current Topics in Microbiology and Immunology 190:31–38
    [Google Scholar]
  29. Matthias D. 1954; Der Nachweis von latent infizierten Pferden, Schafen und Rindern und deren Bedeutung als Virusreservoir bei der Bornaschen Krankheit. Archiv fuer experimentelle Veterinaermedizin 8:506–511
    [Google Scholar]
  30. Metzler A., Ehrensperger F., Wyler R. 1978; Natürliche Bornavirusinfektion beim Kaninchen. Zentralblatt fuer Veterinaermedizin Reihe B 25:161–164
    [Google Scholar]
  31. Metzler A., Ehrensperger F., Danner K. 1979; Bornavirus-Infektion bei Schafen: Verlaufsuntersuchungen nach spontaner Infektion, unter besonderer Berücksichtigung der Antikörperkinetik im Serum und Liquor cerebrospinalis. Schweizer Archiv fuer Tierheilkunde 121:37–48
    [Google Scholar]
  32. Nakamura Y., Kishi M., Nakaya T., Asahi S., Tanaka H., Sentsui H., Ikeda K., Ikuta K. 1995; Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. Vaccine 13:1076–1079
    [Google Scholar]
  33. Nakamura Y., Takahashi H., Shoya Y., Nakaya T., Watanabe M., Tomonaga K., Iwahashi K., Ameno K., Nomiyama N., Taniyama H., Sata T., Kurata T., de la Torre J. C., Ikuta K. 2000; Isolation of Borna disease virus from human brain tissue. Journal of Virology 74:4601–4611
    [Google Scholar]
  34. Nicolau S., Galloway I. A. 1928; Borna disease and enzootic encephalomyelitis of sheep and cattle. In Medical Research Council Special Reports Series vol 121 London: His Majesty’s Stationery Office;
    [Google Scholar]
  35. Nowotny N., Kolodziejek J. 2000; Human bornaviruses and laboratory strains. Lancet 355:1462–1463
    [Google Scholar]
  36. Richt A. J., Van de Woude S., Zink M. C., Clements J. E., Herzog S., Stitz L. 1992; Infection with Borna disease virus: molecular and immunobiological characterization of the agent. Clinical Infectious Diseases 14:1240–1250
    [Google Scholar]
  37. Richt A. J., Pfeuffer I., Christ M., Frese K., Bechter K., Herzog S. 1997; Borna disease virus infection in animals and humans. Emerging Infectious Diseases 3:343–352
    [Google Scholar]
  38. Rott R., Becht H. 1995; Natural and experimental Borna disease in animals. Current Topics in Microbiology and Immunology 190:17–30
    [Google Scholar]
  39. Sailleau C., Moulay S., Crucière C., Zientara S. 1997; Detection of African horse sickness virus in the blood of experimentally infected horses: comparison of virus isolation and a PCR assay. Research in Veterinary Science. 62229–232
  40. Sailleau C., Hamblin C., Paweska J. T., Zientara S. 2000; Identification and differentiation of the nine African horse sickness virus serotypes by RT–PCR amplification of the serotype-specific genome segment 2. Journal of General Virology 81:831–837
    [Google Scholar]
  41. Sauder C., de la Torre J. C. 1998; Sensitivity and reproducibility of RT–PCR to detect Borna disease virus (BDV) RNA in blood: implications for BDV epidemiology. Journal of Virological Methods 71:229–245
    [Google Scholar]
  42. Sauder C., Muller A., Cubitt B., Mayer J., Steinmetz J., Trabert W., Ziegler B., Wanke K., Mueller-Lantzsch N., de la Torre J. C., Grasser F. A. 1996; Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. Journal of Virology 70:7713–7724
    [Google Scholar]
  43. Schneider P. A., Briese T., Zimmermann W., Ludwig H., Lipkin W. I. 1994; Sequence conservation in field and experimental isolates of Borna disease virus. Journal of Virology 68:63–68
    [Google Scholar]
  44. Sorg I., Metzler A. 1995; Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. Journal of Clinical Microbiology 33:821–823
    [Google Scholar]
  45. Staeheli P., Sauder C., Hausmann J., Ehrensperger F., Schwemmle M. 2000; Epidemiology of Borna disease virus. Journal of General Virology 81:2123–2135
    [Google Scholar]
  46. Stitz L., Krey H., Ludwig H. 1980; Borna disease in rhesus monkeys as a model for uveo-cerebral symptoms. Journal of Veterinary Medicine 6:333–340
    [Google Scholar]
  47. Vahlenkamp T., Enbergs H., Müller H. 2000; Experimental and natural Borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Veterinary Microbiology 76:229–244
    [Google Scholar]
  48. Van de Woude S., Richt J. A., Zink M. C., Rott R., Narayan O., Clements J. E. 1990; A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250:1278–1281
    [Google Scholar]
  49. Weissenböck H., Nowotny N., Caplazi P., Kolodziejek J., Ehrensperger F. 1998; Borna disease in a dog with lethal meningoencephalitis. Journal of Clinical Microbiology 36:2127–2130
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-82-9-2199
Loading
/content/journal/jgv/10.1099/0022-1317-82-9-2199
Loading

Data & Media loading...

Most cited Most Cited RSS feed