1887

Abstract

Borna disease virus (BDV) is an enveloped, non-segmented negative-stranded RNA virus which belongs to the family. BDV is an aetiological agent of encephalitis in horses, sheep and several other vertebrate species. In order to extend our knowledge about the presence of BDV in France, a study based on BDV RNA detection by RT–nested-PCR was done with 196 animal tissues: 171 brain samples collected from different animal species (75 horses, 59 foxes, 31 cattle, 4 dogs, 1 sheep, 1 roe deer) and 25 horse blood samples. An RNA internal standard molecule was constructed and was co-amplified with the test template. This study reports the first detection of BDV RNA in France in 10 brain samples collected from horses, foxes and cattle, and from 14 horse blood samples. Detection of the BDV genome in the brains of six red foxes is the first evidence of BDV infection in this species.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-82-9-2199
2001-09-01
2020-04-03
Loading full text...

Full text loading...

/deliver/fulltext/jgv/82/9/0822199a.html?itemId=/content/journal/jgv/10.1099/0022-1317-82-9-2199&mimeType=html&fmt=ahah

References

  1. Bahmani M. K., Nowrouzian I., Nakaya T., Nakamura Y., Hagiwara K., Takahashi H., Rad M. A., Ikuta K.. 1996; Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. Virus Research45:1–13
    [Google Scholar]
  2. Ballagi-Pordany A., Belak S.. 1996; The use of mimics as internal standards to avoid false negatives in diagnostic PCR. Molecular and Cellular Probes10:159–167
    [Google Scholar]
  3. Belak S., Ballagi-Pordany A.. 1993; Experiences on the application of the polymerase chain reaction in a diagnostic laboratory. Molecular and Cellular Probes7:241–248
    [Google Scholar]
  4. Berg A. L., Dorries R., Berg M.. 1999; Borna disease virus infection in racing horses with behavioral and movement disorders. Archives of Virology144:547–559
    [Google Scholar]
  5. Binz T., Lebelt J., Niemann H., Hagenau K.. 1994; Sequence analysis of the p24 gene of Borna disease virus in naturally infected horse, donkey and sheep. Virus Research34:281–289
    [Google Scholar]
  6. Bode L., Dürrwald R., Ludwig H.. 1994; Borna virus infections in cattle associated with fatal neurological disease. Veterinary Record135:283–284
    [Google Scholar]
  7. Boucher J. M., Barbillon E., Cliquet F.. 1999; Borna disease: a possible emerging zoonosis. Veterinary Research30:549–557
    [Google Scholar]
  8. Briese T., Schneemann A., Lewis A. J., Park Y. S., Kim S., Ludwig H., Lipkin W. I.. 1994; Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, USA91:4362–4366
    [Google Scholar]
  9. Caplazi P., Waldvogel A., Stitz L., Braun U., Ehrensperger F.. 1994; Borna disease in naturally infected cattle. Journal of Comparative Pathology111:65–72
    [Google Scholar]
  10. Cubitt B., de la Torre J. C.. 1994; Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. Journal of Virology68:1371–1381
    [Google Scholar]
  11. Degiorgis M.-P., Berg A.-L., Hard C., Segerstad A. F., Morner T., Johansson M., Berg M.. 2000; Borna disease in a free ranging lynx ( Lynx lynx ). Journal of Clinical Microbiology38:3087–3091
    [Google Scholar]
  12. de la Torre J. C.. 1994; Molecular biology of Borna disease virus: prototype of a new group of animal viruses. Journal of Virology68:7669–7675
    [Google Scholar]
  13. de la Torre J. C., Gonzalez-Dunia D., Cubitt B., Mallory M., Mueller-Lantzsch N., Grasser F. A., Hansen L. A., Masliah E.. 1996; Detection of Borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. Virology223:272–282
    [Google Scholar]
  14. Dürrwald R., Ludwig H.. 1997; Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. Journal of Veterinary Medicine44:147–184
    [Google Scholar]
  15. Galabru J., Saron M. F., Berg M., Berg A. L., Herzog S., Labie J., Zientara S.. 2000; Borna disease virus antibodies in French horses. Veterinary Record147:721–722
    [Google Scholar]
  16. Gonzalez-Dunia D.. 1997; Borna disease virus and the brain. Brain Research Bulletin44:647–664
    [Google Scholar]
  17. Hagiwara K., Nakaya T., Nakamura Y., Asahi S., Takahashi H., Ishihara C., Ikuta K.. 1996; Borna disease virus RNA in peripheral blood mononuclear cells obtained from healthy dairy cattle. Medical Microbiology and Immunology185:145–151
    [Google Scholar]
  18. Hagiwara K., Momiyama N., Taniyama H., Nakaya T., Tsunoda N., Ishihara C., Ikuta K.. 1997; Demonstration of Borna disease virus (BDV) in specific regions of the brain from horses positive for serum antibodies to BDV but negative for BDV RNA in the blood and internal organs. Medical Microbiology and Immunology186:19–24
    [Google Scholar]
  19. Hagiwara K., Kamitani W., Takamura S., Taniyama H., Nakaya T., Tanaka H., Kirisawa R., Iwai H., Ikuta K.. 2000; Detection of Borna disease virus in a pregnant mare and her fetus. Veterinary Microbiology72:207–216
    [Google Scholar]
  20. Herzog S., Pfeuffer I., Haberzettl K., Feldmann H., Frese K., Bechter K., Richt J. A.. 1997; Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders. Archives of Virology13:183–190
    [Google Scholar]
  21. Iwata Y., Takahashi K., Peng X., Fukuda K., Ohno K., Ogawa T., Gonda K., Mori N., Niwa S.-I., Shigeta S.. 1998; Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. Journal of Virology132:241–244
    [Google Scholar]
  22. Kao M., Hamir A. N., Rupprecht C. E., Fu Z. F., Shankar V., Koprowski H., Dietzschold B.. 1993; Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Veterinary Record132:241–244
    [Google Scholar]
  23. Legay V., Sailleau C., Dauphin G., Zientara S.. 2000; Construction of an internal standard used in RT nested PCR for Borna disease virus RNA detection in biological samples. Veterinary Research31:565–572
    [Google Scholar]
  24. Lipkin W. I., Travis G. H., Carbone K. M., Wilson M. C.. 1990; Isolation and characterization of Borna disease agent cDNA clones. Proceedings of the National Academy of Sciences, USA87:4184–4188
    [Google Scholar]
  25. Ludwig H., Bode L.. 2000; Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Revue Scientifique et Technique Office International des Epizooties19:259–288
    [Google Scholar]
  26. Ludwig H., Bode L., Gosztonyi G.. 1988; Borna disease: a persistent virus infection of the central nervous system. Progress in Medical Virology35:107–151
    [Google Scholar]
  27. Lundgren A.-L., Zimmermann W., Bode L., Czech G., Gosztonyi G., Lindberg R., Ludwig H.. 1995; Staggering disease in cats: isolation and characterization of the feline Borna disease virus. Journal of General Virology76:2215–2222
    [Google Scholar]
  28. Malkinson M., Weisman Y., Perl S., Ashash E.. 1995; A Borna-like disease of ostriches in Israel. Current Topics in Microbiology and Immunology190:31–38
    [Google Scholar]
  29. Matthias D.. 1954; Der Nachweis von latent infizierten Pferden, Schafen und Rindern und deren Bedeutung als Virusreservoir bei der Bornaschen Krankheit. Archiv fuer experimentelle Veterinaermedizin8:506–511
    [Google Scholar]
  30. Metzler A., Ehrensperger F., Wyler R.. 1978; Natürliche Bornavirusinfektion beim Kaninchen. Zentralblatt fuer Veterinaermedizin Reihe B25:161–164
    [Google Scholar]
  31. Metzler A., Ehrensperger F., Danner K.. 1979; Bornavirus-Infektion bei Schafen: Verlaufsuntersuchungen nach spontaner Infektion, unter besonderer Berücksichtigung der Antikörperkinetik im Serum und Liquor cerebrospinalis. Schweizer Archiv fuer Tierheilkunde121:37–48
    [Google Scholar]
  32. Nakamura Y., Kishi M., Nakaya T., Asahi S., Tanaka H., Sentsui H., Ikeda K., Ikuta K.. 1995; Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. Vaccine13:1076–1079
    [Google Scholar]
  33. Nakamura Y., Takahashi H., Shoya Y., Nakaya T., Watanabe M., Tomonaga K., Iwahashi K., Ameno K., Nomiyama N., Taniyama H., Sata T., Kurata T., de la Torre J. C., Ikuta K.. 2000; Isolation of Borna disease virus from human brain tissue. Journal of Virology74:4601–4611
    [Google Scholar]
  34. Nicolau S., Galloway I. A.. 1928; Borna disease and enzootic encephalomyelitis of sheep and cattle. In Medical Research Council Special Reports Series vol 121 London: His Majesty’s Stationery Office;
    [Google Scholar]
  35. Nowotny N., Kolodziejek J.. 2000; Human bornaviruses and laboratory strains. Lancet355:1462–1463
    [Google Scholar]
  36. Richt A. J., Van de Woude S., Zink M. C., Clements J. E., Herzog S., Stitz L.. 1992; Infection with Borna disease virus: molecular and immunobiological characterization of the agent. Clinical Infectious Diseases14:1240–1250
    [Google Scholar]
  37. Richt A. J., Pfeuffer I., Christ M., Frese K., Bechter K., Herzog S.. 1997; Borna disease virus infection in animals and humans. Emerging Infectious Diseases3:343–352
    [Google Scholar]
  38. Rott R., Becht H.. 1995; Natural and experimental Borna disease in animals. Current Topics in Microbiology and Immunology190:17–30
    [Google Scholar]
  39. Sailleau C., Moulay S., Crucière C., Zientara S.. 1997; Detection of African horse sickness virus in the blood of experimentally infected horses: comparison of virus isolation and a PCR assay . Research in Veterinary Science. 62229–232
  40. Sailleau C., Hamblin C., Paweska J. T., Zientara S.. 2000; Identification and differentiation of the nine African horse sickness virus serotypes by RT–PCR amplification of the serotype-specific genome segment 2. Journal of General Virology81:831–837
    [Google Scholar]
  41. Sauder C., de la Torre J. C.. 1998; Sensitivity and reproducibility of RT–PCR to detect Borna disease virus (BDV) RNA in blood: implications for BDV epidemiology. Journal of Virological Methods71:229–245
    [Google Scholar]
  42. Sauder C., Muller A., Cubitt B., Mayer J., Steinmetz J., Trabert W., Ziegler B., Wanke K., Mueller-Lantzsch N., de la Torre J. C., Grasser F. A.. 1996; Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. Journal of Virology70:7713–7724
    [Google Scholar]
  43. Schneider P. A., Briese T., Zimmermann W., Ludwig H., Lipkin W. I.. 1994; Sequence conservation in field and experimental isolates of Borna disease virus. Journal of Virology68:63–68
    [Google Scholar]
  44. Sorg I., Metzler A.. 1995; Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. Journal of Clinical Microbiology33:821–823
    [Google Scholar]
  45. Staeheli P., Sauder C., Hausmann J., Ehrensperger F., Schwemmle M.. 2000; Epidemiology of Borna disease virus . Journal of General Virology81:2123–2135
    [Google Scholar]
  46. Stitz L., Krey H., Ludwig H.. 1980; Borna disease in rhesus monkeys as a model for uveo-cerebral symptoms. Journal of Veterinary Medicine6:333–340
    [Google Scholar]
  47. Vahlenkamp T., Enbergs H., Müller H.. 2000; Experimental and natural Borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Veterinary Microbiology76:229–244
    [Google Scholar]
  48. Van de Woude S., Richt J. A., Zink M. C., Rott R., Narayan O., Clements J. E.. 1990; A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science250:1278–1281
    [Google Scholar]
  49. Weissenböck H., Nowotny N., Caplazi P., Kolodziejek J., Ehrensperger F.. 1998; Borna disease in a dog with lethal meningoencephalitis. Journal of Clinical Microbiology36:2127–2130
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-82-9-2199
Loading
/content/journal/jgv/10.1099/0022-1317-82-9-2199
Loading

Data & Media loading...

Most cited this month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error