RT Journal Article SR Electronic(1) A1 Evlashev, Alexey A1 Valentin, Hélène A1 Rivailler, Pierre A1 Azocar, Olga A1 Rabourdin-Combe, Chantal A1 Horvat, BrankaYR 2001 T1 Differential permissivity to measles virus infection of human and CD46-transgenic murine lymphocytes JF Journal of General Virology, VO 82 IS 9 SP 2125 OP 2129 DO https://doi.org/10.1099/0022-1317-82-9-2125 PB Microbiology Society, SN 1465-2099, AB Analysis of measles virus (MV) pathogenesis requires the development of an adequate small animal model of MV infection. In this study, permissivity to MV infection was compared in human and transgenic murine T lymphocytes, expressing different levels of the human MV receptor, CD46. Whereas MV binding and entry correlated with CD46 expression, higher levels of MV replication were always observed in human T lymphocytes. This suggests the existence of intracellular factors, acting posterior to virus entry, that could limit MV replication in murine lymphocytes and should be considered when creating new animal models of MV infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-9-2125