1887

Abstract

Analysis of measles virus (MV) pathogenesis requires the development of an adequate small animal model of MV infection. In this study, permissivity to MV infection was compared in human and transgenic murine T lymphocytes, expressing different levels of the human MV receptor, CD46. Whereas MV binding and entry correlated with CD46 expression, higher levels of MV replication were always observed in human T lymphocytes. This suggests the existence of intracellular factors, acting posterior to virus entry, that could limit MV replication in murine lymphocytes and should be considered when creating new animal models of MV infection.

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/content/journal/jgv/10.1099/0022-1317-82-9-2125
2001-09-01
2024-12-13
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References

  1. Blixenkrone-Moller M., Bernard A., Bencsik A., Sixt N., Diamond L. E., Logan J. S., Wild T. F. 1998; Role of CD46 in measles virus infection in CD46 transgenic mice. Virology 249:238–248
    [Google Scholar]
  2. Browning J., Horner J. W., Pettoello-Mantovani M., Raker C., Yurasov S., DePinho R. A., Goldstein H. 1997; Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection. Proceedings of the National Academy of Sciences, USA 94:14637–14641
    [Google Scholar]
  3. Dorig R. E., Marcil A., Chopra A., Richardson C. D. 1993; The human CD46 molecule is a receptor for measles virus (Edmonston strain. Cell 75:295–305
    [Google Scholar]
  4. Evlashev A., Moyse E., Valentin H., Azocar O., Trescol-Biemont M. C., Marie J. C., Rabourdin-Combe C., Horvat B. 2000; Productive measles virus brain infection and apoptosis in CD46 transgenic mice. Journal of Virology 74:1373–1382
    [Google Scholar]
  5. Horvat B., Rivailler P., Varior-Krishnan G., Cardoso A., Gerlier D., Rabourdin-Combe C. 1996; Transgenic mice expressing human measles virus (MV) receptor CD46 provide cells exhibiting different permissivities to MV infection. Journal of Virology 70:6673–6681
    [Google Scholar]
  6. Moyer S. A., Baker S. C., Horikami S. M. 1990; Host cell proteins required for measles virus reproduction. Journal of General Virology 71:775–783
    [Google Scholar]
  7. Mrkic B., Pavlovic J., Rulicke T., Volpe P., Buchholz C. J., Hourcade D., Atkinson J. P., Aguzzi A., Cattaneo R. 1998; Measles virus spread and pathogenesis in genetically modified mice. Journal of Virology 72:7420–7427
    [Google Scholar]
  8. Murray C. J., Lopez A. D. 1997; Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349:1269–1276
    [Google Scholar]
  9. Naniche D., Wild T. F., Rabourdin-Combe C., Gerlier D. 1992; A monoclonal antibody recognizes a human cell surface glycoprotein involved in measles virus binding. Journal of General Virology 73:2617–2624
    [Google Scholar]
  10. Naniche D., Varior-Krishnan G., Cervoni F., Wild T. F., Rossi B., Rabourdin-Combe C., Gerlier D. 1993; Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. Journal of Virology 67:6025–6032
    [Google Scholar]
  11. Niewiesk S., Schneider-Schaulies J., Ohnimus H., Jassoy C., Schneider-Schaulies S., Diamond L., Logan J. S., ter Meulen V. 1997; CD46 expression does not overcome the intracellular block of measles virus replication in transgenic rats. Journal of Virology 71:7969–7973
    [Google Scholar]
  12. Oldstone M. B., Lewicki H., Thomas D., Tishon A., Dales S., Patterson J., Manchester M., Homann D., Naniche D., Holz A. 1999; Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease. Cell 98:629–640
    [Google Scholar]
  13. Rall G. F., Manchester M., Daniels L. R., Callahan E. M., Belman A. R., Oldstone M. B. 1997; A transgenic mouse model for measles virus infection of the brain. Proceedings of the National Academy of Sciences, USA 94:4659–4663
    [Google Scholar]
  14. Tatsuo H., Ono N., Tanaka K., Yanagi Y. 2000; SLAM (CDw150) is a cellular receptor for measles virus. Nature 406:893–897
    [Google Scholar]
  15. Thorley B. R., Milland J., Christiansen D., Lanteri M. B., McInnes B., Moeller I., Rivailler P., Horvat B., Rabourdin-Combe C., Gerlier D., McKenzie I. F., Loveland B. E. 1997; Transgenic expression of a CD46 (membrane cofactor protein) minigene: studies of xenotransplantation and measles virus infection. European Journal of Immunology 27:726–734
    [Google Scholar]
  16. Vincent S., Spehner D., Manié S., Delorme R., Drillien R., Gerlier D. 1999; Inefficient measles virus budding in murine L.CD46 fibroblasts. Virology 265:185–195
    [Google Scholar]
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