RT Journal Article SR Electronic(1) A1 Kabrane-Lazizi, Yamina A1 Zhang, Mingdong A1 Purcell, Robert H. A1 Miller, Kirk D. A1 Davey, Richard T. A1 Emerson, Suzanne U.YR 2001 T1 Acute hepatitis caused by a novel strain of hepatitis E virus most closely related to United States strains JF Journal of General Virology, VO 82 IS 7 SP 1687 OP 1693 DO https://doi.org/10.1099/0022-1317-82-7-1687 PB Microbiology Society, SN 1465-2099, AB A unique hepatitis E virus (HEV) strain was identified as the aetiological agent of acute hepatitis in a United States (US) patient who had recently returned from vacation in Thailand, a country in which HEV is endemic. Sequence comparison showed that this HEV strain was most similar, but not identical, to the swine and human HEV strains recovered in the US. Phylogenetic analysis revealed that this new HEV isolate was closer to genotype 3 strains than to the genotype 1 strains common in Asia. The fact that this HEV was closely related to strains recovered in countries where HEV is not endemic and was highly divergent from Asian HEV strains raises the questions of where the patient’s infection was acquired and of whether strains are geographically as localized as once thought., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-7-1687