RT Journal Article SR Electronic(1) A1 Cheynier, Rémi A1 Kils-Hütten, Laurens A1 Meyerhans, Andreas A1 Wain-Hobson, SimonYR 2001 T1 Insertion/deletion frequencies match those of point mutations in the hypervariable regions of the simian immunodeficiency virus surface envelope gene JF Journal of General Virology, VO 82 IS 7 SP 1613 OP 1619 DO https://doi.org/10.1099/0022-1317-82-7-1613 PB Microbiology Society, SN 1465-2099, AB A method for encoding insertions and deletions (indels) has been developed and adapted to the SplitsTree program. Following phylogenetic reconstruction, the relative frequencies of indels were estimated for a large number of in vivo sequence sets corresponding to the env V1 hypervariable region of the simian immunodeficiency virus SIVmac251. The method allowed recovery of many point mutations hitherto lost due to gap stripping. Deletions were as frequent as transversions and were 4- to 8-fold more frequent than insertions, invariably duplications. The high proportion of deletions among mutation events suggests that lentivirus vectors may readily delete parts of their cargo., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-7-1613