1887

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Volume 82, Issue 7

Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys Free

Abstract

In this study we compared the efficacy of live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine alone versus boosting with live non-pathogenic HIV-2 following priming with ALVAC HIV-2 (recombinant canarypox virus expressing HIV-2 , and ). Six monkeys were first inoculated intravenously with live HIV-2 and 7 to 10 months later were challenged intrarectally with 10 MID of cell-free simian immunodeficiency virus (SIV) strain SIVsm. One monkey was completely protected against SIV infection and all five monkeys that became SIV-infected showed a lower virus replication and an initial lower virus load as compared with a parallel group of six control animals. In another experiment five monkeys were immunized either three times with ALVAC HIV-2 alone or twice with ALVAC HIV-2 and once with purified native HIV-2 gp125. The monkeys were then challenged with HIV-2 given intravenously and finally with pathogenic SIVsm given intrarectally. After challenge with SIVsm, three of five monkeys were completely protected against SIVsm infection whereas the remaining two macaques became SIV-infected but with limited virus replication. In conclusion, vaccination with an ALVAC HIV-2 vaccine followed by exposure to live HIV-2 could induce cross-protection against mucosal infection with SIVsm and seemed to be more efficient than immunization with a live HIV-2 vaccine only.

  • Received:
  • Accepted:
  • Published Online:
© Microbiology Society
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2001-07-01
2024-04-25
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References

  1. Abimuku A. G., Robert-Guroff M., Benson J., Tartaglia J., Paoletti E., Gallo R. C., Markham P. D., Franchini G. 1997; Long-term survival of SIVmac251-infected macaques previously immunised with NYVAC-SIV vaccines. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 15:78–85
     [Google Scholar]
  2. Ahmed R. K. S., Nilsson C., Wang Y., Lehner T., Biberfeld G., Thorstensson R. 1999; β-Chemokine production in macaques vaccinated with live attenuated virus correlates with protection against simian immunodeficiency virus (SIVsm) challenge. Journal of General Virology 80:1569–1574
     [Google Scholar]
  3. Ahmed R. K. S., Nilsson C., Biberfeld G., Thorstensson R. 2001; Role of CD8+ cell-produced anti-viral factors in protective immunity in HIV-2-exposed but seronegative macaques resistant to intrarectal SIVsm challenge. Scandinavian Journal of Immunology 53:245–253
     [Google Scholar]
  4. Almond N. M., Heeney J. L. 1998; AIDS vaccine development in primate models. AIDS 12:133–140
     [Google Scholar]
  5. Almond N., Kent K., Cranage M., Rud E., Clarke B., Stott E. J. 1995; Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345:1342–1344
     [Google Scholar]
  6. Andersson S., Mäkitalo B., Thorstensson R., Franchini G., Tartaglia J., Limbach K., Paoletti E., Putkonen P., Biberfeld G. 1996; Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys. Journal of Infectious Diseases 174:977–985
     [Google Scholar]
  7. Benson J., Chougnet C., Robert-Guroff M., Montefiori D., Markham P., Shearer G., Gallo R. C., Cranage M., Paoletti E., Limbach K., Venzon D., Tartaglia J., Franchini G. 1998; Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIVmac251: dependence on route of challenge exposure. Journal of Virology 72:4170–4182
     [Google Scholar]
  8. Benveniste R. E., Morton W. R., Clark E. A., Tsai C. C., Ochs H. D., Ward J. M., Kuller L., Knott W. B., Hill R. W., Gale M. J. and others 1988; Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. Journal of Virology 62:2091–2101
     [Google Scholar]
  9. Biberfeld P., Öst Å., Porwit A., Sandstedt B., Pallesen G., Böttiger B., Morfeldt-Månsson L., Biberfeld G. 1986; Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 95:47–65
     [Google Scholar]
  10. Bogers W. M., Niphuis H., ten Haaft P., Laman J. D., Koornstra W., Heeney J. L. 1995; Protection from HIV-1 envelope-bearing chimeric simian immunodeficiency virus (SHIV) in rhesus macaques infected with attenuated SIV: consequences of challenge. AIDS 9:13–18
     [Google Scholar]
  11. Castaños-Vélez E., Heiden T., Ekman M., Lawrence J., Biberfeld G., Biberfeld P. 1999; Proliferation and apoptosis-related gene expression in experimental acquired immunodeficiency syndrome-related simian lymphoma. Blood 93:1364–1371
     [Google Scholar]
  12. Cranage M. P., Whatmore A. M., Sharpe S. A., Cook N., Polyanskaya N., Leech S., Smith J. D., Rud E. W., Dennis M. J., Hall G. A. 1997; Macaques infected with live attenuated SIVmac are protected against superinfection via the rectal mucosa. Virology 229:143–154
     [Google Scholar]
  13. Daniel M. D., Letvin N. L., King N. W., Kannagi M., Sehgal P. K., Hunt R. D., Kanki P. J., Essex M., Desrosier R. C. 1985; Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201–1204
     [Google Scholar]
  14. Daniel M., Kirchoff E., Czajak S. C., Sehgal P. K., Desrosier R. C. 1992; Protective effects of live attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938–1941
     [Google Scholar]
  15. Feichtinger H., Kaaya E. E., Li S. L., Putkonen P., Ekman M., Mandache E., Grünewald K., Biberfeld G., Biberfeld P. 1993; Pathology of the lymphoid system in cynomolgus monkeys infected with SIVsm. In Animal Models of HIV and Other Retroviral Infections pp 49–63 Edited by Rácz P., Letvin N. L., Gluckman J. C. Basel: Karger;
     [Google Scholar]
  16. Franchini G., Robert-Guroff M., Tartaglia J., Aggarwal A., Abimiku A., Benson J., Markham P., Limbach K., Hurteau G., Fullen J., Aldrich K., Miller N., Sadoff J., Paoletti E., Gallo R. C. 1995; Highly attenuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques. AIDS Research and Human Retroviruses 11:909–920
     [Google Scholar]
  17. Gallimore A., Cranage M., Cook N., Almond N., Bootman J., Rud E., Silvera P., Dennis M., Corcoran T., Stott J., McMichael A., Gotch F. 1995; Early suppression of SIV replication by CD8+ nef -specific cytotoxic T cells in vaccinated macaques. Nature Medicine 1:1167–1173
     [Google Scholar]
  18. Gilljam G. 1993; Envelope glycoproteins of HIV-1, HIV-2 and SIV purified with Galanthus nivalis agglutinin induce strong immune responses. AIDS Research and Human Retroviruses 9:431–438
     [Google Scholar]
  19. Hirsch V. M., Fuerst T. R., Sutter G., Carroll M. W., Yang L. C., Goldstein S., Piatak M. Jr, Elkins W. R., Alvord W. G., Montefiori D. C., Moss B., Lifson J. D. 1996; Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunisation with a trivalent SIV vaccine in modified vaccinia virus Ankara. Journal of Virology 70:3741–3752
     [Google Scholar]
  20. Kuller L., Morton W. R., Benveniste R. E., Tsai C. C., Clark E. A., Gale M. J., Hu S. L., Thouless M. E., Katze M. G. 1990; Inoculation of Macaca fascicularis with simian immunodeficiency virus, SIVmne immunologic, serologic and pathologic changes. Journal of Medical Primatology 19:367–380
     [Google Scholar]
  21. Kuller L., Thompson J., Watanabe R., Iskandriati D., Alpers C. E., Morton W. R., Agy M. B. 1998; Mucosal antibody expression following rapid SIVmne dissemination in intrarectally infected Macaca nemestrina . AIDS Research and Human Retroviruses 14:1345–1356
     [Google Scholar]
  22. Lehner T., Wang Y., Cranage M., Bergmeier L. A., Mitchell E., Tao L., Hall G., Dennis M., Cock N., Brookes R., Klavinski L., Jones I., Doyle C., Ward R. 1996; Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Medicine 2:767–775
     [Google Scholar]
  23. Letvin N. L., Li J., Halloran M., Cranage M. P., Rud E. W., Sodroski J. 1995; Prior infection with a nonpathogenic chimeric simian–human immunodeficiency virus does not efficiently protect macaques against challenge with simian immunodeficiency virus. Journal of Virology 69:4569–4571
     [Google Scholar]
  24. Li S. L., Kaaya E. E., Feichtinger H., Biberfeld G., Biberfeld P. 1993; Immunohistochemical distribution of leucocyte antigens in lymphoid tissues of cynomolgus monkeys (Macaca fascicularis. Journal of Medical Primatology 22:213–221
     [Google Scholar]
  25. Liska V., Lerche N. W., Ruprecht R. 1997; Simultaneous detection of simian retrovirus type D serotypes 1, 2, and 3 by polymerase chain reaction. AIDS Research and Human Retroviruses 13:433–437
     [Google Scholar]
  26. Lohman B. L., McChesney M. B., Miller C. J., McGowan E., Joye S. M., Van Rompay K. K., Reay E., Antipa L., Pedersen N. C., Marthas M. M. 1994; A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. Journal of Virology 68:7021–7029
     [Google Scholar]
  27. Looney D. J., McClure J. M., Kent S. J., Radaelli A., Kraus G., Schmidt A., Steffy K., Greenberg P., Hu S.-L., Morton W. R., Wong-Staal F. 1998; A minimally replicative HIV-2 live-virus vaccine protects M. nemestrina from disease after HIV-2287 challenge. Virology 242:150–160
     [Google Scholar]
  28. Mäkitalo B., Putkonen P., Biberfeld G., Thorstensson R. 2000; Cell-mediated immunity to low doses of SIVsm in cynomolgus macaques did not confer protection against mucosal rechallenge. Vaccine 19:298–307
     [Google Scholar]
  29. Marthas M. L., Sutjipto S., Higgins J., Lohman B., Torten J., Luciw P. A., Marx P. A., Pedersen N. C. 1990; Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV. Journal of Virology 64:3694–3700
     [Google Scholar]
  30. Miller C. J., McChesney M. B., Lü X., Dailey P. J., Chutkowski C., Lu D., Brosio P., Roberts B., Lu Y. 1997; Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239. Journal of Virology 71:1911–1921
     [Google Scholar]
  31. Nilsson C., Thorstensson R., Gilljam G., Sjölander S., Hild K., Broliden K., Åkerblom L., Morein B., Biberfeld G., Putkonen P. 1995; Protection against monkey-cell grown cell-free HIV-2 challenge in macaques immunised with native HIV-2 envelope glycoprotein gp125. Vaccine Research 4:165–175
     [Google Scholar]
  32. Nilsson C., Mäkitalo B., Thorstensson R., Norley S., Binniger-Schinzel D., Cranage M., Rud E., Biberfeld G., Putkonen P. 1998; Live attenuated SIVmac in macaques can induce protection against mucosal infection with SIVsm. AIDS 12:2261–2270
     [Google Scholar]
  33. Öst Å., Baroni C. D., Biberfeld P., Diebold J., Morages A., Noêl H., Pallese G., Rácz P., Schipper M., Tenner-Rácz K., van der Tweel J. G. 1989; Lymphadenopathy in HIV infection: histological classification and staging. Acta Pathologica Microbiologica et Immunologica Scandinavica Suppl 87–15
     [Google Scholar]
  34. Putkonen P., Böttiger B., Warstedt K., Thorstensson R., Albert J., Biberfeld G. 1989a; Experimental infection of cynomolgus monkeys (Macaca fascicularis) with HIV-2. Journal of Acquired Immune Deficiency Syndromes 2:366–373
     [Google Scholar]
  35. Putkonen P., Warstedt K., Thorstensson R., Albert J., Lundgren B., Öberg B., Norrby E., Biberfeld G. 1989b; Experimental infection of cynomolgus monkeys (Macaca fascicularis) with simian immunodeficiency virus (SIVsm). Journal of Acquired Immune Deficiency Syndromes 2:359–365
     [Google Scholar]
  36. Putkonen P., Thorstensson R., Albert J., Hild K., Norrby E., Biberfeld P., Biberfeld G. 1990; Infection of cynomolgus monkeys with HIV-2 protects against pathogenic consequences of a subsequent simian immunodeficiency virus infection. AIDS 4:783–789
     [Google Scholar]
  37. Putkonen P., Thorstensson R., Walther L., Albert J., Åkerblom L., Granquist O., Wadell G., Norrby E., Biberfeld G. 1991; Vaccine protection against HIV-2 infection in cynomolgus monkeys. AIDS Research and Human Retroviruses 3:271–277
     [Google Scholar]
  38. Putkonen P., Kaaya E., Böttiger D., Li S.-L., Nilsson C., Biberfeld P., Biberfeld G. 1992; Clinical features and predictive markers of disease progression in cynomolgus monkeys experimentally infected with simian immunodeficiency virus (SIVsm). AIDS 6:257–263
     [Google Scholar]
  39. Putkonen P., Walther L., Zhang Y., Li S., Nilsson C., Albert J., Biberfeld P., Thorstensson R., Biberfeld G. 1995; Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine. Nature Medicine 1:914–918
     [Google Scholar]
  40. Putkonen P., Mäkitalo B., Böttiger D., Biberfeld G., Thorstensson R. 1997; Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission. Journal of Virology 71:4981–4984
     [Google Scholar]
  41. Quesada-Rolander M., Mäkitalo B., Thorstensson R., Zhang Y. J., Castaños-Vélez E., Biberfeld G., Putkonen P. 1996; Protection against mucosal SIVsm challenge in macaques infected with a chimeric SIV that expresses HIV type 1 envelope. AIDS Research and Human Retroviruses 12:993–999
     [Google Scholar]
  42. ten Haaft P., Verstrepen B., Überla K., Rosenwirth B., Heeney J. 1998; A pathogenic threshold of virus load defined in simian immunodeficiency virus-infected macaques. Journal of Virology 72:10281–10285
     [Google Scholar]
  43. Thorstensson R., Walther L., Putkonen P., Albert J., Biberfeld G. 1991; A capture immunoassay for detection of HIV-2/SIV antigen. Journal of Acquired Immune Deficiency Syndromes 4:374–379
     [Google Scholar]
  44. Wakrim L., Le Grand R., Vaslin B., Cheret A., Matheux F., Theodoro F., Roques P., Nico-Jourdain I., Dormont D. 1996; Superinfection of HIV-2-preinfected macaques after rectal exposure to a primary isolate of SIVmac251. Virology 221:260–270
     [Google Scholar]
  45. Walther L., Grankvist O., Putkonen P., Dias F., Biberfeld G., Thorstensson R. 1996; Nested PCR primers that distinguish between SIVsm and HIV-2. AIDS Research and Human Retroviruses 12:1077–1079
     [Google Scholar]
  46. Wang Y., Tao L., Mitchell E., Bogers W. M. J. M., Doyle C., Bravery C. A., Bergmeier L. A., Kelly C. G., Heeney J. L., Lehner T. 1998; Generation of CD8 suppressor factor and beta chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques. Proceedings of the National Academy of Sciences, USA 95:5223–5228
     [Google Scholar]
  47. Watson A., Ranchalis J., Travis B., McClure J., Sutton W., Johnson P. R., Hu S.-H., Haigwood N. L. 1997; Plasma viremia in macaques infected with simian immunodeficiency virus: viral load early in infection predicts survival. Journal of Virology 71:284–290
     [Google Scholar]
  48. Wyand M. S., Manson K. H., Garcia-Moll M., Montefiori D., Desrosier R. C. 1996; Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. Journal of Virology 70:3724–3733
     [Google Scholar]
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Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys
J. Gen. Virol. 82, 1601 (2001); https://doi.org/10.1099/0022-1317-82-7-1601
/content/journal/jgv/10.1099/0022-1317-82-7-1601
/content/journal/jgv/10.1099/0022-1317-82-7-1601
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