@article{mbs:/content/journal/jgv/10.1099/0022-1317-82-5-1043, author = "Azoulay-Cayla, Arièle and Syan, Sylvie and Brahic, Michel and Bureau, Jean-François", title = "Roles of the H-2Db and H-Kb genes in resistance to persistent Theiler’s murine encephalomyelitis virus infection of the central nervous system", journal= "Journal of General Virology", year = "2001", volume = "82", number = "5", pages = "1043-1047", doi = "https://doi.org/10.1099/0022-1317-82-5-1043", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-5-1043", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Theiler’s murine encephalomyelitis virus, a member of the Picornaviridae family, persists in the spinal cord of susceptible strains of mice. Resistant strains of mice, such as the H-2 b strain, clear the virus infection after an acute encephalomyelitis. The H-2D locus, but not the H-2K locus, has a major effect on this resistance, although both loci code for MHC class I molecules with similar general properties. For the present work, we rendered susceptible H-2 q FVB/N mice transgenic for either the H-2D b gene, the H-2K b gene or a chimeric H-2D b /K b gene in which the exons encoding the peptide-binding groove of the H-2K b gene have been replaced by those of the H-2D b gene. Mice transgenic for either the H-2D b gene or the chimeric H-2D b /K b gene were significantly more resistant to persistent virus infection than mice transgenic for the H-2K b gene, suggesting that the difference in the effects of the H-2D b gene and the H-2K b gene are due to the nature of the peptides presented by these class I molecules.", }