RT Journal Article SR Electronic(1) A1 Paraskevis, D. A1 Magiorkinis, M. A1 Vandamme, A. M. A1 Kostrikis, L. G. A1 Hatzakis, A.YR 2001 T1 Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus and Greece, initially designated ‘subtype I’, reveals a unique complex A/G/H/K/? mosaic pattern JF Journal of General Virology, VO 82 IS 3 SP 575 OP 580 DO https://doi.org/10.1099/0022-1317-82-3-575 PB Microbiology Society, SN 1465-2099, AB Human immunodeficiency virus type 1 (HIV-1) has been classified into three main groups and 11 distinct subtypes. Moreover, several circulating recombinant forms (CRFs) of HIV-1 have been recently documented to have spread widely causing extensive HIV-1 epidemics. A subtype, initially designated I (CRF04_cpx), was documented in Cyprus and Greece and was found to comprise regions of sequence derived from subtypes A and G as well as regions of unclassified sequence. Re-analysis of the three full-length CRF04_cpx sequences that were available revealed a mosaic genomic organization of unique complexity comprising regions of sequence from at least five distinct subtypes, A, G, H, K and unclassified regions. These strains account for approximately 2% of the total HIV-1-infected population in Greece, thus providing evidence of the great capability of HIV-1 to recombine and produce highly divergent strains which can be spread successfully through different infection routes., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-3-575