1887

Abstract

Subgroup B isolates of are less efficient in T lymphocyte transformation when compared with subgroups A or C. Here it is shown that subgroup B strain SMHI encodes a protein, StpB, at a position equivalent to those of the ORFs for the saimiri transforming proteins (Stp) of subgroups A and C. StpB shares little similarity with StpA or StpC, but interacts with the SH2 domain of cellular Src, as does StpA. Thus, factors other than c-Src binding determine the efficiency of primary T cell transformation by

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-82-2-339
2001-02-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/82/2/0820339a.html?itemId=/content/journal/jgv/10.1099/0022-1317-82-2-339&mimeType=html&fmt=ahah

References

  1. Albrecht J. C., Nicholas J., Biller D., Cameron K. R., Biesinger B., Newman C., Wittmann S., Craxton M. A., Coleman H., Fleckenstein B. 1992; Primary structure of the herpesvirus saimiri genome. Journal of Virology 66:5047–5058
    [Google Scholar]
  2. Biesinger B., Trimble J. J., Desrosiers R. C., Fleckenstein B. 1990; The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Virology 176:505–514
    [Google Scholar]
  3. Biesinger B., Müller-Fleckenstein I., Simmer B., Lang G., Wittmann S., Platzer E., Desrosiers R. C., Fleckenstein B. 1992; Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proceedings of the National Academy of Sciences, USA 89:3116–3119
    [Google Scholar]
  4. Biesinger B., Tsygankov A. Y., Fickenscher H., Emmrich F., Fleckenstein B., Bolen J. B., Bröker B. M. 1995; The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. Journal of Biological Chemistry 270:4729–4734
    [Google Scholar]
  5. Choi J. K., Ishido S., Jung J. U. 2000; The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity. Journal of Virology 74:8102–8110
    [Google Scholar]
  6. Desrosiers R. C., Falk L. A. 1982; Herpesvirus saimiri strain variability. Journal of Virology 43:352–356
    [Google Scholar]
  7. Desrosiers R. C., Silva D. P., Waldron L. M., Letvin N. L. 1986; Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. Journal of Virology 57:701–705
    [Google Scholar]
  8. Devergne O., Hatzivassiliou E., Izumi K. M., Kaye K. M., Kleijnen M. F., Kieff E., Mosialos G. 1996; Association of TRAF1, TRAF2, and TRAF3 with an Epstein–Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-κB activation. Molecular and Cellular Biology 16:7098–7108
    [Google Scholar]
  9. Du Z., Lang S. M., Sasseville V. G., Lackner A. A., Ilyinskii P. O., Daniel M. D., Jung J. U., Desrosiers R. C. 1995; Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665–674
    [Google Scholar]
  10. Duboise S. M., Guo J., Czajak S., Desrosiers R. C., Jung J. U. 1998; STP and Tip are essential for herpesvirus saimiri oncogenicity. Journal of Virology 72:1308–1313
    [Google Scholar]
  11. Dunant N. M., Senften M., Ballmer-Hofer K. 1996; Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases. Journal of Virology 70:1323–1330
    [Google Scholar]
  12. Ensser A., Pflanz R., Fleckenstein B. 1997; Primary structure of the alcelaphine herpesvirus 1 genome. Journal of Virology 71:6517–6525
    [Google Scholar]
  13. Fickenscher H., Biesinger B., Knappe A., Wittmann S., Fleckenstein B. 1996; Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes. Journal of Virology 70:6012–6019
    [Google Scholar]
  14. Fleckenstein B., Desrosiers R. C. 1982; Herpesvirus saimiri and herpesvirus ateles. In The Herpesviruses pp 253–332 Edited by Roizman B. New York: Plenum;
    [Google Scholar]
  15. Guo J., Williams K., Duboise S. M., Alexander L., Veazey R., Jung J. U. 1998; Substitution of ras for the herpesvirus saimiri STP oncogene in lymphocyte transformation. Journal of Virology 72:3698–3704
    [Google Scholar]
  16. Isakov N., Biesinger B. 2000; Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by herpesvirus saimiri and other viral gene products. European Journal of Biochemistry 267:3413–3421
    [Google Scholar]
  17. Jung J. U., Desrosiers R. C. 1994; Distinct functional domains of STP-C488 of herpesvirus saimiri. Virology 204:751–758
    [Google Scholar]
  18. Jung J. U., Desrosiers R. C. 1995; Association of the viral oncoprotein STP-C488 with cellular ras. Molecular and Cellular Biology 15:6506–6512
    [Google Scholar]
  19. Jung J. U., Trimble J. J., King N. W., Biesinger B., Fleckenstein B. W., Desrosiers R. C. 1991; Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri. Proceedings of the National Academy of Sciences, USA 88:7051–7055
    [Google Scholar]
  20. Jung J. U., Choi J. K., Ensser A., Biesinger B. 1999; Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis. Seminars in Cancer Biology 9:231–239
    [Google Scholar]
  21. Kretschmer C., Murphy C., Biesinger B., Beckers J., Fickenscher H., Kirchner T., Fleckenstein B., Rüther U. 1996; A herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice. Oncogene 12:1609–1616
    [Google Scholar]
  22. Lang S. M., Iafrate A. J., Stahl-Hennig C., Kuhn E. M., Nisslein T., Kaup F. J., Haupt M., Hunsmann G., Skowronski J., Kirchhoff F. 1997; Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nature Medicine 3:860–865
    [Google Scholar]
  23. Lee H., Trimble J. J., Yoon D. W., Regier D., Desrosiers R. C., Jung J. U. 1997; Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src. Journal of Virology 71:3817–3825
    [Google Scholar]
  24. Lee H., Choi J. K., Li M., Kaye K., Kieff E., Jung J. U. 1999; Role of cellular tumor necrosis factor receptor-associated factors in NF-κB activation and lymphocyte transformation by herpesvirus saimiri STP. Journal of Virology 73:3913–3919
    [Google Scholar]
  25. Longan L., Longnecker R. 2000; Epstein–Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. Journal of General Virology 81:2245–2252
    [Google Scholar]
  26. Medveczky P., Szomolanyi E., Desrosiers R. C., Mulder C. 1984; Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity. Journal of Virology 52:938–944
    [Google Scholar]
  27. Moarefi I., LaFevre-Bernt M., Sicheri F., Huse M., Lee C. H., Kuriyan J., Miller W. T. 1997; Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385:650–653
    [Google Scholar]
  28. Murphy C., Kretschmer C., Biesinger B., Beckers J., Jung J., Desrosiers R. C., Müller-Hermelink H. K., Fleckenstein B. W., Rüther U. 1994; Epithelial tumours induced by a herpesvirus oncogene in transgenic mice. Oncogene 9:221–226
    [Google Scholar]
  29. Murthy S. C., Trimble J. J., Desrosiers R. C. 1989; Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. Journal of Virology 63:3307–3314
    [Google Scholar]
  30. Songyang Z., Shoelson S. E., Chaudhuri M., Gish G., Pawson T., Haser W. G., King F., Roberts T., Ratnofsky S., Lechleider R. J. 1993; SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778
    [Google Scholar]
  31. Songyang Z., Carraway K. L., Eck M. J., Harrison S. C., Feldman R. A., Mohammadi M., Schlessinger J., Hubbard S. R., Smith D. P., Eng C., Lorenzo M. J., Ponder B. J., Mayer B. J., Cantley L. C. 1995; Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373:536–539
    [Google Scholar]
  32. Szomolanyi E., Medveczky P., Mulder C. 1987; In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri. Journal of Virology 61:3485–3490
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-82-2-339
Loading
/content/journal/jgv/10.1099/0022-1317-82-2-339
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error