1887

Abstract

A viral protein of approximately 82 kDa is the only structural protein of human cytomegalovirus (CMV) that is strongly immunogenic during natural infection and the corresponding gene of which is still unknown. In this work, strong evidence is presented that this protein is the product of UL25.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-82-2-335
2001-02-01
2024-12-12
Loading full text...

Full text loading...

/deliver/fulltext/jgv/82/2/0820335a.html?itemId=/content/journal/jgv/10.1099/0022-1317-82-2-335&mimeType=html&fmt=ahah

References

  1. Baldick C. J. Jr, Shenk T. 1996; Proteins associated with purified human cytomegalovirus particles. Journal of Virology 70:6097–6105
    [Google Scholar]
  2. Battista M. C., Bergamini G., Boccuni M. C., Campanini F., Ripalti A., Landini M. P. 1999; Expression and characterization of a novel structural protein of human cytomegalovirus, pUL25. Journal of Virology 73:3800–3809
    [Google Scholar]
  3. Britt W. J., Alford C. A. 1996; Cytomegalovirus. In Fields Virology pp 2493–2523 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  4. Gleaves C. A., Smith T. F., Shuster E. A., Pearson G. R. 1984; Rapid detection of cytomegalovirus in MRC-5 cells inoculated with urine specimens by using low-speed centrifugation and monoclonal antibody to an early antigen. Journal of Clinical Microbiology 19:917–919
    [Google Scholar]
  5. Ho M. 1991; Cytomegalovirus. Biology and Infection, 2nd edn. New York: Plenum Medical Press;
    [Google Scholar]
  6. Jahn G., Plachter B. 1993; Diagnostics of persistent viruses: human cytomegalovirus as an example. Intervirology 35:60–72
    [Google Scholar]
  7. Landini M. P., Mach M. 1995; Searching for antibodies specific for human cytomegalovirus: is it diagnostically useful? When and how. Scandinavian Journal of Infectious Diseases Supplementum 99:18–23
    [Google Scholar]
  8. Lazzarotto T., Ripalti A., Bergamini G., Battista M. C., Spezzacatena P., Campanini F., Pradelli P., Varani S., Gabrielli L., Maine G. T., Landini M. P. 1998; Development of a new cytomegalovirus (CMV) immunoglobulin M (IgM) immunoblot for detection of CMV-specific IgM. Journal of Clinical Microbiology 36:3337–3341
    [Google Scholar]
  9. Lazzarotto T., Spezzacatena P., Varani S., Gabrielli L., Pradelli P., Guerra B., Landini M. P. 1999; Anticytomegalovirus (anti-CMV) immunoglobulin G avidity in identification of pregnant women at risk of transmitting congenital CMV infection. Clinical and Diagnostic Laboratory Immunology 6:127–129
    [Google Scholar]
  10. Mocarski E. S. Jr(1996; Cytomegaloviruses and their replication. In Fields Virology pp 2447–2492 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  11. Revello M. G., Zavattoni M., Percivalle E., Grossi P., Gerna G. 1989; Correlation between immunofluorescent detection of human cytomegalovirus immediate early antigens in polymorphonuclear leukocytes and viremia. Journal of Infectious Diseases 160:159–160
    [Google Scholar]
  12. Robinson J. M., Pilot-Matias T. J., Pratt S. D., Patel C. B., Bevirt T. S., Hunt J. C. 1993; Analysis of the humoral response to the flagellin protein of Borrelia burgdorferi : cloning of regions capable of differentiating Lyme disease from syphilis. Journal of Clinical Microbiology 31:629–635
    [Google Scholar]
  13. Spaete R. R., Gehrz R. C., Landini M. P. 1994; Human cytomegalovirus structural proteins. Journal of General Virology 75:3287–3308
    [Google Scholar]
  14. van der Bij W., Torensma R., van Son W. J., Anema J., Schirm J., Tegzess A. M., The T. H. 1988; Rapid immunodiagnosis of active cytomegalovirus infection by monoclonal antibody staining of blood leucocytes. Journal of Medical Virology 25:179–188
    [Google Scholar]
  15. Zini N., Battista M. C., Santi S., Riccio M., Bergamini G., Landini M. P., Maraldi N. M. 1999; The novel structural protein of human cytomegalovirus, pUL25, is localized in the viral tegument. Journal of Virology 73:6073–6075
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-82-2-335
Loading
/content/journal/jgv/10.1099/0022-1317-82-2-335
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error