1887

Abstract

Twenty-nine Danish virus isolates and 14 serum samples from patients with mumps were genotyped by nucleotide sequencing of the small hydrophobic (SH) protein gene and the deduced 57 amino acid sequences were aligned with sequences of mumps virus strains published previously. Four neurovirulent genotypes of the SH protein gene, genotypes C, D, H and a new genotype, designated J, were found. There was a dynamic fluctuation of the different genotypes over the two decade period of time. Genotype J was found from 1981 to 1988; genotypes C and H exhibited a similar distribution in time. Genotype D was found between 1979 and 1982, it then disappeared and reappeared again in 1996. From 1996 onwards, genotype D was found to be the predominant genotype, which is in contrast to the situation seen in the neighbouring country of Sweden, where, since 1985, only genotype A has been found.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-82-11-2675
2001-11-01
2024-12-07
Loading full text...

Full text loading...

/deliver/fulltext/jgv/82/11/0822675a.html?itemId=/content/journal/jgv/10.1099/0022-1317-82-11-2675&mimeType=html&fmt=ahah

References

  1. Afzal M. A., Buchanan J., Heath A. B., Minor P. D. 1997a; Clustering of mumps virus isolates by SH gene sequence only partially reflects geographical origin. Archives of Virology 142:227–238
    [Google Scholar]
  2. Afzal M. A., Buchanan J., Dias J. A., Cordeiro M., Bentley M. L., Shorrock C. A., Minor P. D. 1997b; RT–PCR based diagnosis and molecular characterisation of mumps viruses derived from clinical specimens collected during the 1996 mumps outbreak in Portugal. Journal of Medical Virology 52:349–353
    [Google Scholar]
  3. Briss P. A., Fehrs L. J., Parker R. A., Wright P. F., Sannella E. C., Hutcheson R. H., Schaffner W. 1994; Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity. Journal of Infectious Diseases 169:77–82
    [Google Scholar]
  4. Cheek J. E., Baron R., Atlas H., Wilson D. L., Crider R.D. Jr 1995; Mumps outbreak in a highly vaccinated school population. Evidence for large-scale vaccination failure. Archives of Pediatric and Adolescence Medicine 149:774–778
    [Google Scholar]
  5. Elango N., Varsanyi T. M., Kövamees J., Norrby E. 1988; Molecular cloning and characterization of six genes, determination of gene order and intergenic sequences and leader sequence of mumps virus. Journal of General Virology 69:2893–2900
    [Google Scholar]
  6. Elango N., Kövamees J., Varsanyi T. M., Norrby E. 1989; mRNA sequence and deduced amino acid sequence of the mumps virus small hydrophobic protein gene. Journal of Virology 63:1413–1415
    [Google Scholar]
  7. Elliott G. D., Afzal M. A., Martin S. J., Rima B. K. 1989; Nucleotide sequence of the matrix, fusion and putative SH protein genes of mumps virus and their deduced amino acid sequences. Virus Research 12:61–75
    [Google Scholar]
  8. Germann D., Ströhle A., Eggenberger K., Steiner C. A., Matter L. 1996; An outbreak of mumps in a population partially vaccinated with the Rubini strain. Scandinavian Journal of Infectious Diseases 28:235–238
    [Google Scholar]
  9. Hersh B. S., Fine P. E. M., Kent W. K., Cochi S. L., Kahn L. H., Zell E. R., Hays P. L., Wood C. L. 1991; Mumps outbreak in a highly vaccinated population. Journal of Pediatrics 119:187–193
    [Google Scholar]
  10. Jin L., Beard S., Brown D. W. G. 1999; Genetic heterogeneity of mumps virus in the United Kingdom: identification of two new genotypes. Journal of Infectious Diseases 180:829–833
    [Google Scholar]
  11. Kim S. H., Song K.-J., Shin Y. K., Kim J. H., Choi S. M., Park K. S., Baek L. J., Lee Y. J., Song J.-W. 2000; Phylogenetic analysis of the small hydrophobic (SH) gene of mumps virus in Korea: identification of a new genotype. Microbiology and Immunology 44:173–177
    [Google Scholar]
  12. Künkel U., Schreier E., Siegl G., Schultze D. 1994; Molecular characterization of mumps virus strains circulating during an epidemic in eastern Switzerland 1992/93. Archives of Virology 136:433–438
    [Google Scholar]
  13. Künkel U., Driesel G., Henning U., Gerike E., Willers H., Schreier E. 1995; Differentiation of vaccine and wild mumps viruses by polymerase chain reaction and nucleotide sequencing of the SH gene. Journal of Medical Virology 45:121–126
    [Google Scholar]
  14. Merz D. C., Wolinsky J. S. 1981; Biochemical features of mumps virus neuraminidases and their relationship with pathogenicity. Virology 114:218–227
    [Google Scholar]
  15. Nöjd J., Tecle T., Samuelsson A., Örvell C. 2001; Mumps virus neutralizing antibodies do not protect against reinfection with a heterologous mumps virus genotype. Vaccine 19:1727–1731
    [Google Scholar]
  16. Örvell C. 1984; The reactions of monoclonal antibodies with structural proteins of mumps virus. Journal of Immunology 132:2622–2629
    [Google Scholar]
  17. Örvell C., Kalantari M., Johansson B. 1997a; Characterization of five conserved genotypes of the mumps virus small hydrophobic (SH) protein gene. Journal of General Virology 78:91–95
    [Google Scholar]
  18. Örvell C., Alsheikhly A.-R., Kalantari M., Johansson B. 1997b; Characterization of genotype-specific epitopes of the HN protein of mumps virus. Journal of General Virology 78:3187–3193
    [Google Scholar]
  19. Rima B. K., Alexander D. J., Billeter M. A., Collins P. L., Kingsbury D. W., Lipkind M. A., Nagai Y., Örvell C., Pringle C. R., ter Meulen V. 1995; Paramyxoviridae. In Virus Taxonomy. Sixth Report of the International Committee on Taxonomy of Viruses pp 268–274 Edited by Murphy F. A., Fauquet C. M., Bishop D. H. L., Ghabrial S. A., Jarvis A. W., Martelli G. P., Mayo M. A., Summers M. D. New York: Springer–Verlag;
    [Google Scholar]
  20. Rubin S. A., Pletnikov M., Carbone K. M. 1998; Comparison of the neurovirulence of a vaccine and a wild-type mumps virus strain in the developing rat brain. Journal of Virology 72:8037–8042
    [Google Scholar]
  21. Rubin S. A., Pletnikov M., Taffs R., Snoy P. J., Kobasa D., Brown E. G., Wright K. E., Carbone K. M. 2000; Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans. Journal of Virology 74:5382–5384
    [Google Scholar]
  22. Saito H., Takahashi Y., Harata S., Tanaka K., Sano T., Suto T., Yamada A., Yamazaki S., Morita M. 1996; Isolation and characterization of mumps virus strains in a mumps outbreak with a high incidence of aseptic meningitis. Microbiology and Immunology 40:271–275
    [Google Scholar]
  23. Ströhle A., Bernasconi C., Germann D. 1996; A new mumps virus lineage found in the 1995 mumps outbreak in western Switzerland identified by nucleotide sequence analysis of the SH gene. Archives of Virology 141:733–741
    [Google Scholar]
  24. Takahashi M., Nakayama T., Kashiwagi Y., Takami T., Sonoda S., Yamanaka T., Ochiai H., Ihara T., Tajima T. 2000; Single genotype of measles virus is dominant whereas several genotypes of mumps virus are co-circulating. Journal of Medical Virology 62:278–285
    [Google Scholar]
  25. Takeuchi K., Tanabayashi K., Hishiyama M., Yamada A. 1996; The mumps virus SH protein is a membrane protein and not essential for virus growth. Virology 225:156–162
    [Google Scholar]
  26. Tecle T., Johansson B., Jejcic A., Forsgren M., Örvell C. 1998; Characterization of three co-circulating genotypes of the small hydrophobic gene of mumps virus. Journal of General Virology 79:2929–2937
    [Google Scholar]
  27. Van de Peer Y., De Wachter R. 1994; TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment. Computer Applications in the Biosciences 10:569–570
    [Google Scholar]
  28. Wharton M., Cochi S. L., Hutcheson R. H., Bistowish J. M., Schaffner W. 1988; A large outbreak of mumps in the post-vaccine era. Journal of Infectious Diseases 158:1253–1260
    [Google Scholar]
  29. Wu L., Bai Z., Li Y., Rima B. K., Afzal M. A. 1998; Wild type mumps viruses circulating in China establish a new genotype. Vaccine 16:281–285
    [Google Scholar]
  30. Yates P. J., Afzal M. A., Minor P. D. 1996; Antigenic and genetic variation of the HN protein of mumps virus strains. Journal of General Virology 77:2491–2497
    [Google Scholar]
/content/journal/jgv/10.1099/0022-1317-82-11-2675
Loading
/content/journal/jgv/10.1099/0022-1317-82-11-2675
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error