@article{mbs:/content/journal/jgv/10.1099/0022-1317-82-10-2509, author = "Paraskevis, D. and Magiorkinis, E. and Magiorkinis, G. and Anastassopoulou, C. and Lazanas, M. and Chrysos, G. and Vandamme, A. M. and Hatzakis, A.", title = "Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype", journal= "Journal of General Virology", year = "2001", volume = "82", number = "10", pages = "2509-2514", doi = "https://doi.org/10.1099/0022-1317-82-10-2509", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-10-2509", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Recombination is one of several factors that contribute to the great genetic diversity of human immunodeficiency virus type 1 (HIV-1). In the current study, analysis of the full-length genome of a novel complex mosaic HIV-1 isolate (99GR303) from a Greek sailor who was possibly infected in Sierra Leone, Africa is presented. The 99GR303 isolate was found to comprise genomic regions belonging to subtypes A, G, J and K as well as of regions of a subtype that remains unclassified. For a partial region of env as well as vpr, no apparent similarity to the known HIV-1 subtypes or to any of the circulating recombinant forms was found. In fact, in the partial env gene, including the C2-V3 region, the 99GR303 isolate formed a new clade, suggesting the existence of an additional HIV-1 subtype. Thus, novel recombinants embody partial genomic regions which may have originated either from subtypes that existed in the past and became extinct or from contemporary subtypes that are extremely rare.", }