RT Journal Article SR Electronic(1) A1 Nicholl, Mary Jane A1 Robinson, Laurence H. A1 Preston, Chris M. YR 2000 T1 Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1 JF Journal of General Virology, VO 81 IS 9 SP 2215 OP 2218 DO https://doi.org/10.1099/0022-1317-81-9-2215 PB Microbiology Society, SN 1465-2099, AB Previous studies have shown that infection of human fibroblasts with human cytomegalovirus (HCMV) results in activation of cellular interferon-responsive gene expression. We demonstrate here that infection of human fibroblasts with herpes simplex virus type 1 (HSV-1) in the absence of de novo protein synthesis also induces the expression of interferon-responsive genes. Five genes tested (encoding ISG54, IFI56, ISG15, 9-27 and MxA) were activated by infection with HSV-1, although the degree of response varied between the individual genes. HSV-1 was a less efficient inducer than HCMV. The effect was a consequence of binding of the virus particle to the cell surface or of the presence of virion components within the infected cell. Induction was mediated by a pathway other than the mechanism through which interferon-α mediates its effects on cellular gene expression., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-9-2215