1887

Abstract

The fowl adenovirus type 8 (FAdV-8) genome was sequenced and found to be 45063 nucleotides in length, the longest adenovirus (AdV) genome for which the complete nucleotide sequence has been determined so far. No regions homologous to early regions 1, 3 and 4 (E1, E3 and E4) of mastadenoviruses were recognized. Gene homologues for early region 2 (E2) proteins, intermediate protein IVa2 and late proteins were found by their similarities to protein sequences from other AdVs. However, sequences homologous to intermediate protein IX and late protein V could not be identified. Sequences for virus-associated RNA could also not be recognized. Two regions of repeated sequences were found on the FAdV-8 genome. The shorter repeat region contained five identical and contiguous direct repeats that were each 33 bp long, while the longer repeat region was made of 13 identical and contiguous, 135 bp long repeated subunits.

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2000-07-01
2024-12-10
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References

  1. Alexander, H. S., Huber, P., Cao, J. X., Krell, P. J. & Nagy, É. (1998). Growth characteristics of fowl adenovirus type 8 in a chicken hepatoma cell line.Journal of Virological Methods 74, 9-14.[CrossRef] [Google Scholar]
  2. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990). Basic local alignment search tool.Journal of Molecular Biology 215, 403-410.[CrossRef] [Google Scholar]
  3. Cao, J. X., Krell, P. J. & Nagy, É. (1998). Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome.Journal of General Virology 79, 2507-2516. [Google Scholar]
  4. Chiocca, S., Kurzbauer, R., Schaffner, G., Baker, A., Mautner, V. & Cotton, M. (1996). The complete DNA sequence and genomic organization of the avian adenovirus CELO.Journal of Virology 70, 2939-2949. [Google Scholar]
  5. Chiocca, S., Baker, A. & Cotton, M. (1997). Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus.Journal of Virology 71, 3168-3177. [Google Scholar]
  6. Clavijo, A., Krell, P. J. & Nagy, É. (1996). Molecular cloning and restriction enzyme mapping of avian adenovirus type 8 DNA.Virus Research 45, 93-99.[CrossRef] [Google Scholar]
  7. Dhillon, A. S. & Jack, O. K. (1997). The oncogenic potential of eleven avian adenovirus strains.Avian Diseases 41, 247-251.[CrossRef] [Google Scholar]
  8. Gelderblom, H. & Maichle-Lauppe, I. (1982). The fibers of fowl adenoviruses.Archives of Virology 72, 289-298.[CrossRef] [Google Scholar]
  9. Ghadge, G. D., Malhotra, P., Furtado, M. R., Dhar, R. & Thimmapaya, B. (1994). In vitro analysis of virus-associated RNA I (VAI RNA): inhibition of the double-stranded RNA-activated protein kinase PKR by VAI RNA mutants correlates with the in vivo phenotype and the structural integrity of the central domain.Journal of Virology 68, 4137-4151. [Google Scholar]
  10. Ghosh-Choudhury, G., Haj-Ahmad, Y. & Graham, F. L. (1987). Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes.EMBO Journal 6, 1733-1739. [Google Scholar]
  11. Harrach, B., Meehan, B. M., Benko, M., Adair, B. M. & Todd, D. (1997). Close phylogenetic relationship between egg drop syndrome virus, bovine adenovirus serotype 7 and ovine adenovirus strain 287.Virology 229, 302-306.[CrossRef] [Google Scholar]
  12. Hess, M., Blocker, H. & Brandt, P. (1997). The complete nucleotide sequence of egg drop syndrome virus: an intermediate between mastadenoviruses and aviadenoviruses.Virology 238, 145-156.[CrossRef] [Google Scholar]
  13. Lutz, P., Rosa-Calatrava, M. & Kedinger, C. (1997). The product of the adenovirus intermediate gene IX is a transcriptional activator.Journal of Virology 71, 5102-5109. [Google Scholar]
  14. Ma, Y. & Mathews, M. B. (1996). Structure, function and evolution of adenovirus-associated RNA: a phylogenetic approach.Journal of Virology 70, 5083-5099. [Google Scholar]
  15. McFerran, J. B. (1996). Egg drop syndrome. In Diseases of Poultry, pp. 633-642. Edited by B. W. Calnek. Ames, IA, USA: Iowa State University Press.
  16. Monreal, G. (1992). Adenoviruses and adeno-associated viruses of poultry.Poultry Science Review 92, 1-27. [Google Scholar]
  17. Pallister, J., Wright, P. J. & Sheppard, M. (1996). A single gene encoding the fiber is responsible for variations in virulence in the fowl adenoviruses.Journal of Virology 70, 5115-5122. [Google Scholar]
  18. Pierson, F. W. & Domermuth, C. H. (1996). Hemorrhagic enteritis, marble spleen disease and related infections. In Diseases of Poultry, pp. 624-633. Edited by B. W. Calnek. Ames, IA, USA: Iowa State University Press.
  19. Pitcovski, J., Mualem, M., Rei-Koren, Z., Krispel, S., Schmueli, E., Peretz, Y., Gutter, B., Gallili, G. E., Michael, A. & Goldberg, D. (1998). The complete nucleotide sequence and genome organization of the avian adenovirus, hemorrhagic enteritis virus.Virology 249, 307-315.[CrossRef] [Google Scholar]
  20. Sheppard, M., Werner, W., McCoy, R. J. & Johnson, M. (1998a). The major late promoter and bipartite leader sequence of fowl adenovirus.Archives of Virology 143, 537-548.[CrossRef] [Google Scholar]
  21. Sheppard, M., Werner, W., Tsatas, E., McCoy, R. J., Prowse, S. & Johnson, M. (1998b). Fowl adenovirus recombinant expressing VP2 of infectious bursal diseases virus induces protective immunity against bursal disease.Archives of Virology 143, 915-930.[CrossRef] [Google Scholar]
  22. Tribouley, C., Lutz, P., Staub, A. & Kedinger, C. J. (1994). The product of the adenovirus intermediate gene IVa2 is a transcriptional activator of the major late promoter.Journal of Virology 68, 4450-4457. [Google Scholar]
  23. Venktesh, A., Watt, F., Xu, Z. Z. & Both, G. W. (1998). Ovine adenovirus (OAV287) lacks a virus-associated RNA gene.Journal of General Virology 79, 509-516. [Google Scholar]
  24. Vrati, S., Brookes, D. E., Strike, P., Khatri, A., Boyle, D. B. & Both, G. W. (1996). Unique genome arrangement of an ovine adenovirus: identification of new proteins and proteinase cleavage sites.Virology 220, 186-199.[CrossRef] [Google Scholar]
  25. Weiss, R. S., Lee, S., Prasad, B. V. V. & Javier, R. T. (1997). Human adenovirus early region 4 open reading frame 1 genes encode growth transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes.Journal of Virology 71, 1857-1870. [Google Scholar]
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