1887

Abstract

A recombinant vaccine, produced by using a highly attenuated smallpox vaccine (LC16mO) as a vector and which expresses the rinderpest virus (RPV) haemagglutinin protein, has been developed. The properties of this vaccine, including its heat stability, efficacy in short-term trials, safety and genetic stability, have been confirmed in an earlier report. In the present study, the duration of the protective immunity generated by the vaccine in cattle was examined for up to 3 years following the administration of a single vaccination dose of 10 p.f.u. The vaccinated cattle were kept for 2 (group I) or 3 years (group II) and then challenged with a highly virulent strain of RPV. Four of five vaccinated cattle in group I and all six cattle in group II survived the challenge, some showing solid immunity without any clinical signs of rinderpest. Neutralizing antibodies were maintained at a significant level for up to 3 years and they increased rapidly following challenge. Lymphocyte proliferative responses to RPV were examined in group II cattle and were observed in four of the six vaccinated cattle in this group. The long-lasting protective immunity, in addition to the other properties confirmed previously, indicate the practical usefulness of this vaccine for field use.

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2000-06-01
2024-11-05
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References

  1. Asano, K., Tsukiyama, K., Shibata, S., Yamaguchi, K., Momoki, T., Maruyama, T., Kohara, M., Miki, K., Sugimoto, M., Yoshikawa, Y., Nagata, T. & Yamanouchi, K. (1991). Immunological and virological characterization of improved construction of recombinant vaccinia virus expressing rinderpest virus hemagglutinin. Archives of Virology 116, 81-90.[CrossRef] [Google Scholar]
  2. Barrett, T. & Rossiter, P. B. (1999). Rinderpest: the disease and its impact on humans and animals. Advances in Virus Research 53, 89-110. [Google Scholar]
  3. Barrett, T., Forsyth, M. A., Inui, K., Wamwayi, H. M., Kock, R., Wambua, J., Mwanzia, J. & Rossiter, P. B. (1998). Rediscovery of the second African lineage of rinderpest virus: its epidemiological significance. Veterinary Record 142, 669-671.[CrossRef] [Google Scholar]
  4. Bassiri, M., Ahmad, S., Giavedoni, L., Jones, L., Saliki, J. T., Mebus, C. & Yilma, T. (1993). Immunological responses of mice and cattle to baculovirus-expressed F and H proteins of rinderpest virus: lack of protection in the presence of neutralizing antibody. Journal of Virology 67, 1255-1261. [Google Scholar]
  5. Belsham, G. J., Anderson, E. C., Murray, P. K., Anderson, J. & Barrett, T. (1989). Immune response and protection of cattle and pigs generated by a vaccinia virus recombinant expressing the F protein of rinderpest virus. Veterinary Record 124, 655-658.[CrossRef] [Google Scholar]
  6. Forsyth, M. A. & Barrett, T. (1995). Evaluation of polymerase chain reaction for the detection and characterisation of rinderpest and peste des petits ruminants viruses for epidemiological studies. Virus Research 39, 151-163.[CrossRef] [Google Scholar]
  7. Giavedoni, L., Jones, L., Mebus, C. & Yilma, T. (1991). A vaccinia virus double recombinant expressing the F and H genes of rinderpest virus protects cattle against rinderpest and causes no pock lesions. Proceedings of the National Academy of Sciences, USA 88, 8011-8015.[CrossRef] [Google Scholar]
  8. Giraudon, P. & Wild, T. F. (1985). Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity. Virology 144, 46-58.[CrossRef] [Google Scholar]
  9. Hashizume, S., Yoshizawa, H., Morita, M. & Suzuki, K. (1985). Properties of attenuated mutant of vaccinia virus, LC16m8, derived from Lister strain. In Vaccinia Viruses as Vectors for Vaccine Antigens, pp. 87-99. Edited by J. V. Quinnan. New York: Elsevier.
  10. Inui, K., Barrett, T., Kitching, R. P. & Yamanouchi, K. (1995). Long-term immunity in cattle vaccinated with a recombinant rinderpest vaccine. Veterinary Record 137, 669-670. [Google Scholar]
  11. Jones, L., Giavedoni, L., Saliki, J. T., Brown, C., Mebus, C. & Yilma, T. (1993). Protection of goats against peste des petits ruminants with a vaccinia virus double recombinant expressing the F and H genes of rinderpest virus. Vaccine 11, 961-964.[CrossRef] [Google Scholar]
  12. Kobune, F., Sakata, H., Sugiyama, M. & Sugiura, A. (1991). B95a, a marmoset lymphoblastoid cell line, as a sensitive host for rinderpest virus. Journal of General Virology 72, 687-692.[CrossRef] [Google Scholar]
  13. Office International des Epizooties (1989).Report of the Expert Consultation on Requirements for Vaccinia–Rinderpest Recombinant (VRR) Vaccines, Paris, 21–24 August 1989. Reference 58 SG/13 CS 4c. Paris: OIE.
  14. Ohishi, K., Suzuki, H., Yamamoto, T., Maruyama, T., Miki, K., Ikawa, Y., Numakunai, S., Okada, K., Ohshima, K.-i. & Sugimoto, M. (1991). Protective immunity against bovine leukaemia virus (BLV) induced in carrier sheep by inoculation with a vaccinia virus–BLV env recombinant: association with cell-mediated immunity. Journal of General Virology 72, 1887-1892.[CrossRef] [Google Scholar]
  15. Ohishi, K., Inui, K., Yamanouchi, K. & Barrett, T. (1999). Cell-mediated immune responses in cattle vaccinated with a vaccinia virus recombinant expressing the nucleocapsid protein of rinderpest virus. Journal of General Virology 80, 1627-1634. [Google Scholar]
  16. Romero, C. H., Barrett, T., Chamberlain, R. W., Kitching, R. P., Fleming, M. & Black, D. N. (1994). Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses. Virology 204, 425-429.[CrossRef] [Google Scholar]
  17. Rossiter, P. B., Hussain, M., Raja, R. H., Moghul, W., Khan, Z. & Broadbent, D. W. (1998). Cattle plague in Shangri-La: observations on a severe outbreak of rinderpest in northern Pakistan 1994–1995. Veterinary Record 143, 39-42.[CrossRef] [Google Scholar]
  18. Sato, T. A., Hayami, M. & Yamanouchi, K. (1981). Analysis of structural proteins of measles, canine distemper, and rinderpest viruses. Japanese Journal of Medical Science and Biology 34, 355-364.[CrossRef] [Google Scholar]
  19. Taylor, W. P. (1986). Epidemiology and control of rinderpest. Revue Scientifique et Technique Office International des Epizooties 5, 407-410. [Google Scholar]
  20. Wamwayi, H. M., Fleming, M. & Barrett, T. (1995). Characterisation of African isolates of rinderpest virus. Veterinary Microbiology 44, 151-163.[CrossRef] [Google Scholar]
  21. Yamanouchi, K. & Barrett, T. (1994). Progress in the development of a heat-stable recombinant rinderpest vaccine using an attenuated vaccinia virus vector. Revue Scientifique et Technique Office International des Epizooties 13, 721-735. [Google Scholar]
  22. Yamanouchi, K., Inui, K., Sugimoto, M., Asano, K., Nishimaki, F., Kitching, R. P., Takamatsu, H. & Barrett, T. (1993). Immunisation of cattle with a recombinant vaccinia vector expressing the haemagglutinin gene of rinderpest virus. Veterinary Record 132, 152-156.[CrossRef] [Google Scholar]
  23. Yamanouchi, K., Barrett, T. & Kai, C. (1998). New approaches to the development of virus vaccines for veterinary use. Revue Scientifique et Technique Office International des Epizooties 17, 641-653. [Google Scholar]
  24. Yilma, T., Hsu, D., Jones, L., Owens, S., Grubman, M., Mebus, C., Yamanaka, M. & Dale, B. (1988). Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science 242, 1058-1061.[CrossRef] [Google Scholar]
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