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Journal of General Virology header logo Journal of General Virology

Volume 81, Issue 4

Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection No Access

Abstract

Coxsackievirus A21 (CAV-21) employs a cell receptor complex of decay-accelerating factor (DAF) and intercellular adhesion molecule-1 (ICAM-1) for cell infectivity. In this study, the nature of potential extra- and/or intracellular interactions between DAF and ICAM-1 involved in picornaviral cell entry was investigated. Firstly, it was shown that intracellular interplay between DAF and ICAM-1 is not required for CAV-21 infection, as CAV-21 lytic infection mediated via the DAF/ICAM-1 receptor complex is not inhibited by replacement of the transmembrane and cytoplasmic domains of ICAM-1 with those from an unrelated cell surface molecule, CD36. By immunoprecipitation, chemical cross-linking and picornaviral binding assays, the existence of a close spatial association between DAF and ICAM-1 on the surface of ICAM-1-transfected RD cells was confirmed. Furthermore, it was shown that potential extracellular DAF/ICAM-1 interactions are likely to occur in an area on or proximal to DAF SCR3 and may influence the route of CAV-21 cell entry.

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© Microbiology Society
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/content/journal/jgv/10.1099/0022-1317-81-4-889
2000-04-01
2025-05-16
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/content/journal/jgv/10.1099/0022-1317-81-4-889
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Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection
J. Gen. Virol. 81, 889 (2000); https://doi.org/10.1099/0022-1317-81-4-889
/content/journal/jgv/10.1099/0022-1317-81-4-889
/content/journal/jgv/10.1099/0022-1317-81-4-889
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