1887

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Volume 81, Issue 2

Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an model Free

Abstract

The pathogenic properties of four primary human immunodeficiency virus type 2 (HIV-2) isolates and two primary HIV-2 biological clones were studied in an human-to-mouse chimeric model. The cell-associated viral load and the ability to reduce the severity of the induced graft-versus-host disease symptoms, the CD4/CD8 ratio and the level of repopulation of the mouse tissues by the graft, were determined. All HIV-2 strains, irrespective of their biological phenotype, replicated to high titres and significantly reduced graft-versus-host disease symptoms as well as the CD4/CD8 ratios. Reduction of graft repopulation caused by infection with the respective HIV-2 strains showed that the replication rate, syncytium-inducing capacity and ability to infect human macrophages did influence the pathogenic potential whereas broadening of coreceptor usage did not.

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© Microbiology Society
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2000-02-01
2024-04-19
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Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model
J. Gen. Virol. 81, 507 (2000); https://doi.org/10.1099/0022-1317-81-2-507
/content/journal/jgv/10.1099/0022-1317-81-2-507
/content/journal/jgv/10.1099/0022-1317-81-2-507
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