1887

Abstract

(RVFV) is the causative agent of Rift Valley fever, a widespread disease of domestic animals and humans in sub-Saharan Africa. Laboratory rats have frequently been used as an animal model for studying the pathogenesis of Rift Valley fever. It is shown here that Lewis rats (LEW/mol) are susceptible to infection with RVFV, whereas Wistar–Furth (WF/mol) rats are resistant to RVFV infection. LEW/mol rats developed acute hepatitis and died after infection with RVFV strain ZH548, whereas WF/mol rats survived the infection. Cross-breeding of resistant WF/mol rats with susceptible LEW/mol rats demonstrated that resistance is segregated as a single dominant gene. Primary hepatocytes but not glial cells from WF/mol rats showed the resistant phenotype in cell culture, indicating that resistance was cell type-specific. Moreover, when cultured hepatocytes were stimulated with interferon (IFN) type I there was no indication of a regulatory role of IFN in the RVFV-resistance gene expression in WF/mol rats. Interestingly, previous reports have shown that LEW rats from a different breeding stock (LEW/mai) are resistant to RVFV infections, whereas WF/mai rats are susceptible. Thus, inbred rat strains seem to differ in virus susceptibility depending on their breeding histories. A better genetic characterization of inbred rat strains and a revision in nomenclature is needed to improve animal experimentation in the future.

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2000-11-01
2024-04-18
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References

  1. Anderson G. W. Jr 1988; Viral and host determinants of resistance to Rift Valley fever in a rat model. PhD thesis The Johns Hopkins University; Baltimore, MD, USA:
  2. Anderson G. W. Jr, Smith J. F. 1987; Immunoelectron microscopy of Rift Valley fever viral morphogenesis in primary rat hepatocytes. Virology 161:91–100
    [Google Scholar]
  3. Anderson G. W. Jr, Peters C. J. 1988; Viral determinants of virulence to Rift Valley fever (RVF) in rats. Microbial Pathogenesis 5:241–250
    [Google Scholar]
  4. Anderson G. W. Jr, Slone T. W. Jr, Peters C. J. 1987; Pathogenesis of Rift Valley fever virus (RVFV) in inbred rats. Microbial Pathogenesis 2:283–293
    [Google Scholar]
  5. Benda P., Lightbody J., Sato G., Levine L., Sweet W. 1968; Differentiated rat glial cell strain in tissue culture. Science 161:370–371
    [Google Scholar]
  6. Bender K., Balogh P., Bertrand M. F., den Bieman M., von Deimling O., Eghtessadi S., Gutman G. A., Hedrich H. J., Hunt S. V., Kluge R., Matsumoto K., Moralejo D. H., Nagel M., Portal A., Prokop C.-M., Seibert R. T., van Zutphen L. F. M. 1994; Genetic characterization of inbred strains of the rat ( Rattus norvegicus. Journal of Experimental Animal Science 36:151–165
    [Google Scholar]
  7. Bouloy M., Janzen C., Vialat P., Huerre M., Pavlovic J., Haller O. 1999; High virulence of attenuated Rift Valley fever virus strains in mice lacking a functional type I interferon system [Abstract]. Journal of Interferon and Cytokine Research 19:Suppl. 1S75
    [Google Scholar]
  8. Caplen H., Peters C. J., Bishop D. H. L. 1985; Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development. Journal of General Virology 66:2271–2277
    [Google Scholar]
  9. Daubney R., Hudson J. R. 1931; Enzootic hepatitis or Rift Valley fever: an undescribed virus disease of sheep, cattle, and man from East Africa. Journal of Pathology 34:545–557
    [Google Scholar]
  10. Frese M., Kochs G., Feldmann H., Hertkorn C., Haller O. 1996; Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. Journal of Virology 70:915–923
    [Google Scholar]
  11. Gonzalez-Scarano F., Nathanson N. 1996; Bunyaviridae. In Fields Virology pp 1473–1504 Edited by Fields B. N., Knipe D. N., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  12. Laughlin L. W., Meegan J. M., Strausbaugh L. H., Morens D. M., Watten R. H. 1979; Epidemic Rift Valley fever in Egypt: observations of the spectrum of human illness. Transactions of the Royal Society of Tropical Medicine and Hygiene 73:630–633
    [Google Scholar]
  13. McCarthy K. D., de Vellis J. 1978; Alpha-adrenergic receptor modulation of beta-adrenergic adenosine and prostaglandin E1 increased adenosine 3′: 5′-cyclic monophosphate levels in primary cultures of glia. Journal of Cyclic Nucleotide Research 4:15–26
    [Google Scholar]
  14. McGavran M., Easterday B. C. 1963; Rift Valley fever virus hepatitis. American Journal of Pathology 42:587–607
    [Google Scholar]
  15. Meegan J. M. 1979; The Rift Valley fever epizootic in Egypt 1977–1978. 1. Description of the epizootic and virological studies. Transactions of the Royal Society of Tropical Medicine and Hygiene 73:618–623
    [Google Scholar]
  16. Peters C. J., Anderson G. W.Jr(1981; Pathogenesis of Rift Valley fever. Contributions to Epidemiology and Biostatistics 3:21–41
    [Google Scholar]
  17. Peters C. J., Linthicum K. J. 1994; In Handbook of Zoonoses, section B., Viral. , 2nd edn. pp 125–138 Edited by Beran G. W., Steele J. H. Boca Raton, FL: CRC Press;
  18. Peters C. J., Slone T. W. 1982; Inbred rat strains mimic the desperate human response to Rift Valley fever virus infection. Journal of Medical Virology 10:45–54
    [Google Scholar]
  19. Rosebrock J. A., Peters C. J. 1982; Cellular resistance to Rift Valley fever virus (RVFV) infection in cultured macrophages and fibroblasts from genetically resistant and susceptible rats. In Vitro 18:308
    [Google Scholar]
  20. Rosebrock J. A., Schellekens H., Peters C. J. 1983; The effects of ageing in vitro and interferon on the resistance of rat macrophages to Rift Valley fever virus. Anatomical Record 205:A165–A166
    [Google Scholar]
  21. Schmider W., Fahr A., Voges R., Gerok W., Kurz G. 1996; Irreversible inhibition of hepatic fatty acid salt uptake by photoaffinity labelling with 11,11-azistearate. Journal of Lipid Research 37:739–753
    [Google Scholar]
  22. Schramm U., Fricker G., Buscher H.-P., Gerok W., Kurz G. 1993; Fluorescent derivatives of bile salts. III. Uptake of 7β-NBD–NCT into isolated hepatocytes by the transport system for cholyltaurine. Journal of Lipid Research 34:741–757
    [Google Scholar]
  23. Siam A., Meegan J. M., Gharbawi K. F. 1980; Rift Valley fever ocular manifestations: observations during the 1977 epidemic in Egypt. British Journal of Ophthalmology 64:366–374
    [Google Scholar]
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