1887

Abstract

The homologous genes and were identified by differential display PCR as virus-induced genes in rainbow trout and humans, respectively. These genes are significantly related to sequences required for the biosynthesis of metal cofactors, but their function remains unknown. In this study, it is shown that the mouse homologue of / was induced by vesicular stomatitis virus (VSV) and pseudorabies virus (PrV) in mouse spleen cells. Among a collection of cell lines from dendritic, myeloid, lymphoid or fibroblast lineages, only the dendritic cell line, D2SC1, showed expression of after virus infection. This dendritic restriction was confirmed by our finding that was also induced by both VSV and PrV in CD11c spleen cells, separated by magnetic purification or derived from bone marrow precursor cells. Similar to the fish rhabdovirus viral haemorrhagic septicaemia virus in trout cells, VSV directly induced in the dendritic cell line D2SC1, but the PrV-mediated induction required the integrity of the interferon pathway. This result indicates that is interferon-inducible like its fish and human homologues. Furthermore, was also induced by LPS in bone marrow-derived cells. Thus, expression seems to correlate with an activated state of dendritic cells subjected to different pathogen-associated stimuli.

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2000-11-01
2019-10-21
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