@article{mbs:/content/journal/jgv/10.1099/0022-1317-81-11-2617, author = "Zimmermann, Holger and Koh, Choon-Heng and Degenkolbe, Roland and O’Connor, Mark J. and Müller, Andreas and Steger, Gertrud and Chen, Jason J. and Lui, Yun and Androphy, Elliot and Bernard, Hans-Ulrich", title = "Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53", journal= "Journal of General Virology", year = "2000", volume = "81", number = "11", pages = "2617-2623", doi = "https://doi.org/10.1099/0022-1317-81-11-2617", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-81-11-2617", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6–CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300.", }