1887

Abstract

High doses (>1·56×10 p.f.u.) of purified preparations of human adenovirus types 3, 5 and 8 exhibited definite pyrogenic activity when injected intravenously into rabbits. Complete pyrogenic tolerance was obtained not only with homologous types but also with heterologous types of adenovirus. No pyrogenic cross-tolerance was observed between each of these three adenovirus types and paramyxovirus pyrogen or bacterial lipopolysaccharide. Adenovirus pyrogenicity was retained after UV-inactivation, whereas it was inactivated by heating at 56 °C for 30 min. Adenovirus pyrogenicity was not neutralized by mixing with homologous type-specific antiserum but non-pyrogenic doses (10 p.f.u.) of adenovirus types 3, 5 and 8 became highly pyrogenic in the presence of type-specific antibodies at the optimal virus:antibody ratio. This enhanced pyrogenicity depended upon the virus–antibody complex. From these results, it is probable that the pyrogenic activity of the virus–antibody complex, rather than the pyrogenic activity of the virions, is the main contributor to fever in adenovirus infection under actual physiological conditions.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-81-11-2611
2000-11-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/81/11/0812611a.html?itemId=/content/journal/jgv/10.1099/0022-1317-81-11-2611&mimeType=html&fmt=ahah

References

  1. Akira S., Kishimoto T. 1992; IL-6 and NF-IL6 in acute-phase response and viral infection. Immunological Reviews 127:25–50
    [Google Scholar]
  2. Alcami A., Smith G. L. 1996; A mechanism for the inhibition of fever by a virus. Proceedings of the National Academy of Sciences, USA 93:11029–11034
    [Google Scholar]
  3. Alluwaimi A. M., Smith H., Sweet C. 1994; Role of surface glycoproteins in influenza virus pyrogenicity. Journal of General Virology 75:2835–2840
    [Google Scholar]
  4. Atkins E. 1960; Pathogenesis of fever. Physiological Reviews 40:580–646
    [Google Scholar]
  5. Bennett I. L. Jr, Wagner R. R., Lequire V. S. 1949; Pyrogenicity of influenza virus in rabbits. Proceedings of the Society for Experimental Biology and Medicine 71:132–133
    [Google Scholar]
  6. Bruder J. T., Kovesdi I. 1997; Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. Journal of Virology 71:398–404
    [Google Scholar]
  7. Coates D. M., Sweet C., Smith H. 1986; Severity of fever in influenza: differential pyrogenicity in ferrets exhibited by H1N1 and H3N2 strains of differing virulence. Journal of General Virology 67:419–425
    [Google Scholar]
  8. Crystal R. G., McElvaney N. G., Rosenfeld M. A., Chu C. S., Mastrangeli A., Hay J. G., Brody S. L., Jaffe H. A., Eissa N. T., Danel C. 1994; Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genetics 8:42–51
    [Google Scholar]
  9. Davatelis G., Wolpe S. D., Sherry B., Dayer J. M., Chicheportiche R., Cerami A. 1989; Macrophage inflammatory protein 1: a prostaglandin-independent endogenous pyrogen. Science 243:1066–1068
    [Google Scholar]
  10. Dinarello C. A. 1992; Role of interleukin-1 in infectious diseases. Immunological Reviews 127:119–146
    [Google Scholar]
  11. Dinarello C. A., Bernheim H. A., Duff G. W., Le H. V., Nagabhushan T. L., Hamilton N. C., Coceani F. 1984; Mechanisms of fever induced by recombinant human interferon. Journal of Clinical Investigation 74:906–913
    [Google Scholar]
  12. Dinarello C. A., Cannon J. G., Mancilla J., Bishai I., Lees J., Coceani F. 1991; Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Research 562:199–206
    [Google Scholar]
  13. Fastier L. 1952; Toxic manifestations in rabbits and mice associated with the virus of Western equine encephalomyelitis. Journal of Immunology 68:531–541
    [Google Scholar]
  14. Ginsberg H. S., Lundholm-Beauchamp U., Horswood R. L., Pernis B., Wold W. S., Chanock R. M., Prince G. A. 1989; Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proceedings of the National Academy of Sciences, USA 86:3823–3827
    [Google Scholar]
  15. Ginsberg H. S., Moldawer L. L., Sehgal P. B., Redington M., Kilian P. L., Chanock R. M., Prince G. A. 1991; A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proceedings of the National Academy of Sciences USA: 88:1651–1655
    [Google Scholar]
  16. Grossgebauer K. 1967; Virusbedingtes Fieber (Ergebnisse und Probleme). Klinische Wochenschrift 45:749–755
    [Google Scholar]
  17. Grossgebauer K. 1972; Zur Entstehung des Krankheitsfiebers beim vakziniavirusinfizierten Kaninchen. Archiv für die gesamte Virusforschung 38:357–365
    [Google Scholar]
  18. Horwitz M. S. 1996; Adenoviruses. In Fields Virology pp 2149–2171 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  19. Kato N. 1967; Nonhemagglutinating complement-fixing V antigen of parainfluenza 1 virus (HVJ). I. The production of nonhemagglutinating V antigen in chick embryos infected with HVJ. Virology 31:29–36
    [Google Scholar]
  20. Kato N., Hara H. 1961; The toxic effect on rabbits of influenza virus given intravenously. British Journal of Experimental Pathology 42:145–152
    [Google Scholar]
  21. Kato N., Matsumoto T., Maeno K., Okada A. 1961; A new strain of the hemagglutinating virus of Japan isolated from mice. Biken Journal 4:59–62
    [Google Scholar]
  22. Kato N., Okada A., Ota F. 1965; A factor capable of enhancing virus replication appearing in parainfluenza virus type 1 (HVJ)-infected allantoic fluid. Virology 26:630–637
    [Google Scholar]
  23. Kato N., Nakashima I., Ohta M. 1976; Adjuvant action of capsular polysaccharide of Klebsiella pneumoniae on antibody response. V. Further biological properties of the active substance. Japanese Journal of Microbiology 20:173–181
    [Google Scholar]
  24. King M. K. 1962; Production of fever in rabbits with extracts of tissue culture cells infected with Coxsackie virus. Journal of Laboratory and Clinical Medicine 59:986–992
    [Google Scholar]
  25. King M. K. 1964; Pathogenesis of fever in rabbits following intravenous injection of Coxsackie virus. Journal of Laboratory and Clinical Medicine 63:23–29
    [Google Scholar]
  26. Norrby E. 1969; The relationship between the soluble antigens and the virion of adenovirus type 3. IV. Immunological complexity of soluble components. Virology 37:565–576
    [Google Scholar]
  27. Pickering J. M., Smith H., Sweet C. 1992; Influenza virus pyrogenicity: central role of structural orientation of virion components and involvement of viral lipid and glycoproteins. Journal of General Virology 73:1345–1354
    [Google Scholar]
  28. Russell W. C., Valentine R. C., Pereira H. G. 1967; The effect of heat on the anatomy of the adenovirus. Journal of General Virology 1:509–522
    [Google Scholar]
  29. Shenk T. 1996; Adenoviridae : the viruses and their replication. In Fields Virology pp 2111–2148 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  30. Siegert R. 1967; Natur und Wirkungsmechanismus der Viruspyrogene. Deutsche Medizinische Wochenschrift 92:2183–2186
    [Google Scholar]
  31. Tokumaru T. 1967; The effect of trauma on production of herpes interferon in guinea pigs. Archiv für die gesamte Virusforschung 21:61–70
    [Google Scholar]
  32. Tokumaru T. 1968; Nature of febrile response to intravenous injection of large amounts of herpes simplex virus in guinea pigs. Archiv für die gesamte Virusforschung 23:257–269
    [Google Scholar]
  33. Valentine R. C., Pereira H. G. 1965; Antigens and structure of the adenovirus. Journal of Molecular Biology 13:13–20
    [Google Scholar]
  34. Vassalli P. 1992; The pathophysiology of tumor necrosis factors. Annual Review of Immunology 10:411–452
    [Google Scholar]
  35. Westphal O., Jann K. 1965; Bacterial lipopolysaccharides – extraction with phenol water and further application of the procedure. In Methods in Carbohydrate Chemistry pp 83–91 Edited by Whistler R. L. New York: Academic Press;
    [Google Scholar]
  36. Wilmott R. W., Amin R. S., Perez C. R., Wert S. E., Keller G., Boivin G. P., Hirsch R., De Inocencio J., Lu P., Reising S. F., Yei S., Whitsett J. A., Trapnell B. C. 1996; Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates. Human Gene Therapy 7:301–318
    [Google Scholar]
  37. Zampronio A. R., Souza G. E. P., Silva C. A. A., Cunha F. Q., Ferreira S. H. 1994; Interleukin-8 induces fever by a prostaglandin-independent mechanism. American Journal of Physiology 266:R1670–R1674
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-81-11-2611
Loading
/content/journal/jgv/10.1099/0022-1317-81-11-2611
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error