RT Journal Article SR Electronic(1) A1 Miralles, Rosario A1 Moya, Andrés A1 Elena, Santiago F. YR 1999 T1 Effect of population patchiness and migration rates on the adaptation and divergence of vesicular stomatitis virus quasispecies populations JF Journal of General Virology, VO 80 IS 8 SP 2051 OP 2059 DO https://doi.org/10.1099/0022-1317-80-8-2051 PB Microbiology Society, SN 1465-2099, AB The effect of migration among different isolated virus quasispecies populations on their adaptation and diversity was analysed through experimental evolution. An in vitro cell system was employed to simulate migration of vesicular stomatitis virus between isolated homogeneous host cell populations. The results clearly demonstrated a positive correlation between the migration rate and the magnitude of the mean fitness reached by the virus quasispecies populations. The results also showed, although less clearly, that fitness differences among quasispecies decreased with the magnitude of migration. These results are in close agreement with predictions of standard population genetics theory. These results can be explained in terms of the spread of beneficial mutations, originating in a single isolated quasispecies, through the entire system formed by the different quasispecies populations contained in different host cell populations., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-80-8-2051