1887

Abstract

Simian immunodeficiency virus (SIV) uses the CCR5 chemokine receptor as the main co-receptor to enter CD4+ cells. RANTES, MIP-1alpha and MIP-1beta have been suggested as the major human immunodeficiency virus-suppressor factors produced by CD8+ T-cells. The aim of this study was to investigate the CD8+ T-cell production of anti-viral factors and of beta-chemokines in six cynomolgus macaques vaccinated with live attenuated SIVmacC8 in relation to protection against infectious intrarectal SIVsm challenge. Three of the vaccinated animals were completely protected and one was partially protected against the challenge virus. Interestingly, these monkeys showed higher in vitro anti-viral CD8+ cell suppressor activity and beta-chemokine production both before and after vaccination as compared to the infected monkeys. The results indicate that beta-chemokines may play a role in protective immunity but also that genetic and/or environmental factors may influence their production.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-80-7-1569
1999-07-01
2022-12-06
Loading full text...

Full text loading...

/deliver/fulltext/jgv/80/7/0801569a.html?itemId=/content/journal/jgv/10.1099/0022-1317-80-7-1569&mimeType=html&fmt=ahah

References

  1. Abimiku A. G., Robert-Guroff M., Benson J., Tartaglia J., Paoletti E., Gallo R. C., Markham P. D., Franchini G. 1997; Long-term survival of SIVmac251 infected macaques previously immunized with NYVAC-SIV vaccines. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1:S78–S85
    [Google Scholar]
  2. Alkhatib G., Combadiere C., Broder C. C., Feng Y., Kennedy P. E., Murphy P. M., Berger E. A. 1996; CC CKR-5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955–1958
    [Google Scholar]
  3. Alkhatib G., Liao F., Berger E. A., Farber J. M., Peden K. W. C. 1997; A new SIV co-receptor, STRL33. Nature 388:238
    [Google Scholar]
  4. Andersson S., Mäkitalo B., Thorstensson R., Franchini G., Tartaglia J., Limbach K., Paoletti E., Putkonen P., Biberfeld G. 1996; Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys. Journal of Infectious Diseases 174:977–985
    [Google Scholar]
  5. Baier M., Werner A., Bannert N., Metzner K., Kurth R. 1995; HIV suppression by interleukin-16. Nature 378:563
    [Google Scholar]
  6. Blackbourn D. J., Locher C. P., Ramachandran B., Barnett S. W., Murthy K. K., Carey K. D., Brasky K. M., Levy J. A. 1997; CD8+ cells from HIV-2 infected baboons control HIV replication. AIDS 11:737–746
    [Google Scholar]
  7. Chen Z., Zhou P., Ho D. D., Landau N. R., Marx P. A. 1997; Genetically divergent strains of simian immunodeficiency viruses use CCR5 as a coreceptor for entry. Journal of Virology 71:2705–2714
    [Google Scholar]
  8. Choe H., Farzan M., Sun Y., Sullivan N., Rollins B., Ponath P. D., Wu L., Mackay C. R., LaRosa G., Newman W., Gerard N., Gerard C., Sodroski J. 1996; The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135–1148
    [Google Scholar]
  9. Cocchi F., DeVico A. L., Garzino-Demo A., Araya S. K., Gallo R. C., Lusso P. 1995; Identification of RANTES, MIP-1α and MIP-1β as the major HIV-suppressive factors produced by CD8+ cells. Science 270:1811–1815
    [Google Scholar]
  10. Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R. E., Hill C. M., Davis C. B., Peiper S. C., Schall T. J., Littman D. R., Landau N. R. 1996; Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661–666
    [Google Scholar]
  11. Deng H., Unutmaz D., KewalRamani V. N., Littman D. R. 1997; Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296–300
    [Google Scholar]
  12. Doranz B. J., Rucker J., Yi Y., Smyth R. J., Samson M., Peiper S. C., Parmentier M., Collman R. G., Doms R. W. 1996; A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors. Cell 85:1149–1158
    [Google Scholar]
  13. Dragic T., Litwin V., Allaway G. P., Martin S. R., Huang Y., Nagashima K. A., Cayanan C., Maddon P. J., Koup R. A., Moore J. P., Paxton W. A. 1996; HIV-1 entry into CD4 + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667–673
    [Google Scholar]
  14. Ennen J., Findeklee H., Dittmar M. T., Norley S., Ernst M., Kurth R. 1994; CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine. Proceedings of the National Academy of Sciences, USA 91:7207–7211
    [Google Scholar]
  15. Feng Y., Broder C. C., Kennedy P. E., Berger E. A. 1996; HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 272:872–877
    [Google Scholar]
  16. Furci L., Scarlatti G., Burastero S., Tambussi G., Colognesi C., Quillent C., Longhi R., Loverro P., Borgonovo B., Gaffi D., Carrow E., Malnati M., Lusso P., Siccardi A. G., Lazzarin A., Beretta A. 1997; Antig en-driven C-C chemokine-mediated HIV-1 suppression by CD4 + T cells from exposed uninfected individuals expressing the wild-type CCR-5 allele. Journal of Experimental Medicine 186:455–460
    [Google Scholar]
  17. Gotch F. M., Koup R. A., Saffrit J. T. 1997; New observations on cellular immune responses to HIV and T-cell epitopes. AIDS 11:S99–S107
    [Google Scholar]
  18. Haigwood N. L., Zolla-Pazner S. 1998; Humoral immunity to HIV, SIV, and SHIV. AIDS 12: Suppl AS121–S132
    [Google Scholar]
  19. Heeney J. L., Teeuwsen V. J. P., Van Gils M., Bogers W. M. J. M., De Giuli Morghen C., Radaelli A., Barnett S., Morein B., Akerblom L., Wang Y., Lehner T., Davis D. 1998; β-Chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques. Proceedings of the National Academy of Sciences, USA 95:10803–10808
    [Google Scholar]
  20. Hill C. M., Deng H., Unutmaz D., KewalRamani V. N., Bastiani L., Gorny M. K., Zolla-Pazner S., Littman D. R. 1997; Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interaction with this chemokine receptor. Journal of Virology 71:6296–6304
    [Google Scholar]
  21. Kannagi M., Chalifoux L. V., Lord C. I., Letvin N. L. 1988; Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes. Journal of Immunology 140:2237–2242
    [Google Scholar]
  22. Kinter A. L., Ostrowski M., Goletti D., Oliva A., Weissman D., Gantt K., Hardy E., Jackson R., Ehler L., Fauci A. S. 1996; HIV replication in CD4 + T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines. Proceedings of the National Academy of Sciences, USA 93:14076–14081
    [Google Scholar]
  23. Landay A. L., Mackewicz C. E., Levy J. A. 1993; An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clinical Immunology & Immunopatholgy 69:106–116
    [Google Scholar]
  24. Lehner T., Wang Y., Cranage M., Bergmeier L. A., Mitchell E., Tao L., Hall G., Dennis M., Cook N., Brookers R., Klavinskis L., Jones I., Doyle C., Ward R. 1996; Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Medicine 2:767–775
    [Google Scholar]
  25. Levy J. A., Mackewicz C. E., Barker E. 1996; Controlling HIV pathogenesis: the role of noncytotoxic anti-HIV response of CD8+ T cells. Immunology Today 17:217–224
    [Google Scholar]
  26. Liu R., Paxton W. A., Choe S., Ceradini D., Martin S. R., Horuk R., MacDonald M. E., Stuhlmann H., Koup R. A., Landau N. R. 1996; Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367–377
    [Google Scholar]
  27. Mackewicz C. E., Yang L. C., Lifson J. D., Levy J. A. 1994; Noncytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection. Lancet 344:1671–1673
    [Google Scholar]
  28. Mackewicz C. E., Blackborn D. J., Levy J. A. 1995; CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription. Proceedings of the National Academy of Sciences, USA 92:2308–2312
    [Google Scholar]
  29. Mackewicz C. E., Barker E., Greco G., Reyes-Teran G., Levy J. A. 1997; Do β-chemokines have clinical relevance in HIV infection?. Journal of Clinical Investigation 100:921–930
    [Google Scholar]
  30. Meyer L., Magierowska M., Hubert J. B., Rouzioux C., Deveau C., Sanson F., Debre P., Delfraissy J. F., Theodorou I. and the SEROCO study group 1997; Early protective effect of CCR-5 ∆32 heterozygosity on HIV-1 disease progression: relationship with viral load. AIDS 11:F73–F78
    [Google Scholar]
  31. Nilsson C., Thorstensson R., Gilljam G., Sjölander S., Hild K., Broliden K., Åkerblom L., Morein B., Biberfeld G., Putkonen P. 1995; Protection against monkey-cell grown cell-free HIV-2 challenge in macaques immunized with native HIV-2 envelope glycoprotein gp125. Vaccine Research 4:165–175
    [Google Scholar]
  32. Nilsson C., Mäkitalo B., Thorstensson R., Norley S., Binniger-Schinzel D., Cranage M., Rud E., Biberfeld G., Putkonen P. 1998; Live attenuated simian immunodeficiency virus (SIV)mac in macaques can induce protection against mucosal infection with SIVsm. AIDS 12:2261–2270
    [Google Scholar]
  33. Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J. L., Arenzana-Seisdedos F., Schwartz O., Heard J. M., Clark-Lewis I., Legler D. F., Loetscher M., Baggiolini M., Moser B. 1996; The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833–835
    [Google Scholar]
  34. Pal R., Garzino-Demo A., Markham P. D., Burns J., Brown M., Gallo R. C., DeVico A. L. 1997; Inhibition of HIV-1 infection by the β-chemokine MDC. Science 278:695–698
    [Google Scholar]
  35. Paliard X., Lee A. Y., Walker C. M. 1996; RANTES, MIP-1α and MIP-1β are not involved in the inhibition of HIV-1SF33 replication mediated by CD8+ T-cell clones. AIDS 10:1317–1321
    [Google Scholar]
  36. Putkonen P., Nilsson C., Walther L., Ghavamzadeh L., Hild K., Broliden K., Biberfeld G., Thorstensson R. 1994; Efficacy of inactivated whole vaccines with various adjuvants in cynomolgus monkeys. Journal of Medical Primatology 3:89–94
    [Google Scholar]
  37. Putkonen P., Mäkitalo B., Böttiger D., Biberfeld G., Thorstensson R. 1997; Protection of human immunodeficiency virus 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission. Journal of Virology 71:4981–4984
    [Google Scholar]
  38. Rosenberg E. S., Billingsley J. M., Caliendo A. M., Boswell S. L., Sax P. E., Kalams S. A., Walker B. D. 1997; Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278:1447–1450
    [Google Scholar]
  39. Rubbert A., Weissman D., Combadiere C., Pettrone K. A., Daucher J. A., Murphy P. A., Fauci A. S. 1997; Multifactorial nature of noncytolytic CD8 + T cell-mediated suppression of HIV replication: β-chemokine-dependent and -independent effects. AIDS Research and Human Retroviruses 13:63–69
    [Google Scholar]
  40. Samson M., Libert F., Doranz B. J., Rucker J., Liesnard C., Farber C. M., Saragosti S., Lapoumeroulie C., Cognaux J., Forceille C., Muyldermans G., Verhofstede C., Burtonboy G., Georges M., Imai T., Rana S., Yi Y., Smyth R. J., Collman R. G., Doms R. W., Vassart G., Parmentier M. 1996; Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722–725
    [Google Scholar]
  41. Shearer G. M., Clerici M. 1996; Protective immunity against HIV infection: has nature done the experiment for us?. Immunology Today 17:21–24
    [Google Scholar]
  42. Thorstensson R., Walther L., Putkonen P., Albert J., Biberfeld G. 1991; A capture enzyme immunoassay for detection of HIV-2/SIV antigen. Journal of Acquired Immune Deficiency Syndromes 4:374–379
    [Google Scholar]
  43. Walker C. M., Levy J. A. 1989; A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66:628–630
    [Google Scholar]
  44. Walker C. M., Moody D. J., Stites D. P., Levy J. A. 1989; CD8+ T lymphocyte control of HIV replication in cultured CD4 + cells varies among infected individuals. Cellular Immunology 119:470–475
    [Google Scholar]
  45. Walker C. M., Thomson-Honnebier G. A., Hsueh F. C., Erickson A. L., Pan L.-Z., Levy J. A. 1991; CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses. Cellular Immunology 137:420–428
    [Google Scholar]
  46. Zaitseva M., Blauvelt A., Lee S., Lapham C. K., Klaus-Kovtun V., Mostowski H., Manischewits J., Golding H. 1997; Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for primary HIV infection. Nature Medicine 3:1369–1375
    [Google Scholar]
  47. Zou W., Lackner A. A., Simson M., Durand-Gasselin I., Galanaud P., Desrosiers R. C., Emilie D. 1997; Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy. Journal of Virology 71:1227–1236
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-80-7-1569
Loading
/content/journal/jgv/10.1099/0022-1317-80-7-1569
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error