Brain injury does not modify transmissible spongiform encephalopathy caused by intraperitoneal inoculation with Fukuoka-1 strain Free

Abstract

The pathogenesis of neuroinvasion in Creutzfeldt-Jakob disease and other transmissible spongiform encephalopathies following the peripheral uptake of a disease agent is still not fully understood. The possibility of neuroinvasion either being established or being accelerated by an insult to the brain has not previously been tested. The experiment described herein was designed to examine this possibility by wounding the brain following an intraperitoneal challenge with a mouse-adapted strain of human transmissible spongiform encephalopathy, Fukuoka-1 strain. The results showed that brain injury introduced in any period before the appearance of cerebral abnormal prion protein deposition modified neither the clinical features, including the incubation period, nor the histopathology of the mice. Our findings suggest that neurovirulence of the agent may not be sufficiently promoted by brain injury.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-80-6-1551
1999-06-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/80/6/0801551a.html?itemId=/content/journal/jgv/10.1099/0022-1317-80-6-1551&mimeType=html&fmt=ahah

References

  1. Anon 1997; Creutzfeldt–Jakob disease associated with cadaveric dura mater grafts – Japan, January 1979–May 1996. Morbidity and Mortality Weekly Report 46:1066–1069
    [Google Scholar]
  2. Asher D. M., Gibbs C. J. Jr, Gajdusek D. C. 1976; Pathogenesis of subacute spongiform encephalopathies. Annals of Clinical Laboratory Science 6:84–103
    [Google Scholar]
  3. Beekes M., McBride P. A., Baldauf E. 1998; Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie. Journal of General Virology 79:601–607
    [Google Scholar]
  4. Brown P., Rohwer R. G., Dunstan B. C., MacAuley C., Gajdusek D. C., Drohan W. N. 1998; The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 38:810–816
    [Google Scholar]
  5. Casaccia P., Ladogana A., Xi Y. G., Pocchiari M. 1989; Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie. Archives of Virology 108:145–149
    [Google Scholar]
  6. Chung Y. L., Williams A., Beech J. S., Williams S. C., Bell J. D., Cox J., Hope J. 1995; MRI assessment of the blood-brain barrier in a hamster model of scrapie. Neurodegeneration 4:203–207
    [Google Scholar]
  7. Eklund C. M., Kennedy R. C., Hadlow W. J. 1967; Pathogenesis of scrapie virus infection in the mouse. Journal of Infectious Diseases 117:15–22
    [Google Scholar]
  8. Esmonde T. F., Will R. G., Slattery J. M., Knight R., Harries-Jones R., De Silva R., Matthews W. B. 1993; Creutzfeldt–Jakob disease and blood transfusion. Lancet 341:205–207
    [Google Scholar]
  9. Fraser H. 1976; The pathology of natural and experimental scrapie. In Slow Virus Diseases of Animals and Man pp 267–305 Edited by Kimberlin R. H. New York: North-Holland;
    [Google Scholar]
  10. Fraser H., Bruce M. E., Davies D., Farquhar C. F., McBride P. A. 1992; The lymphoreticular system in the pathogenesis of scrapie. In Prion Diseases of Humans and Animals pp 308–317 Edited by Collinge J., Powell J., Anderton B. Chichester: Ellis Horwood;
    [Google Scholar]
  11. Gajdusek D. C., Gibbs C. J. Jr, Collins G., Traub R. 1976; Survival of Creutzfeldt–Jakob disease virus in formalin-fixed tissue. New England Journal of Medicine 294:553
    [Google Scholar]
  12. Ghirnikar R. S., Lee Y. L., Eng L. F. 1998; Inflammation in traumatic brain injury: role of cytokines and chemokines. Neurochemical Research 23:329–340
    [Google Scholar]
  13. Gibbs C. J. Jr, Gajdusek D. C., Masters C. L. 1978; Considerations of transmissible subacute and chronic infections, with a summary of the clinical and virological characteristics of kuru, Creutzfeldt–Jakob disease and scrapie. In Senile Dementia A Biomedical Approach pp 115–130 Edited by Nandy K. New York: Elsevier/North-Holland Biomedical Press;
    [Google Scholar]
  14. Kimberlin R. H., Walker C. A. 1979; Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. Journal of Comparative Pathology 89:551–562
    [Google Scholar]
  15. Kimberlin R. H., Walker C. A. 1986; Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. Journal of General Virology 67:255–263
    [Google Scholar]
  16. Kimberlin R. H., Walker C. A. 1989; Pathogenesis of scrapie in mice after intragastric infection. Virus Research 12:213–220
    [Google Scholar]
  17. Kitamoto T., Muramoto T., Hilbich C., Beyreuther K., Tateishi J. 1991a; N-terminal sequence of prion protein is also integrated into kuru plaques in patients with Gerstmann–Sträussler syndrome. Brain Research 545:319–321
    [Google Scholar]
  18. Kitamoto T., Muramoto T., Mohri S., Doh-ura K., Tateishi J. 1991b; Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt–Jakob disease. Journal of Virology 65:6292–6295
    [Google Scholar]
  19. Kitamoto T., Shin R. W., Doh-ura K., Tomokane N., Miyazono M., Muramoto T., Tateishi J. 1992; Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt–Jakob disease. American Journal of Pathology 140:1285–1294
    [Google Scholar]
  20. Klein M. A., Frigg R., Flechsig E., Raeber A. J., Kalinke U., Bluethmann H., Bootz F., Suter M., Zinkernagel R. M., Aguzzi A. 1997; A crucial role for B cells in neuroinvasive scrapie. Nature 390:687–690
    [Google Scholar]
  21. Kuroda Y., Gibbs C. J. Jr, Amyx H. L., Gajdusek D. C. 1983; Creutzfeldt–Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. Infection and Immunity 41:154–161
    [Google Scholar]
  22. Lasmézas C.-I., Deslys J.-P., Demaimay R., Adjou K. T., Hauw J. J., Dormont D. 1996; Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy. Journal of General Virology 77:1601–1609
    [Google Scholar]
  23. Lynch W. P., Robertson S. J., Portis J. L. 1995; Induction of focal spongiform neurodegeneration in developmentally resistant mice by implantation of murine retrovirus-infected microglia. Journal of Virology 69:1408–1419
    [Google Scholar]
  24. Menache D., O’Malley J. P. 1996; Creutzfeldt–Jakob: current US policy to further reduce the possible risk of transmission by transfusion. Biologicals 24:277–283
    [Google Scholar]
  25. Morganti-Kossman M. C., Lenzlinger P. M., Hans V., Stahel P., Csuka E., Ammann E., Stocker R., Trentz O., Kossmann T. 1997; Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Molecular Psychiatry 2:133–136
    [Google Scholar]
  26. Prusiner S. B. 1991; Molecular biology of prion diseases. Science 252:1515–1522
    [Google Scholar]
  27. Ricketts M. N., Cashman N. R., Stratton E. E., Eisaadany S. 1997; Is Creutzfeldt–Jakob disease transmitted in blood?. Emerging Infectious Diseases 3:155–163
    [Google Scholar]
  28. Satoh J., Kurohara K., Yukitake M., Kuroda Y. 1998; Constitutive and cytokine-inducible expression of prion protein gene in human neural cell lines. Journal of Neuropathology and Experimental Neurology 57:131–139
    [Google Scholar]
  29. Schmitt T. L., Steiner E., Klinger P., Sztankay A., Grubeck-Loebenstein B. 1996; The production of an amyloidogenic metabolite of the Alzheimer amyloid beta precursor protein (APP) in thyroid cells is stimulated by interleukin 1 beta, but inhibited by interferon gamma. Journal of Clinical Endocrinology and Metabolism 81:1666–1669
    [Google Scholar]
  30. Tateishi J., Ohta M., Koga M., Sato Y., Kuroiwa Y. 1980a; Transmission of chronic spongiform encephalopathy with kuru plaques and leukomalacia to small rodents. Annals of Neurology 5:581–584
    [Google Scholar]
  31. Tateishi J., Sato Y., Koga M., Doi H., Ohta M. 1980b; Experimental transmission of human subacute spongiform encephalopathy to small rodents. I. Clinical and histological observations. Acta Neuropathologica 51:127–134
    [Google Scholar]
  32. Vorbrodt A. W., Dobrogowska D. H., Tarnawski M., Meeker H. C., Carp R. I. 1997; Immunocytochemical evaluation of blood-brain barrier to endogenous albumin in scrapie-infected mice. Acta Neuropathologica 93:341–348
    [Google Scholar]
  33. Williams A., Van Dam A. M., Ritchie D., Eikelenboom P., Fraser H. 1997; Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations. Brain Research 754:171–180
    [Google Scholar]
  34. Wisniewski H. M., Lossinsky A. S., Moretz R. C., Vorbrodt A. W., Lassmann H., Carp R. I. 1983; Increased blood–brain barrier permeability in scrapie-infected mice. Journal of Neuropathology and Experimental Neurology 42:615–626
    [Google Scholar]
  35. Wyss-Coray T., Masliah E., Mallory M., McConlogu L., Johnson-Wood K., Lin C., Mucke L. 1997; Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer′s disease. Nature 389:603–606
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-80-6-1551
Loading
/content/journal/jgv/10.1099/0022-1317-80-6-1551
Loading

Data & Media loading...

Most cited Most Cited RSS feed