RT Journal Article SR Electronic(1) A1 Tranulis, M. A. A1 Osland, A. A1 Bratberg, B. A1 Ulvund, M. J.YR 1999 T1 Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway. JF Journal of General Virology, VO 80 IS 4 SP 1073 OP 1077 DO https://doi.org/10.1099/0022-1317-80-4-1073 PB Microbiology Society, SN 1465-2099, AB Two-hundred and forty healthy sheep and 32 cases of natural scrapie in Norway were analysed for disease-linked polymorphisms in the prion protein (PrP) gene. Scrapie was strongly associated with the presence of a valine polymorphism at codon 136 (V136), as 68.8% of the cases were homozygous (VV136) and 15.6% were valine/alanine heterozygous (VA136). All cases were homozygous arginine/arginine at codon 154 (RR154), except two which were homozygous histidine/histidine (HH154). All cases except two were homozygous glutamine/glutamine at codon 171 (QQ171), the two exceptions being heterozygous glutamine/arginine (QR171). More than 80% of all scrapie cases in Norway have occurred in a Cheviot-related crossbred type of sheep called Rygja. This type of sheep, which is largely restricted to the south-western coast, carries the V136 allele at a higher frequency than do other breeds of Norwegian sheep. Polymorphisms at codons 138 and 151 are also described., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-80-4-1073