1887

Abstract

TT virus (TTV) is a newly identified single-stranded DNA virus. We retrospectively analysed serum samples from sixteen patients, infected with both hepatitis C virus (HCV) and TTV, and who had been treated with interferon. An elevated serum alanine aminotransferase level after interferon was associated with persistence of HCV (abnormal in five of seven patients with persistence of HCV compared with normal in all nine patients who showed eradication of HCV) irrespective of persistence of TTV. Comparison of partial viral DNA nucleotide sequences and phylogenetic analysis showed that viral strains that had a high identity to the prototype virus were more resistant to interferon than those showing low nucleotide sequence identity. Although we observed no liver cell injury caused by persistent TTV infection, the mechanism(s) of TTV resistance to interferon should be further investigated for a better understanding of viral diseases and establishment of therapy.

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/content/journal/jgv/10.1099/0022-1317-80-3-631
1999-03-01
2022-05-19
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References

  1. Chayama K., Saitoh S., Arase Y., Ikeda K., Matsumoto T., Sakai Y., Kobayashi M., Unakami M., Morinaga T., Kumada H. 1991; Effect of interferon administration on serum hepatitis C virus RNA in patients with chronic hepatitis C. Hepatology 3:1040–1043
    [Google Scholar]
  2. Chayama K., Tsubota A., Arase Y., Saitoh S., Ikeda K., Sakai Y., Matsumoto T. 1993; Quantitative analysis of hepatitis C virus RNA by competitive nested polymerase chain reaction. Journal of Gastroenterology and Hepatology 8:S40–44
    [Google Scholar]
  3. Davis G., Balart L., Schiff E. R., Lindsay K., Bodenheimer H. C. Jr, Perrillo R. P., Carey W., Jacobson I. M., Payna J., Dienstag J. L. 1989; Treatment of chronic hepatitis C with recombinant interferon alfa. New England Journal of Medicine 321:1501–1506
    [Google Scholar]
  4. Di Bisceglie A. M., Martin P., Kassianides C., Lisker-Melman M., Murray L., Waggoner J., Goodman Z., Banks S. M., Hoofnagle J. H. 1989; Recombinant interferon alfa therapy for chronic hepatitis C. New England Journal of Medicine 321:1506–1511
    [Google Scholar]
  5. Gojobori T., Ishii K., Nei M. 1982; Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. Journal of Molecular Biology and Evolution 18:414–423
    [Google Scholar]
  6. Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., Mayumi M. 1997; A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochemical and Biophysical Research Communications 241:92–97
    [Google Scholar]
  7. Okamoto H., Nishizawa T., Kato N., Ukita M., Ikeda H., Iizuka H., Miyakawa Y., Mayumi M. 1998; Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatology Research 10:1–16
    [Google Scholar]
  8. Saitou N., Nei M. 1987; The neighbor-joining method: a new method for reconstructing phylogenetic trees. Journal of Molecular Biology and Evolution 27:189–204
    [Google Scholar]
  9. Tanaka T., Tsukiyama-Kohara K., Yamaguchi K., Yagi S., Tanaka S., Hasegawa A., Ohta Y., Hattori N., Kohara M. 1994; Significance of specific antibody assay for of hepatitis C virus. Hepatology 19:1347–1353
    [Google Scholar]
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